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Biomedical subjects

F Peters

Publications and source records attributed to F Peters.

At least 37 records · Page 2Linked to original sources
PubMed1985

Ovarian hyperstimulation due to long-term pulsatile intravenous GnRH treatment.

Pulsatile long-term gonadotropin releasing hormone (GnRH) therapy with an average dosage of 8 micrograms/pulse i.v. in intervals of 90 min induced in a patient with hypothalamic amenorrhea the development of multiple ovarian cysts as visualized by ultrasonography. Estradiol (E2) plasma concentration reached values of 5000 pg/ml. These findings indicate that pulsatile GnRH application can induce ovarian hyperstimulation.

Adult↗
PubMed1985

Serum prolactin levels in women with excessive milk production. Normalization by transitory prolactin inhibition.

Serum prolactin levels and milk yield were studied in 27 puerperae with excessive milk production (polygalactia) and compared with 30 normally lactating puerperae. In order to normalize polygalactia, 14 of these women were treated with 2.5 mg bromocriptine per day for 3 days starting on post-partum day 5, 13 women received placebo. Milk flow in polygalactic women started significantly earlier than in puerperae with normal milk yield and developed mean milk volumes of 816 g per day on post-partum day 4. Serum prolactin levels did not differ from levels of puerperae with normal milk yield. There was no correlation between serum prolactin and milk yield. Bromocriptine treatment resulted in a sharp but reversible decline of serum prolactin levels followed by a significant reduction of milk production. Bromocriptine could not be detected in milk specimens, while serum levels showed significant amounts. In placebo treated women prolactin levels and milk yield remained unaffected. These data indicate that serum prolactin concentrations of puerperae with polygalactia are within the normal post-partum range. Short term prolactin suppression by bromocriptine can reduce milk yield, without complete ablactation.

Bromocriptine↗
PubMed1979

Clinical electrophysiologic effects of encainide, a newly developed antiarrhythmic agent.

Encainide is a newly developed antiarrhythmic agent. With the use of intracardiac electrophysiologic techniques, its effects on the cardiac conduction system were examined in 10 patients with coronary artery disease. Five patients received 0.6 and five received 0.9 mg/kg body weight of encainide intravenously over 15 minutes. Plasma concentration, heart rate, blood pressure and conduction intervals (A-H, H-V, QRS and Q-T) were measured before, during and after encainide infusion. In addition, sinus nodal recovery time, Wenckebach cycle length, and atrial, atrioventricular (A-V) nodal and right ventricular refractory periods were measured before and after encainide infusion. The average peak plasma concentration was 0.49 +/- 0.35 microgram/ml (mean +/- standard error of the mean). Encainide significantly prologned H-V and QRS intervals in all patients by an average of 31 +/- 7 and 18 +/- 9 percent (standard deviation) (P less than 0.001), respectively. A minimal increase in the Q-T interval was also observed after encainide infusion (2 +/- 9 percent, P less than 0.01), but no significant changes were noted in heart rate, blood pressure, A-H interval, corrected sinus noal recovery time, Wenckebach cycle length or refractory periods of the atrium, A-V node or right ventricle. It is concluded that encainide significantly prolongs conduction in the His-Purkinje system without affecting conduction or refractoriness of other parts of the cardiac conduction system in man.

Aged↗
PubMed1979

DIADEM--a system for the interactive data acquisition and processing in an analytical laboratory.

A conversational program for the acquisition of experimental data in a multi-user, multi-instrument computer system is described. It assists the researcher when recording on-time data. Due to the simple structure of the dialogue, no special knowledge of computer handling is required by the experimenter. Whereas the experimental methods are versatile, a uniform concept of the dialogue and the file structure is realized.

Chemistry Techniques, Analytical↗
PubMed1979

Numerical analysis of binding studies: a direct procedure avoiding the pitfalls of a Scatchard analysis of equilibrium data for unknown binding models.

It is shown on theoretical grounds that the straightforward analysis of binding data according to Scatchard may lead to erroneous results, especially when more complicated binding schemes are involved. We have demonstrated this point by presenting Scatchard plots with slight variation of experimental parameters. These inherent difficulties of Scatchard analyses can be avoided by applying a direct procedure. We have developed a program, which compares the measured quantity and the theoretical value directly and which considers the following binding models: (i) independent equivalent binding of n ligands; (ii) independent unequivalent binding of 2 ligands; (iii) positive or negative cooperative binding of 2 ligands. Other binding schemes can easily be implemented. We have used this procedure for the evaluation of equilibrium data on the complex formation of tRNA-Tyr and tyrolyl tRNA synthetase from E. coli in terms of different binding models.

