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F Ondrias

Publications and source records attributed to F Ondrias.

15 recordsLinked to original sources
PubMed2006

[Intraductal papillary proliferation of brest. Actual review and clinicopathological corelation].

OBJECTIVE: Complex summary addressing current view of the intraductal papillary lesions of breast, especially focused on morphology, exact terminology and clinicopathological aspects of effective therapy. DESIGN: Review article. SETTING: Biopsy Lab s.r.o. and Sikl's Department of Pathology, Charles University and Faculty Hospital, Pilsen. METHODS: Summarized recent data, diagnostic principals and clinicopathological recommendations of papillary breast lesions created comprehensive guide for daily diagnostic and therapeutic practice. RESULTS: The group of papillary tumors of the breast includes various lesions with different biologic potential. They are all presenting as pure intraductal lesions, but in case of multiple peripheral distribution imply possible risk for aggressive behavior. The reason is frequent occurrence of atypical ductal hyperplasia/intraductal (in situ) carcinoma in the adjacent tissue. Spectrum of secondary changes further complicates the diagnosis of papillary tumors, especially in core needle biopsy. Atypical papilloma is still very controversial issue and it essentially means situation when atypical ductal hyperplasia/conventional ductal in situ carcinoma arises in preexisting papillomas or extends to it from neighborhood. Generally, papillary lesions are suitable for effective conservative treatment in the case of proper clear resection margin. Finding of benign papilloma in core biopsy remains unsolved question yet.

Breast Neoplasms↗
PubMed2005

[Giant retroperitoneal liposarcomas].

According to literature liposarcomas account to less than 0.1% of all human tumors, 13% of which are localiced retroperitoneally. Authors describe two cases of giant retroperitoneal liposarcoms treated in their department. CT findings and the course of the disease discussed. Conlusively authors remark of high probability of microscopical residual disease with need of patients' follow up with eventual reoperation and adjuvant radiotherapy.

Aged↗
PubMed1995

[Pathologic findings in the uterine cervix--diagnostic aspects].

The study presents results of routine bioptic diagnoses. 651 lesions of cervix uteri have been diagnosed during a five-year period. The presented number represented a summary of 26% of the absolute number of 2513 registered neoplastic and precancerous lesions of the female genital. The group of patients yielded dominance of precancerous lesions of exo and endocervix, namely in 445 cases, i.e. 68%. Malign tumours of exo and endocervix uteri constituted a group of 185 cases, i.e. 28%. The study proves the world's trends of the development of pathological changes in cervix uteri where HPV infection represents one of the most significant factors. The two-year lasting evaluation of 27,093 cytologically examined patients revealed HPV infection in 748 female patients, i.e. in 2.8%. Summarization of the findings detected on the basis of cytologic and bioptic examinations proved the histologic correlation of HPV infection in 124 patients out of 467 patients afflicted with dysplastic or malign lesion of exocervix. (Tab. 1, Fig. 3, Ref. 13.)

Adult↗
PubMed1994

[Retrorectal and presacral tumors].

The group of patients with retrorectal and presacral tumours is presented. Their clinical picture, CT examination, results of biopsy and surgery treatment are analysed. The authors present the recent procedures of diagnosis and therapy of tumors in this location.

Adult↗
PubMed1993

[Morphologic findings in models of acute experimental pancreatitis].

Morphological changes found in two models of acute experimental pancreatitis are presented. Acute pancreatitis was induced in rats by the method of ligation of the lateral pancreatic ducts and by the method of the blind duodenal loop. After four hours the animals were sacrificed and processed for light and electron microscopic examination. Changes indicative of edematous and necrotizing pancreatitis were recorded. In the electron microscopic picture the predominant findings were disintegration of organelles of acinar cells and the appearance of numerous vacuoles and autophagosomes. The presented models of pancreatitis are considered to be suitable for further research into the pathogenesis and therapeutic intervention of acute pancreatitis in rats. (Fig. 15, Ref. 8.)

Acute Disease↗
PubMed1992

[Pathology of the uterine cervix. Infectious lesions of the endocervix and exocervix].

Bioptic findings from the region of the endo- and exocervix of the uterus were analyzed in a retrospective study covering the years 1988-1990. The series studied consisted of 366 women. Infectious processes in the cervix were evaluated in this first part of the study. Over the period investigated, 155 cases of cervicitis were established. Of these 56 (36.2 %) were acute bacterial, 17 (10.9 %) were lympho-plasmocytic (chlamydial), and 4 (2.5 %) were herpetic. The largest group of 78 (50.3 %) patients had HPV induced lesions. Koilocytic dysplasia was grouped into three grades according to severity. Mild dysplasia occurred in 16 patients (22 %), intermediate in 19 patients (26 %) and severe dysplasia in 37 patients (52 %). (Fig. 6, Ref. 15.).

