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Biomedical subjects

F Paul

Publications and source records attributed to F Paul.

At least 55 records · Page 3Linked to original sources
PubMed1985

The morphology and viability of blood components processed by high-gradient magnetic separation.

The effect of high-gradient magnetic separation on blood components has been investigated. For erythrocytes there is no significant change in the morphology, size distribution and in the in-vivo survival times at the confidence level P = 0.05. For neutrophils stimulated nitro-blue tetrazolium reduction is maintained after HGMS. No change in chemotaxis and yeast cell phagocytosis was observed. Platelet distribution curves show no detectable changes before and after filtration. It is concluded that blood separated by HGMS is suitable for diagnostic analysis and may be considered for return to the patient.

Animals↗
PubMed1985

Famotidine versus ranitidine for the short-term treatment of duodenal ulcer.

One-hundred and eight-three patients with endoscopically proven duodenal ulcers, enrolled in this prospective, double-blind study, were randomly allocated to receive famotidine 40 mg once at night, 20 mg twice daily, 40 mg twice daily, or ranitidine 150 mg twice daily for 2-8 weeks. Pretreatment characteristics between the four groups were similar. After 4 weeks of treatment, among the famotidine-treated patients, 38 of 42 (90.5%) healed with the 40 mg once nightly regimen, 35 of 42 (83.3%) with 20 mg twice daily, and 37 of 41 (90.2%) with 40 mg twice daily. In the ranitidine group 40 of 43 patients (93.0%) healed. After 8 weeks of treatment, the respective data were: 97.6, 95.2, 100 and 93.0%. Different results between the famotidine groups and the ranitidine group were not statistically significant. All treatments were well tolerated and severe adverse events were rare. Famotidine 40 mg given once at night appears to be as safe and effective as conventional therapy with ranitidine, indicating the importance of overnight gastric acidity in the pathogenesis of duodenal ulcer disease.

Adolescent↗
PubMed1985

[Famotidine versus ranitidine in the acute treatment of duodenal ulcer. A multicenter comparative study in Germany].

185 patients with endoscopically proven duodenal ulcers were randomly allocated to treatment with either famotidine 40 mg nocte, 20 mg bid, 40 mg bid or ranitidine 150 mg bid for 2-8 weeks in a prospective double-blind study. The four groups were similar with regard to age, sex, duration of ulcer disease, smoking habits etc. After 2 weeks treatment 28/42 patients (66.7%) healed on famotidine 40 mg nocte, 24/42 patients (57.1%) on famotidine 20 mg bid, 26/41 patients (63.4%) on famotidine 40 mg bid and 28/43 patients (65,1%) on ranitidine 150 mg bid. The corresponding healing rates after 4 weeks were 90.5%, 83.3%, 90.2% and 93%, respectively. After 8 weeks more than 93% of the patients had healed ulcers. At each time there was no statistical difference between the different famotidine regimens and the ranitidine group. All treatments were well tolerated and severe adverse events were rare. Famotidine 40 mg at night, therefore, appears to be as good as conventional ranitidine.

Adolescent↗
PubMed1984

A simple magnetic method for the purification of malarial pigment.

Using a simple magnetic separation apparatus, Plasmodium berghei malarial pigment has been purified 200-fold in a single step. The technique exploits the paramagnetic properties of malarial pigment (hemozoin) and provides a simple and rapid method for the isolation of this material with high purification and yield.

Animals↗
PubMed1983

[Immunohistologic determination of a tumor marker (CEA) in diseases of the gastrointestinal tract].

CEA levels in serum are not reliable markers of tumors. In this paper a method for determination of this antigen for tissue sections is given. Histology, immunohistology and serum levels of CEA were compared. Tissue sections were obtained by surgical and endoscopic techniques. In several cases there was a discrepancy between serological and morphological results. Based on recent investigations elevated CEA levels might be only useful in reflecting a relapse of carcinoma of the colon. Immunohistological determinations were done by IFT and PAP-method. The results of both assay systems were comparable. CEA could be also detected in benign neoplasiogenic tissue, i.e. in tubular type of adenomatose polyps and in ulcerative colitis. Both diseases are known to become malignant at an high degree. By contrast no CEA could be detected in hyperplasiogenic polyps. Detection of CEA in malignant tissue might be useful for final classification of tumors. Occurrence of CEA in non malignant tissue should give rise to control in short regular intervals. Prospective studies might show the reliability of the CEA-bearing cells of non malignant tissue.

