PubMed Health⌕ Search

Biomedical subjects

F Nobili

Publications and source records attributed to F Nobili.

106 records · Page 6Linked to original sources
PubMed1982

Urodynamic in the diagnosis and treatment of urinary stress incontinence.

The authors examine the role of the urodynamic test on patients suffering from stress incontinence. The simultaneous recording of the flowmetry and of bladder and urethral pressures continues to be the most efficient method for the functional demonstration of urinary incontinence. According to the authors, however, it is necessary to evaluate, before the operation, the suitability of the bladder for surgical intervention to avoid any voiding disorders which might occur following surgery. The cystosphinctermanometry with simultaneous flowmetry, together with the stop test, allows for a precise analysis of the particular voiding habit of each bladder, thus permitting an evaluation of the two essential parameters for surgical treatment; bladder capacity, and the characteristics of the detrusor contractability.

Humans↗
PubMed1977

Application of nonparametric procedure for bioassay data to the evaluation of analgesics in man.

Parametric tests for bioassay data are commonly applied to scores of pain intensity and relief for the assessment of potency ratios of analgesic drugs. It has been demonstrated, however, that scores derived from semiquantitative scales often deviate from normal distribution. In addition, when scores decrease as a consequence of analgesic treatment, the variances may be nonhomogenous. Both parametric and nonparametric procedures have been employed in this study for the evaluation of results of a double-blind multicenter trial of the analgesic effect of indoprofen and ASA (both drugs at three dose levels) and placebo in episiotomy pain. There was a good agreement between potency ratios obtained with the two assays. Peak PID appeared a less efficient means of estimating potency ratio than other measurements such as SPID and TOTPAR. The nonparametric test for quantitative bioassay appears to be a valid statistical procedure for evaluating results of clinical trials, and it does not imply any assumptions as to the type of distribution of the data.

Adolescent↗
PubMedDate not supplied

Quantitative electroencephalography and regional cerebral blood flow: discriminant analysis between Alzheimer's patients and healthy controls.

Forty-two patients with probable Alzheimer's disease (AD) and 18 elderly healthy controls underwent quantitative EEG (qEEG) and regional cerebral blood flow (rCBF; 133Xe clearance) examinations. Correlations were sought between relative qEEG band powers and percent rCBF values in a posterior temporoparietal region of interest in either hemisphere. Moreover, stepwise discriminant analysis was applied to study the accuracy of the two techniques in differentiating AD from healthy ageing. rCBF and qEEG were correlated with one another, especially in the right hemisphere (p values ranging from <0.001 to <0.01). Significant correlations were found between Mini Mental State Examination (MMSE) and relative power of both the 2- to 6-Hz and the 6.5- to 12-Hz bands on either side (p < 0.001), and between MMSE and left rCBF (p < 0.005), while the correlation with right rCBF was poorer (p < 0.02). The statistical procedure identified the right values of both examinations for the discriminant analysis. Sensitivity of qEEG and rCBF employed together was 88% and specificity 89%, with a total accuracy of 88.3%. The unrecognized patients (n = 5) were affected by mild AD (4 scoring 3 at the Global Deterioration Scale and 1 scoring 4). qEEG alone showed an accuracy of 77% in the whole group and of 69% in mild AD, and rCBF alone an accuracy of 75% in the whole group and of 71% in mild AD. It is concluded that qEEG and rCBF examinations employed together are accurate tools to differentiate AD from normal ageing, although a lower degree of accuracy is achieved in mildly demented patients.

Aged↗
PubMedDate not supplied

Regional cerebral blood flow and prognostic evaluation in Alzheimer's disease.

