High affinity interactions between blood serum albumin and five substances of various chemical structure, exhibiting distinct physiological activity, were accompanied by alterations in the protein tertiary structure, while the albumin secondary structure was involved in conformational transformation after less effective affinity binding.

Dinitrobenzenes↗

PubMedDate not supplied

[Program-objective method of planning in pharmacology].

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Organization and Administration↗

PubMedDate not supplied

[Penetration and binding strength of cadmium and its complexes with dithiols in cells].

It was shown in experiments with three types of cells (dog red cells, hepatic cells of newborn Wistar rats, and culture of the renal epithelium of Vero monkeys) that cadmium in complexes with dimercaptoethanol penetrates the cells in an 8-33-fold greater amounts than free cations of metal. Unithiol increases cadmium penetration in the cells by 1.6-3 times only. The strength of cadmium binding with dimercaptopropranolol in the cells is greater than that with unithiol and free cations. Albumin limits penetration of free cations of cadmium and of complexes with dimercaptothiol to a greater degree than that of cadmium complexes with unithiols. The reasons for the differences revealed are discussed.

Absorption↗

PubMedDate not supplied

[Thiol compounds in the combined therapy of prozerin poisonings].

The authors studied the protective action of dithiols (unithiol, dithiothreitol) and their combinations with atropine in proserine poisoning. With the use of the spatial-prospective plotting the antidote efficacy of dipyroxime, atropine, dithiothreitole, and their combinations was studied and compared. A new type of potentiation was discovered upon combined use of atropine, dipyroxime and dithiothreitol.

Animals↗

PubMedDate not supplied

[Mefenaminic acid binding by blood plasma and organ homogenates].

Concerns the spectrophotometric method for microdetermination of total and unbound mefenaminic acid in biological material. The method has been developed on the basis of stained complex formation. Mefenaminic acid binding to plasma proteins and organ homogenates has been studied in vitro and in vivo experiments and by the methods of equilibrium dialysis and fluorescence. The rate of drug binding to plasma proteins amounts to 75 +/- 5%. The highest binding capacity is shown by the plasma, liver and kidneys. In the plasma, mefenaminic acid is chiefly bound to albumin in whose molecule there have been established two monotypic sites of binding with an association constant of approximately (1.23-1.68) . 10(5) M-1. In vivo experiments show variations in the relative indices of plasma bound mefenaminic acid as dependent on the dose and route of administration. In vitro evidence correlates with the results obtained in experiments made in vivo.

Animals↗

PubMedDate not supplied

[Anticyan--a new highly effective antidote in cyanide poisoning].

Anticyan is a highly effective antidote of cyanic acid and cyanide-containing compounds. It was created at the Institute of Pharmacology and Toxicology of AMS of Ukraine. Anticyan differs from other existing cyanide antidotes in that it possesses a tready methemoglobin-formation activity, has no hypotensive effect and is capable of direct stimulation of cyanide-inhibited tissue respiration.

Antidotes↗

PubMedDate not supplied

[Amizon in the treatment of nervous system involvement in herpes zoster].

The authors submit results of treatment of patients having suffered from postherpetic pain syndrome (herpetic ganglionitis of the cervical, thoracic, lumbosacral localization, postherpetic intercostal neuralgia, ganglionitis of the trigeminal nerve). In viral diseases, amizone has marked analgetic, antiinflammatory, and immunomodulating effects. The drug is well tolerated by patients, is not associated with side effects under prescribed doses (0.25-0.75 as one dose on a three- or four-times daily schedule during the course of treatment lasting three or four weeks). The drug preparation in question is less effective in the treatment of chronic recurring post-therapeutic intercostal neuralgias, radiculalgia.

Adult↗