Acute Disease↗
PubMed1992

[Precancerous and malignant tumors of the uterine cervix].

Bioptic findings recorded in 366 women with lesions of the endocervix and exocervix were analyzed in a retrospective study covering the years 1988 to 1990. The series represented 24.5% of the total number of 1495 gynecological precancerous and tumorous changes. Severe dysplastic changes and malignant tumors of the endocervix were seen in 31 patients (19.4%). Concurrence of endocervical and exocervical lesions was recorded in 66 patients (18.0%). In the studied series 35% of the women were below the age of 40 years. Signs of koilocystic dysplasia were recorded in 72 women (37%) with precancerous and tumorous lesions. (Fig. 4, Ref. 15.)

Adult↗
PubMed1990

Mixed hepatoblastoma in the adult: morphological and immunohistochemical findings.

A case of mixed hepatoblastoma in a 66-year-old man is discussed. Assessment of malignant mesenchymal and malignant epithelial elements yields the diagnosis. In the reported case, the epithelial area consisted of fetal hepatocytes. Distinct ductal differentiation, chondroid and even asteoid metaplasia were recorded. The morphological and immunohistochemical findings observed in the given patient are compared with data published in the world literature.

Aged↗
PubMed1990

[Microscopic diagnosis of mixed and mesenchymal tumors of the mucosa and uterine body].

A series of 452 with 831 precancerous and tumorous lesions of the corpus uteri is presented. The series was obtained by analyzing the authors' own series of bioptic findings covering the period of two years. Some problems arising at the evaluation of proliferating myogenic and stromal precancerous and tumorous lesions are pointed out. "Classical" types of leiomyomas were found to be predominant, amounting to 78.5% of tumors recorded at the studied site. Of the total number of tumors of the corpus uteri, malignant tumors constituted only 8.5%. On evaluating the series of malignant tumors of the corpus uteri epithelial malignant tumors (94.3%) were overwhelmingly prevailing over sarcomatous tumors. Attention is called to problems of histological evaluation of prognosis of mesenchymal and mixed tumors. Literary data as well as the authors' own observations indicate the necessity of exact and particularly of differentiated histological evaluation of the described tumors.

Biopsy, Needle↗
PubMed1985

The etiology of underlying liver lesions in 70 autopsied cases of hepatocellular carcinoma.

In 70 patients with hepatocellular carcinoma without history of antineoplastic chemotherapeutic drugs, anabolic and contraceptive steroids, representative sections of nonneoplastic liver tissue were examined for the presence of etiological markers. Hepatitis B surface antigen-positive hepatocytes were found in 16 (22.8%), alpha-1-antitrypsin globules in 3 (4.2%), Mallory bodies in 9 (12.8%), acicular inclusions in 1 (1.4%), diffuse giant mitochondria in 2 (2.8%), copper-binding protein in 25 (35.7%), greater amount of hemosiderin in 9 (12.8%) cases. Thorotrast was not detected. One or more markers were seen in 38 (54.3%) cases, most frequently in association with liver cell dysplasia and alcoholism. The presence of hepatitis B surface antigen in livers with dysplastic foci was highly significant as compared to organs showing no dysplasia. Only the mentioned antigen and the alpha-1-antitrypsin globules were found to indicate the etiology of the underlying liver lesion. The value of the other markers was found inconsistent in etiological diagnosis.

Adolescent↗
PubMed1985

Malignant tumors and embolizing paraneoplastic endocarditis.

A group of 4495 autopsied patients was evaluated. In 1011 (22.5%) of them various malignancies were found. In 20 of these cancer patients (2%) also a nonbacterial verrucous endocarditis was observed. The most serious complication of this paraneoplastic syndrome was central arterial embolization resulting in cerebral and myocardial infarctions. In our group this was observed in 12 patients (60%), in 9 cases of them infarction was the immediate cause of death. Fatal complications due to central embolization were seen also in 3 patients who had a malignant disease without symptoms of generalization. The most frequent tumors observed among the autopsied patients were adenocarcinomas of the digestive tract (40%). In the group of revealed tumors adenocarcinomas clearly prevailed (70%) in 10 cases (50%) also mucin production could be detected.

Adenocarcinoma↗