The present investigation reports the application of regional cerebral blood flow (rCBF; (133)Xe method) to prognostic purposes in a consecutive series of 76 patients (mean age 68.4 +/- 8.7 years) with probable Alzheimer's disease (AD; NINCDS-ADRDA criteria). The likelihood that rCBF from a posterior temporal-inferior parietal area in each hemisphere at the first visit may predict timing of achievement of three endpoints (i.e. loss of activity of daily living, ADL, incontinence and death due to end-stage AD) was tested by the 'lifereg' procedure of the Statistical Analysis System package. With respect to baseline evaluation, 32 patients lost ADL 20.6 +/- 17.4 months later, 31 developed incontinence 27.1 +/- 19.0 months later, and 16 patients died after 40.9 +/- 23.8 months of follow-up. Baseline rCBF significantly predicted all end-points: the loss of ADL (left hemisphere: p = 0.04; right hemisphere: p = 0.02), incontinence (p = 0.02 in both hemispheres) and death (p = 0.01 in both hemispheres). Statistical significance was maintained for the loss of ADL and incontinence both in a subgroup of mildly demented patients, in whom death was not considered due to the low number of patients who died, and in a multivariate analysis including patient age, age at onset, sex, duration of illness, Mini-Mental State Examination score and presence of extrapyramidal signs and psychotic symptoms at the first visit. This study shows that rCBF measurement in a posterior temporal-inferior parietal area may give prognostic information on timing of evolution of AD, whenever performed during the course of the disease, and may be utilized both in clinical practice and for social planning.

Activities of Daily Living↗
PubMedDate not supplied

Phosphatidylserine: quantitative EEG effects in healthy volunteers.

Eight healthy paid male volunteers (age: 21-28 years, mean: 24.5 +/- 1.7 years; weight 62-79 kg) were administered via intravenous infusion (3 min) acute 25-, 50-, and 75-mg doses of phosphatidylserine, or matching placebo in a latin-square design. Multichannel EEG recordings were performed in baseline conditions, during intravenous infusion, and 10, 30, 90, 180, and 360 min after drug/placebo administration. Blood pressure, heart rate, critical flicker-fusion frequency, and the subjects' performance at immediate and short-term retention tests were assessed after each electroencephalographic (EEG) recording. The EEG signal was quantified off-line by power spectral analysis, and bidimensional scalp maps were produced for each EEG variable. Descriptive statistical comparisons among subjects and between pre- and postdrug EEG recordings allowed the detection of systematic EEG changes (notably increment of the power on the 'alpha' frequency, which was restricted to the anterior electrode deviations at the 50-mg dose and the widespread to the whole scalp at the highest dose, and increase of the signal total power) in the absence of significant modifications of the subjects' neuropsychological status.

Adult↗
PubMedDate not supplied

Regional cerebral blood flow in essential hypertension: data evaluation by a mapping system.

Regional cerebral blood flow was studied by means of the 133Xe inhalation method in 26 untreated and 10 treated patients with essential hypertension. The untreated subjects were divided into newly and previously diagnosed groups to assess the relation between regional cerebral blood flow and the duration of hypertension. The overall flow reduction was more marked in the frontal and temporal regions in the previously diagnosed group, and this was attributed to pathological changes in the district served by the middle cerebral artery. Regional temporal lobe impairment was also noted in the newly diagnosed and treated subjects. A significant correlation was found between regional cerebral blood flow and mean arterial blood pressure.

Aged↗
PubMedDate not supplied

[Regional cerebral blood flow and anxiety: a correlative study].

The effect of anxiety (measured by the state-trait anxiety inventory) on resting regional cerebral blood flow (rCBF) (measured by the 133-Xenon inhalation method) was studied in 38 female and 37 male patients undergoing rCBF examination for the first time. Significant negative correlations were found between anxiety and rCBF. This could contribute in understanding rCBF variability in the so-called "resting condition".

Adult↗
PubMedDate not supplied

[Antiendomysial antibodies: current role in the diagnosis of celiac disease compared to antigliadin antibodies].

We evaluated in parallel the action of antigliadin (AGA-IgA) and anti-endomysium (EmA) antibodies in a group of 144 coeliac patients during the various diagnostic procedures, and in 277 controls (206 affected by other gastroenterological diseases and 71 healthy or affected by non-gastroenterological diseases, not causing any immune changes). Little difference was observed between the two tests both during the initial phase of the disease and during gluten-free diet. No EmA positivity was observed in controls; AGA-IgA resulted positive in 6.3% of gastroenterological controls and in 5.6% of non-gastroenterological controls. Finally, the sensitivity, specificity and predictability of the two tests were evaluated in a sample of 92 subjects undergoing intestinal biopsy. The results show that the tests have the same sensitivity, but only for EmA 100% specificity was found.

Adolescent↗