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Biomedical subjects

F Patel

Publications and source records attributed to F Patel.

49 records · Page 3Linked to original sources
PubMed1991

Radiation-induced proctosigmoiditis. Prospective, randomized, double-blind controlled trial of oral sulfasalazine plus rectal steroids versus rectal sucralfate.

In a prospective study, 37 consecutive patients with radiation-induced proctosigmoiditis were randomized to receive a four-week course of either 3.0 g oral sulfasalazine plus 20 mg twice daily rectal prednisolone enemas (group I, N = 18) or 2.0 g twice daily rectal sucralfate enemas plus oral placebo (group II, N = 19). The two groups were comparable with respect to demographic features, duration of symptoms, and clinical and endoscopic staging of the disease. Fifteen patients in group I and 17 in group II completed the trial. At four weeks, both groups showed significant clinical improvement (P less than 0.01 for group I and P less than 0.001 for group II) and endoscopic healing (P less than 0.01 for group I and P less than 0.001 for group II). When the two groups were compared, sucralfate enemas showed a significantly better response as assessed clinically (P less than 0.05), although endoscopically the response was not statistically different (P greater than 0.05). We conclude that both treatment regimens are effective in the management of radiation proctitis. Sucralfate enemas give a better clinical response, are tolerated better, and because of the lower cost should be the preferred mode of short-term treatment.

Administration, Oral↗
PubMed1990

Sucralfate enema in ulcerative rectosigmoid lesions.

To assess the efficacy of sucralfate enemas in distal colonic ulcerative lesions, 22 patients with radiation proctitis (n = 8), idiopathic ulcerative proctitis (n = 5), and solitary rectal ulcer (n = 5) unresponsive to conventional medical therapy, and those with ulcerated and bleeding rectal polyps awaiting polypectomy (n = 4) were studied. Enemas of sucralfate suspension (2 gm in 20 ml water) were administered twice daily for a period of three weeks. Clinical and sigmoidoscopic improvements were observed in 19 and 18 of the 22 patients, respectively (86 and 82 percent, respectively). No side effects were seen. The authors conclude that sucralfate enemas are useful in the treatment of ulcerative lesions of the rectosigmoid.

Administration, Topical↗
PubMedDate not supplied

Fetal mild hydronephrosis and chromosomal defects: relation to maternal age and gestation.

The presence of multiple ultrasonographic abnormalities is associated with a significantly increased risk of chromosomal defects, while for isolated abnormalities, the association is less clear. In a study of 1,177 fetuses with mild hydronephrosis at 16-26 weeks of gestation, the fetal karyotype was abnormal in 86 (7.3%) of the cases and the most common chromosomal defects were trisomies 21, 18 and 13. The frequency of chromosomal defects increased with the number of additional abnormalities and for each chromosomal defect there was a characteristic pattern of associated abnormalities. However, in the 805 fetuses with apparently isolated hydronephrosis there were 5 (0.62%) with trisomy 21. On the basis of the maternal age and gestational age distribution of the population the expected frequency of trisomy 21 was 0.40%, which was not significantly different from the observed (0.62%). To demonstrate that such a difference is significant, it would be necessary to investigate at least 1 million pregnancies. In the meantime, parents could be counselled that the presence of mild hydronephrosis does not increase significantly the risk that the fetus has trisomy 21. Alternatively, the risk is 1.6 times higher than the maternal age and gestational age-related risk.

Adolescent↗
PubMedDate not supplied

Comparison of chorion villus sampling and early amniocentesis for karyotyping in 1,492 singleton pregnancies.

This was a prospective study in 1,492 women with singleton viable pregnancies undergoing chorion villus sampling (CVS) or early amniocentesis (EA) at 10-13 weeks of gestation because of advanced maternal age, parental anxiety or family history of chromosomal abnormality in the absence of parental chromosomal rearrangement. They were offered the option of having CVS or EA, or to be randomised into one of the two tests. CVS was performed in 652 cases (375 by choice and 277 by randomisation) and EA was performed in 840 cases (562 by choice and 278 by randomisation). Both procedures were carried out by transabdominal ultrasound-guided insertion of a needle (20 gauge) using a free-hand technique. The two techniques were similar in providing a sample (CVS 99.3%, EA 100%) and in giving a non-mosaic cytogenetic result (CVS 97.5%, EA 97.9%). Spontaneous loss (intrauterine or neonatal death) after EA (total group 4.9%, randomised subgroup 5.8%) was significantly higher than after CVS (total group 2.1%, randomised subgroup 1.8%; difference 2.8%, 95% CI 1.3-4.3%, and difference 4%, 95% CI 1.3-6.7%). The gestation at delivery and birth weight of the infants after EA and CVS were similar. In the EA group the incidence of talipes equinovarus (1.66%) was higher than in the CVS group (0.48%), but this difference was not significant.

Adult↗
PubMedDate not supplied

Hands off: coroner's case.

The public has to be educated in the peculiarities of medical jurisprudence. Mass disasters play into the hands of the press. A sensationalized media interest may exacerbate grief to the bereaved families and detract from informed disclosure of a legitimate coronial investigation.

Autopsy↗