Biomedical subjects

F Nuccetelli

Publications and source records attributed to F Nuccetelli.

7 recordsLinked to original sources

PubMed1995

Effects of fluoxetine on aggressive behavior of adult inpatients with mental retardation and epilepsy.

Nineteen mentally retarded inpatients with epilepsy and a history of current or recent aggressive behavior were treated with 20 mg of fluoxetine daily. All were concurrently taking other psychotropic medications, including carbamazepine and neuroleptics. A standardized rating scale (MOAS) was used to assess the effects of fluoxetine on aggressive behavior. There were wide individual differences in drug response. In nine patients, fluoxetine treatment was associated with increased aggression, while drug withdrawal led to a decrease to below pretreatment levels. Two hypotheses concerning the apparent association between fluoxetine and increased aggression are discussed: 1) adverse effects secondary to either drug interaction or fluoxetine overmedication; and 2) a specific serotonergically mediated effect on the regulation of aggression. This study suggests that the clinician who treats mentally retarded patients with impulsive aggressive behavior should remain aware that fluoxetine may have diverse effects on aggression that vary over time and interindividually.

Adult↗

PubMed1989

[Lymphocyte subpopulations in multiple sclerosis (MS). A contribution].

The characterization of peripheral blood T-cell subpopulations in 29 multiple sclerosis (MS) patients is studied. A direct immunofluorescence assay was performed using monoclonal antibodies (OK series) directed to lymphocytes surface antigens. In transverse study, the patients suffering from progressive MS showed T4+ lymphocytes and T4+/T8+ ratio significantly high (p less than 0.05) compared to controls; furthermore T8+ lymphocyte values were low. T3+ lymphocytes were low (p less than 0.05) during the relapse in the MS remitting relapsing patients. A six month follow-up of the patients showed, during relapse, a reduction and, immediately after, a recovery of T3+ and T4+ lymphocyte values; T8+ lymphocytes didn't show remarkable fluctuations.

Adult↗

PubMed1989

[Lymphotropic retrovirus in multiple sclerosis].

Several viruses have been considered in the etiology of Multiple Sclerosis (MS), but definitive proof have not been given so far. Recently, Gallo and Koprowski (1985) pointed out the retroviruses. In our study serum anti-HTLV I and anti-HTLV III antibodies were determined in 31 MS patients. Anti-HTLV I antibodies were found in the serum of only three MS patients (9.6%); none of the patients had anti-HTLV III antibodies.

Blood Donors↗

PubMed1989

[The prognosis of multiple sclerosis: a contribution].

A number of clinical characteristics of multiple sclerosis that may influence prognosis quo ad valetudinem are considered; onset with optic neuritis and frequency of recurrence less than 0.5/annum in the first three years of disease seem to be associated with a slower degree of deterioration (measured by the progression index). The age of onset, sex and type of disease would not appear to influence the prognosis.

Adult↗

PubMed1987

[Subacute cerebellar degeneration in cystadenopapillary carcinoma of the ovaries].

A subacute cerebellar degeneration-like paraneoplastic syndrome is reported in a woman with cystoadenopapillar carcinoma involving both ovaries. This syndrome, characterized by remarkable cerebellar ataxia, is an exceptional disorder which pathogenesis is still unknown although there is a hypothesis of a viral infection and autoimmunitary unchaining.

Cerebellar Ataxia↗

PubMed1987

[Westphal-Strumpell disease. Description of a clinical case].

A case of hepatolenticular degeneration with the clinical pattern of Westphal-Strumpell disease is described. Diagnosis was based on clinical pattern, absence of hepatic impairment, typical biochemical abnormalities of copper metabolism and response (clinical and biochemical) to D-penicillamine.

Adult↗

PubMed1986

[Diagnosis of thyroid nodules].

The basic features of the most common endocrine pathology, the thyroid nodule are analysed. After a brief assessment of the incidence of the condition the problem of clinical and instrumental diagnosis is tackled with the aim of demonstrating the value and possibility of sub-clinical diagnosis of micronodules. The present work aims to identify the fastest, most efficient and cheapest diagnostic procedure.

Biopsy↗