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Biomedical subjects

F Parisi

Publications and source records attributed to F Parisi.

51 records · Page 3Linked to original sources
PubMed1990

Cardiomyopathy and multicore myopathy with accumulation of intermediate filaments.

A girl affected by a restrictive cardiomyopathy with neuromuscular involvement is described. Morphological examination showed a pattern of multicore myopathy and with electron microscopy a sarcoplasmic accumulation of electron dense granular and filamentous material was demonstrated both in skeletal muscle and heart. This peculiar electron dense material corresponded to increased desmin in muscle and cardiac fibres and was demonstrated immunohistochemically.

Adolescent↗
PubMed1989

Late hemodynamic results after orthotopic heart transplantation in early infancy.

To study the late hemodynamic results after infant orthotopic heart transplantation, five late survivors, as of October 1988, underwent right and left cardiac catheterization and endomyocardial biopsy. Mean age at transplantation was 1.4 +/- 1.5 months. Mean post-transplantation period was 17 +/- 5.6 months. All patients were on maintenance immunotherapy. The systemic and mixed venous saturations were normal, with no intracardiac shunt. The atrial and pulmonary artery anastomoses were widely patent. Three patients had coarctation of the aorta with a respective gradient of 24, 26, and 30 mm Hg; two were successfully treated by balloon angioplasty. The right-side hemodynamics were normal in all patients. Left ventricular pressures were elevated only in the patients with coarctation. The ventricular ejection fraction was normal. The right ventricular endomyocardial biopsy revealed no evidence of rejection. The mean cardiac index was 4.7 liter/min/m2 (range, 3.68-5.9). These data indicate excellent hemodynamic results and support orthotopic heart transplantation as therapy for selected neonates and infants with incurable heart disease.

Angiocardiography↗
PubMed1989

Anesthetic management of neonatal cardiac transplantation.

Anesthetic management of thirteen neonatal heart transplant patients is reviewed. Donor management, preoperative, operative and early postoperative management is discussed. Ten of 13 patients in this series survived the operation and appear to be developing normally.

Anesthesia, General↗
PubMed1987

Palliative Mustard operation: an expanded horizon.

From March 1982 to December 1983, five patients with a mean age 7 years (4 months-16 years) underwent a palliative Mustard operation for complex cardiac anomalies. The diagnoses were: univentricular heart with pulmonary vascular obstructive disease (PVOD) (2 cases); criss-cross heart with intact atrial septum, ventricular septal defect (VSD), transposition of the great arteries (TGA) and moderate pulmonary stenosis; isolated atrioventricular discordance with VSD; TGA, diminutive right ventricle and multiple VSDs. Cardiac catheterization showed unfavourable direction of flow: the oxygen saturation in the aorta was lower than in pulmonary artery, with a mean difference of 13.5% (range 6% to 30%). In no case was anatomical or physiological repair considered advisable because of the unfavourable intracardiac anatomy or the presence of PVOD. In two patients the atrial rerouting was accompanied by pulmonary artery banding. There were no hospital or late deaths in a mean follow-up of 36 months (range 29 to 50 months). The mean post-operative arterial oxygen saturation was 95.4% (range 92% to 99%).

Adolescent↗
PubMed1986

Simultaneous patency of ductus arteriosus and surgical shunt in pulmonary atresia with intact ventricular septum. A cause of acute myocardial failure?

Twenty-seven patients with pulmonary atresia and intact interventricular septum were treated with prostaglandin E1 infusion, followed by standard or modified Blalock-Taussig shunt. Three infants died. In all three there was anatomic and functional patency of the ductus arteriosus and the surgical systemic-pulmonary shunt. The unusual clinical course in these cases suggests that in the clinical management of patients with pulmonary atresia and intact interventricular septum after a shunt operation, particular attention must be paid to the problems associated with persistent ductal patency.

Ductus Arteriosus, Patent↗
PubMed1983

Colonic electromyography in chronic constipation.

Myoelectric activity of the sigmoid has been studied in 12 patients with chronic nonorganic constipation and 10 control subjects. All patients showed total gastrointestinal transit time longer than 96 h, with left-colonic or rectocolonic slowed transit. Electrical and mechanical activity was recorded by means of an intraluminal probe with bipolar suction electrodes and open-ended tips. Two groups of frequencies of slow waves, a slower rhythm at approximately 3 cycles/min and a faster rhythm at approximately 6 cycles/min were recorded in patients and control subjects. The mean frequency of the slower rhythm was significantly (p less than 0.005) higher in patients with constipation than in control subjects, whereas the frequency of the faster rhythm and the incidence of both rhythms were similar in the two groups. Mechanical activity showed no difference in terms of motility index and percentage of activity between patients and control subjects. Results of the study indicate that patients with left colonic constipation show an increase in frequency of the slower colonic rhythm in the very segment in which slowing down of transit occurs. It is suggested that the higher slow-wave activity in the sigmoid induces an increase in segmenting contractions and therefore may be responsible for the slowing down of intestinal transit.

Chronic Disease↗
PubMed1975

Maternal serum heat-stable alkaline phosphatase. In normal and high-risk pregnancies.

To evaluate its specificity as an indicator of placental function or fetal status, maternal serum heat-stable alkaline phosphatase (HSAP) was measured serially in 76 normal and 161 high-risk pregnancies (1272 determinations). The previously reported curvilinear HSAP rise starting at about 28 gestational weeks was noted. No relation was seen between HSAP levels and milk or moderate hypertension, gestational diabetes, nontoxemic placental insufficiency, or maternal blood group. HSAP levels were mostly above normal in proteinuric hypertension and were low normal in pregnant insulin-dependent diabetics. Two neonatal deaths were associated with normal HSAP levels. Of 4 intrauterine deaths, 1 was associated with high, 1 with low, and 2 with rising values in the normal range. Serial maternal HSAP values are apparently not a specific indicator of placental function or fetal status.

Adult↗
PubMedDate not supplied

Peripheral blood stem cells in children with solid tumors. Part II. Immunocytologic detection of tumor cells in bone marrow and peripheral blood stem cell harvests.

Simultaneous comparative assessment of tumor contamination in bone marrow aspirates and peripheral blood stem cell collections using immunocytochemical techniques was done in 6 children with neuroectodermal tumors. In 3 neuroblastoma patients tumor cells were detected in 5 of 16 marrow samples but not in peripheral blood stem cells. Clonogenic tumor cell reinfusion in the autologous support setting may be avoided in neuroblastoma patients by using peripheral blood stem cells.

Adolescent↗