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Biomedical subjects

F Orozco

Publications and source records attributed to F Orozco.

17 recordsLinked to original sources
PubMed2001

Cementless femoral fixation in the rheumatoid patient undergoing total hip arthroplasty: minimum 5-year results.

Sixty-two total hip arthroplasties in 49 patients with a diagnosis of rheumatoid arthritis were performed between November 1986 and December 1992. All components were titanium alloy with a circumferential plasma-spray porous coating. Four patients (4 hips) died before 5-year follow-up, and 6 patients (8 hips) were lost to follow-up, leaving 39 patients (50 hips) for review at a minimum 5-year follow-up after surgery (mean, 8 years; range, 5-12 years). There were 12 men and 27 women, with a mean age at time of surgery of 55 years (range, 25-77 years) and a mean weight of 69 kg (range, 42-109 kg). Compared with the preoperative Charnley scores, there was significant improvement in the postoperative scores: pain, from 2.7 to 5.7, and function, from 3.2 to 5.3. Thigh pain was present in 1 patient (1 hip) (2.0%). No femoral fractures occurred intraoperatively with the insertion of the prosthesis. Spot welds consistent with bone ingrowth were identified in all of the femoral components. No femoral components showed evidence of radiographic loosening or required revision for aseptic loosening or incapacitating thigh pain, but 7 acetabular revisions were performed. Uncemented femoral fixation with this component design in rheumatoid patients appears to be a promising treatment.

Adult↗
PubMed2001

Primary cementless total hip arthroplasty in octogenarians. Two to eleven-year follow-up.

BACKGROUND: Cementless total hip arthroplasty is an accepted alternative to total hip arthroplasty with cement in younger patients, but it remains controversial for elderly patients. The purpose of this study was to evaluate the clinical and radiographic outcomes of cementless total hip arthroplasty with use of a proximally coated stem in patients who were at least eighty years of age at the time of the operation. METHODS: One hundred and twenty-three cementless total hip replacements were performed for the treatment of osteoarthritis in 114 patients between the ages of eighty and eighty-nine years. Seven patients (eight hips) died within two years after the surgery, seventeen patients (eighteen hips) died more than two years postoperatively but were not followed for at least two years, and five hips were lost to follow-up; this left ninety-two hips in eighty-six patients for review. The mean duration of follow-up was five years (range, two to eleven years). For the clinical evaluation, the Charnley modification of the Merle d'Aubigné and Postel scale was used. In addition, preoperative and postoperative Harris hip scores were available for sixty-nine hips. Seventy-eight hips were followed radiographically for two years or more. The focus of the radiographic evaluation was the status of the fixation of the femoral and acetabular components as well as cup wear. RESULTS: Perioperative medical complications occurred in association with 24% (thirty) of the 123 operations, but there were no deaths. The mean Charnley scores for pain and function for the ninety-two hips that were followed clinically for at least two years improved by 3.0 and 1.4 points, respectively. The sixty-nine hips for which preoperative and postoperative Harris hip scores were available had a mean improvement of 42 points, with a mean score of 82 points at the last follow-up evaluation. Mild thigh pain was present in four patients, but it did not limit their activity. There were no femoral component revisions. All of the femoral components were radiographically stable and had bone ingrowth. No acetabular component failed by loosening, but 41% (thirty) of the seventy-three hips with radiographs available for measurement of wear showed polyethylene wear. Of the seventy-eight cups that were followed radiographically for two years or more, 4% (three) were associated with lysis, but none had been revised. CONCLUSIONS: Cementless fixation in the elderly is safe, effective, and durable at the time of two to eleven-year follow-up.

Aged↗
PubMed1992

[Single oral dose of phosphomycin trometamol versus pipemidic acid and norfloxacin in treating uncomplicated low-level urinary tract infections].

OBJECTIVE: To make an assessment of the effectiveness and safety of a single oral dose compared with the conventional way of treating low-level Urinary Infections presenting no complications. DESIGN: This was an investigative and prospective study, using a control, a simple blind and randomised sample. SITE. Health Centres in Oviedo and Zaragoza. PATIENTS OR OTHERS PARTICIPANTS: We looked at 150 patients and included 106 females between the ages of 16 and 75 in the study. Their clinical symptoms were compatible with low-level urinary infections presenting no complications. INTERVENTIONS: 49 patients were given Trometamol Phosphomicine (TP) in a single oral dose; 36 took Pipemidic Acid (PA) and 21 Norfloxacine (NFX), both of these in a dose of 400 mg twice a day for 5 to 7 days. MAIN MEASUREMENTS AND RESULTS: Clinical and bacteriological assessments of the results were made 3, 7, and 28 days after treatment. A total of 75 gems were isolated: E. coli was the most common (68%). In all three groups, the main symptoms rapidly disappeared after the start of the treatment. CONCLUSIONS: Having considered the bacteriological and clinical findings, as well as tolerance levels, we are able to conclude that a single oral dose of Trometamol Phosphomicine is a good alternative to conventional therapy for the treatment of low-level Urinary Infections Which present no complications.

Administration, Oral↗
PubMed1979

[Area mesencephalica on the raphe and its importance. (Stereometric reconstruction in cat) (author's trnsl)].

The cat's mesencephalic raphe, caudally extended to the locus ceruleus and rostrally to the habenulo-interpedunculary area, was reconstructed with foamy-plastic plates in a stereotaxis ensemble of the brainstem. This reconstruction serves as an important reference to the topography and for interpreting the functional background of the stereotaxic lesions accumulated in the last 5 years. The alterations of the lung's alveolar interstitium after the nervous lesions, were classified in different groups of common evolution.

Animals↗
PubMed1976

A dynamic study of genotype-environment interaction with egg laying of Tribolium castaneum.

Within-line family selection was carried out at an optimum (33 degrees C) and two stress temperatures (28 degrees C and 38 degrees C) for increasing egg number laid by virgin females of Tribolium castaneum from the 7th to the 11th day after adult emergence. A control was maintained throughout the experiment. Two replicated lines were selected at each temperature and all selected lines were tested in each of the three environments. Direct and correlated responses to selection in different environments have been analysed in order to study implications of genotype-environment interaction on the selection outcome. Although selection at the optimum environment has been the most effective it did not confer the specialisation needed for performance in stress environments. However, selecting in adverse environments led to a broader range of performance over environments, which in one case (38 degrees C) included the optimum one. The degree of adaptation to adverse environments was mainly determined by the magnitude of the genetic correlation between performances in the adverse and the optimum environments. The evolution of such correlations through selection has also been investigated.

Adaptation, Physiological↗
PubMedDate not supplied

A genetic study of the buff columbian color pattern in Prat chickens.

The genetic basis for plumage color in the Prat fowl, a spanish breed with columbian restricted pattern, was studied, and results of crosses between the Prat and a recessive wheaten tester line (ey/ey co+/co+) or the Castellana breed (E/E), showed that it carries a wheaten allele at the E locus. Crosses between the Prat and the Light Brown Leghorn (e+/e+ co+/co+) or the Brown (eb/eb co+/co+) tester lines showed that the wheaten allele is the dominant one (ewh). These crosses suggested that the brown allele (eb) is also present at low frequency. The dominant columbian restriction gene (Co) seems to be involved in the Prat breed, interacting with the dominant wheaten allele to produce the characteristic plumage of the breed. Results of crosses between the Prat and the Vasca, another Spanish breed with gold columbian restricted pattern and ewh/ewh Co/Co genotype showed that they both differ by one major gene affecting phaeomelanin intensity. The Prat breed is well characterized by the orange buff down and by the ginger red adult plumage.

Animals↗