PubMed Health⌕ Search

Biomedical subjects

F Peterson

Publications and source records attributed to F Peterson.

12 recordsLinked to original sources
PubMed1996

Transdermal estrogen replacement therapy: beneficial effects on hemostatic risk factors for cardiovascular disease.

OBJECTIVES: To assess the effect of estrogen replacement therapy on hemostatic risk factors for cardiovascular disease (CVD) in postmenopausal women during 2 years of treatment. METHODS: In an open prospective study, patients (n = 42) were investigated before and during 2 years of treatment, and compared to an untreated postmenopausal control group (n = 18) followed during the same period, healthy premenopausal women (n = 20) being included as a reference group for premenopausal values. The patients underwent treatment with transdermal 17 beta-estradiol (E2) (50 micrograms/24 h), oral medroxyprogesterone acetate (5 mg/day) being added for 12 days every second month. RESULTS: After 2 years of treatment there was a significant increase in t-PA antigen (P = 0.01) and a significant decrease in F VII antigen (P = 0.01). PAI-1 antigen concentrations decreased slightly. Fibrinogen concentrations were already significantly decreased at 3-month follow-up (P = 0.01), and were still low after 2 years. By contrast, at 2-year follow-up the postmenopausal control group manifested significant increases in F VII and PAI-1 antigen and slight increases in fibrinogen, which resulted in significant differences between patients and controls. Regression analysis showed the increase in the serum estradiol concentrations to be inversely correlated to the decreases in the plasma concentrations of F VII antigen (r = -0.34, P = 0.001) and fibrinogen (r = -0.35, P = 0.001). There were no changes in AT III or protein C in any group. CONCLUSIONS: The increase in serum estradiol concentrations due to replacement therapy did not adversely affect the studied components of the fibrinolytic and protein C defense system against thrombosis, and resulted in beneficial decreases in F VII antigen and fibrinogen. These findings may help to explain the beneficial effects of estrogen replacement therapy in terms of protection from cardiovascular disease.

Administration, Cutaneous↗
PubMed1988

Reliability of health knowledge measurement in very young children.

This study documented reliability of a picture identification instrument and determined its utility with young children in selected preschool programs. Three hundred eleven children, ages three-five, were selected from formal early childhood education programs in three states. A comprehensive health knowledge instrument, consisting of 30 items, was administered to all children, and a retest was administered two weeks later to a 20% randomly selected subsample. Data analysis included reliability assessments and systematic modification of the instrument. Pearson's Product Moment Correlation and Kuder Richardson 21 analyses indicated the instrument is reliable when administered individually to children ages three-five. The authors recommended this instrument, or a similar picture identification instrument, be used to assess comprehensive health knowledge.

Achievement↗
PubMed1986

Designing chemotherapy and radiation therapy facilities.

Few disorders, regardless of their associated mortality rate, evoke the same degree of anxiety as that produced by cancer. Cancer treatment facilities should be designed to alleviate stress and provide comfort. This article addresses design considerations for selected areas of chemotherapy and radiation therapy facilities.

Hospital Departments↗
PubMed1985

Effect of dietary intake of fish oil and fish protein on the development of L-azaserine-induced preneoplastic lesions in the rat pancreas.

The effect of dietary intake of fish (menhaden) oil and fish (cod) protein on the development of pancreatic preneoplastic lesions was examined in male Wistar rats. Fourteen-day-old animals were given a single ip injection of 30 mg L-azaserine/kg body weight [CAS: 115-02-6; diazoacetate serine (ester)]. At 21 days of age they were weaned and maintained on dietary treatment for 4 months. Fish protein did not appear to produce a significantly different preneoplastic response when compared to casein as a protein source. However, a 20% menhaden oil diet, rich in omega 3 fatty acids, produced a significant decrease in the development of both the size and number of preneoplastic lesions when compared to a 20% corn oil diet rich in omega 6 fatty acids. This study provides evidence that fish oils, rich in omega 3 fatty acids, may have potential as inhibitory agents in cancer development.

Animals↗
PubMed1982

Recruitment from clinical studies.

Referrals from related clinical studies represent a recruitment source with a relatively low volume of initial contacts, moderate volume of entries, a high ratio of entries to initial contacts and a relatively low effort level requirement for the recipient recruitment team. In the CPPT, this source provided overall 1% of initial contacts, 9% of first protocol visits and 11% of entries. Referrals were obtained from three major clinical studies. Approximately two-thirds of the total entries from this source were derived from the Multiple Risk Factor Intervention Trial and almost three-fourths of these were accounted for by the Minnesota LRC. The recruitment campaign conducted at this center is highlighted. Recruitment costs were usually low with this strategy. The combination of low costs and high efficiency make clinical studies referrals attractive. Such referrals may not always be available, but if they are, every effort should be made to maximize their use.

Adult↗
PubMed1982

Population characteristics according to recruitment source.

Considerable variability was observed among recruitment sources and centers in the proportion of first protocol visits proceeding to entry. Some of the reasons for these differences are explored. Several characteristics of the participants were also analyzed to determine whether significant variability existed among recruitment sources. The variability encountered suggests that these characteristics might be exploited in selecting recruitment sources for clinical trials.

Adult↗