Amino Acyl-tRNA Synthetases↗
PubMed1979

Inhibition of prolactin and lactation by methylergometrine hydrogenmaleate.

Reports on the effect of methylergometrine hydrogenmaleate (MEM) on prolactin (PRL) secretion and lactation are still controversial. Therefore a prospective study was designed to follow the influence of MEM on post-partum PRL levels and milk production. MEM was given orally to 30 post-partum women from day 1 to day 7 in a daily dose of 0.6 mg. Thirty untreated women served as control. PRL plasma levels and milk yield were compared at day 1, 3 and 7. PRL levels were significantly lower in the treated group at day 7 (P less than 0.01), while the difference at day 3 was statistically not significant. Milk yield was significantly reduced at day 3 (P less than 0.05) and day 7 (P less than 0.01). These results indicate PRL inhibiting properties of MEM resulting consequently in reduced lactation.

Depression, Chemical↗
PubMed1978

[Secondary amenorrhoea (author's transl)].

27 patients with secondary amenorrhoea for 6--20 months were investigated with a gonadorelin (GnRH-)test and a psychoanalytical exploration. Results, which were determined independently of each other, were then correlated. According to the gonadorelin and the gestagen test patients could be allocated to four groups: test group 1 = negative gestagen test, LH peak below 8 ng/ml, test group 2 = positive gestagen test, LH peak below 8 ng/ml, test group 3 = positive gestagen test, LH peak 8--20 ng/ml, test group 4 = positive gestagen test, LH peak 20--37 ng/ml. According to the psychoanalytical exploration two groups of patients could be differentiated. Patients of test group 1 and 2 showed psychosomatic disorders to a greater extent with pronounced associated somatic symptoms and predominantly retentive personality structures. Patients in test groups 3 and 4 showed predominantly associated mental symptoms accompanied by better insight into their own conflicts.

Adult↗
PubMed1978

The hemodynamic effects of intravenous tocainide in patients with heart disease.

In order to evaluate its hemodynamic actions, tocainide, a new orally effective antiarrhythmic drug, was given intravenously over a 15 minute period to 12 patients with compensated left ventricular dysfunction. Doses were 0.5 (4 patients) or 0.75 (8 patients) mg/kg/min. Hemodynamics and drug plasma concentrations were measured at the end and 15 minutes after the end of the infusion. Tocainide infusion produced small but statistically significant increases in the pulmonary and systemic vascular resistance, aortic and pulmonary arterial pressure, and left and right ventricular end-diastolic pressure. There was no significant change in left ventricular dp/dt, heart rate, or cardiac index. In patients with compensated left ventricular dysfunction, tocainide produces a small rise in vascular resistance and arterial pressure. Overall cardiac function is maintained with a small increase in left ventricular end-diastolic pressure.

Adult↗
PubMed1978

Effect of pyridoxine on plasma levels of HGH, PRL, and TSH in normal women.

The effect of chronic administration of pyridoxine (vitamin B6) on HGH, basal and TRH stimulated PRL and TSH levels was studied in seven healthy female volunteers. HGH and TSH basal levels remained unaffected. Basal PRL and TRH stimulated PRL and TSH levels were slightly reduced without statistical significance (P greater than 0.05). The results indicate, that stimulation of the hypothalamic dopaminergic pathway by pyridoxine is highly variable and unpredictable. Therefore it seems meaningless to recommend vitamin B6 for the treatment of hyperprolactinaemia.

Administration, Oral↗
PubMed1978

[Nonpuerperal mastitis in the hormonal stimulated breast (author's transl)].

Three patients with nonpuerperal mastitis are presented. The inflammation was supposedly related to hormonal stimulation of the breast. One patient suffered from hyperplasia of the breast, the second patient exhibited a rapidly growing fibroadenoma, a third patient developed a recurrent purulent mastitis on the basis of galactorrhea. All patients improved after exclusive administration of bromocriptine without the addition of antibiotics.

Adenofibroma↗