Erythromycin and valproate interaction.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to F Petito.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Eosinophilic meningitis is rare in Hodgkin's disease. Five previous cases have been reported. We describe an additional patient whose CSF showed an eosinophilic pleocytosis with Reed-Sternberg cells while in complete systemic remission from Hodgkin's disease. The patient responded to intrathecal administration of methotrexate given by Ommaya reservoir. Six months later, systemic relapse occurred, but the CSF remained normal. Eosinophilic meningitis is a treatable complication of Hodgkin's disease, and prolonged response is possible.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Isometric twitch contractions have been studied in extensor hallucis brevis muscles of 32 healthy male subjects aged between 3 and 25 years. The maximum twitch tensions were found to increase gradually with age and then to undergo marked enhancement at puberty. After puberty little further change occurred. In the youngest children examined the twitch contraction times were already within the adult range, though the half-relaxation times were prolonged.
Physiological studies have been made of extensor digitorum brevis muscles in 28 healthy subjects aged between 60 and 96. Within this elderly population there was evidence of muscle wasting and weakness. These changes were shown to result from a loss of functioning motor units. The surviving motor units were often enlarged and tended to have relatively slow twitches. In some subjects the maximum impulse conduction velocities were reduced in motor nerves; there was evidence that slowing of impulse conduction could be especially marked in distal regions of axons. The findings are considered to indicate the presence of motoneurone dysfunction in old age.
Explore the source record for details and available documents.
A twenty-five year old woman suffered the acute onset of dysequilibrium followed by headache, nausea, vomiting, vertigo, and slurred speech while swimming. Brain imaging revealed a right cerebellar infarct. Intravenous digital subtraction angiography showed a hypoplastic right vertebral artery and focal narrowing of the dominant left vertebral at the level of the C1-C2 junction. The patient was treated with aspirin and dipyridamole and immobilized for two weeks. She achieved almost complete recovery. Repeat angiography showed resolution of the left vertebral artery defect. Other cases of posterior circulation infarction associated with head turning during sports and ordinary activities are reviewed.