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Biomedical subjects

F P Shabbo

Publications and source records attributed to F P Shabbo.

7 recordsLinked to original sources

Aspergillus prosthetic valve endocarditis.

A 66-year-old man developed Aspergillus fumigatus endocarditis, complicated by an aortic root abscess 9 months after his aortic valve replacement with a Carpentier Edwards xenograft. The aortic root was replaced with an antibiotic-treated fresh homograft and anti-fungal chemotherapy commenced 24 hours later. One month after this he developed a retrosternal pseudo-aneurysm of the ascending aorta. At re-operation the homograft was heavily infected with fungal growths and the patient was considered inoperable. This case is an example of a rare condition complicating cardiac valve prosthesis which still has a very poor prognosis, despite any surgical and chemotherapeutic efforts.

Aged↗

Antibiotic prophylaxis for cardiac surgery: current United Kingdom practice.

A questionnaire was sent to 120 United Kingdom cardiac surgeons to ask for information on their use of prophylactic antibiotics in adult cardiac surgical patients. Data on type and duration of antibiotic were specifically sought. The response rate was 91%. All respondents used prophylactic antibiotics: 32% used single agents (second and third generation cephalosporins were the most commonly used) and 68% used either two (89%) or three (11%) antibiotics in combination. The total duration of prophylactic antibiotic treatment was less than 48 hours for 89% of respondents. Single dose antibiotics were used by only 6%. The use of prophylactic antibiotics has changed in the past few years, with a trend away from combinations of antibiotics to single agents. The duration of use of antibiotics has shortened and the use of single dose agents has increased.

Anti-Bacterial Agents↗

Surgical treatment of false aneurysm of the left ventricle after myocardial infarction.

Rupture of the left ventricle after myocardial infarction results either in sudden death from cardiac tamponade or, when pericardial adhesions are present, in bleeding that is confined to a limited space, which gradually expands as the blood flows through a small communicating orifice under high pressure, forming a false aneurysm. In three such patients a false aneurysm of the left ventricle after myocardial infarction was successfully treated by operation. The interval from the initiating event to the time of surgery averaged 10 months. Two of the patients had pericarditis and all presented at some stage of the illness with tachyarrhythmias and cardiac failure. All the patients survived operation and have improved functionally. Because of the propensity of false aneurysms to rupture, early diagnosis and aggressive surgical treatment are recommended.

Female↗

Thermography in assessing coronary artery saphenous graft patency and blood flow.

Infrared thermography has been used in 32 patients undergoing coronary artery saphenous bypass graft surgery in our department, in order to visualise graft patency and flow at the time surgery. 16 of these patients also had flow measurements with the use of electromagnetic flow meters to one or more of their grafts, which had already been thermographed in order to establish a correlation between the two methods. This study has confirmed that grafts which show good flow by means of electromagnetic flow meters also have a good pictorial graft patency and flow with infrared thermography.

Coronary Artery Bypass↗

Right ventricular outflow reconstruction with aortic homograft conduit: analysis of the long-term results.

One hundred and four patients with complex congenital heart disease were operated between 1966 and 1978 for reconstruction of the right ventricular outflow using an aortic homograft conduit. The average age was 14 years, ranging between 3 years and 28 years of age with an equal male/female ratio. Hospital mortality was 50% and there were 3 late deaths (6%) amongst the surviving 52 patients. Seventy-nine percent of the survivors are well and asymptomatic between 1 year and 12 years follow-up. Only 2 patients (4%) developed homograft conduit obstruction with a peak systolic gradient over 40 mmHg and 1 patient needed reoperation 9 years after the original primary reconstruction. Thirty-one patients underwent cardiac catheterization between 1 year and 9 years following the original operation, and a further 9 patients underwent a second cardiac catheterization at a mean of 36 months after their first cardiac catheterization. Ninety-three percent of these 31 patients had a resting peak systolic gradient across the homograft conduit of between 0 and 55 mmHg (mean 14.16 +/- 14.03). Calcification in the wall of the aortic homograft appeared within the first 2 years in about 80% of the patients but this had no correlation to the gradient across the homograft, nor did it interfere with the valve performance.

Adolescent↗