Adolescent↗
PubMed1978

Differential blood cell separation using a high gradient magnetic field.

A technique for the separation of erythrocytes from whole blood is described which exploits the magnetic property of haemoglobin in the reduced state. The technique is characterized by the use of a filter consisting of a cylinder, containing stainless steel wire mesh, placed between the jaws of an electro magnet. When activated, the electromagnet induces a magnetic field gradient in the vicinity of each of the constituent wires, sufficient to attract and trap erythrocytes in suspension. The number of erythrocytes captured varies with the applied field (0-1.4 Tesla in these experiments) and flow rate (1.9-12.9 x 10(-4) m s-1). The capture process does not cause haemolysis or observable surface damage to the erythrocytes and neither leucocytes nor platelets are retained by the filter.

Cell Separation↗
PubMed1978

Response of basal and pentagastrin-stimulated gastric secretion and of serum gastrin to short- and long-term intravenous infusion of salmon calcitonin in hyperchlorhydric subjects.

In 23 volunteers with gastric hyperchlorhydria the effect of intravenous administration of salmon calcitonin (SMC) on basal (n = 11) and pentagastrin-stimulated gastric secretion (n = 12) and on immunoreactive serum gastrin (n = 11) was studied under various experimental conditions. SMC (0.075 microgram . kg(-1) . 2h(-1) and 0.3 microgram . kg(-1) . h(-1)) caused a statistically significant reduction of HCl output of 75% and 80% and of pepsin of 55% and 90%. Serum gastrin concentration showed a dose-dependent decrease of 17% and 31% respectively. Pentagastrin-stimulated acid secretion was moderately inhibited by short-term administration of SMC (0.15 and 0.30 microgram . kg(-1) . 30 min(-1)), the effect being confined to the period of application of the hormone. Long-term infusion of the smaller dose for 2 1/2 h induced a sustained decrease of HCl output by 55%. It is assumed that SMC inhibits gastric secretion mainly by interfering with the production or liberation, or both, of gastrin. Whether long-term administration of SMC has advantages over substances currently used as therapeutic inhibitors of gastric secretion, e.g. in gastroduodenal bleeding, has yet to be investigated.

Adult↗
PubMed1977

Oligoclonal gamma-globulin banding of cerebrospinal fluid in patients with subacute sclerosing panencephalitis. Comparison of the electrophoretic pattern with that in multiple sclerosis and congenital infections.

Lumbar cerebrospinal fluid (CSF) of 8 patients with subacute sclerosing panencephalitis (SSPE) was examined by agarose gel electrophoresis. In comparison with normal controls and children with different neurological diseases (including infections, tumours and degenerative diseases) the quantitative evaluation of the pherograms by an analog computer revealed an extreme change of the gamma-globulin profile. All cases showed 6-7 abnormal subfractions consisting of 2-4 tall, markedly protruding spikes and several small intermediate fractions. The oligoclonal gamma-globulin contributed 20.1-42.5% to total protein. This particular gamma-globulin profile seems to be highly indicative of the diagnosis of SSPE. It can be distinguished from the oligoclonal pattern in patients suffering from multiple sclerosis (MS) and congenital infections. The CSF protein profile of 13 patients with MS was different from that in SSPE in that it showed 1-5 monoclonal gamma-fractions in every case with none or only one peak protuding more markedly. The percentage of all subfractions amounted to 4.5-23.8% of total protein. As in MS, the aspect of oligoclonality in 9 children with congenital infections (cytomegalic inclusion body disease, toxoplasmosis and rubella) was quite variable, as again 1-5 abnormal subfractions were detected. Their relative concentrations, on the whole ranging from 0.6-12% of total protein, was considerably lower than in SSPE.

Adolescent↗