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Biomedical subjects

F Philip

Publications and source records attributed to F Philip.

29 records · Page 2Linked to original sources
PubMed1981

[Effects of dopamine on cardiac and hepatic index in man (author's transl)].

Dopamine is known to increase cardiac output and, to a greater extent, renal blood flow. The purpose of this study was to find out whether renal blood flow is increased partly at the expense of splanchnic blood flow. The splanchnic blood flow was evaluated by measuring, according to Fick's principle, the estimated liver blood flow during a continuous infusion of indocyanine green. Each determination was coupled with a measurement of the cardiac output, using a thermodilution method. The results were corrected to body surface, thus providing a cardiac index (Cl) and a hepatic index (Hl). The study involved 10 subjects free from hepatic, haemodynamic or haemorrhagic disease and was carried out in 3 stages: determination of initial values, then of values under dopamine (10-12 micrograms. kg. min) and finally, control of return to initial levels. The results showed that dopamine produced a significant (p less than 0,01) increase in Cl (mean 44%) and an equally significant (p less than 0,01) increase in Hl (mean 66%), the difference between the two increases being also significant (p less than 0.05). There was a strong correlation between Cl and Hl during dopamine fusion.

Cardiac Output↗
PubMed1981

Increase in hepatic blood flow and cardiac output during dopamine infusion in man.

The object of this paper was to evaluate the effect of a continuous dopamine infusion (10--12 micrograms/kg . min) on the estimated hepatic blood flow (EHBF) and cardiac output (CO) in man. Measurements were made in 3 periods: the initial control state, during dopamine infusion, and after the infusion. The CO (by thermodilution) and EHBF (by hepatic vein sampling after continuous indocyanine green (ICG) infusion) were measured during each phase. Ten subjects, with inapparent hepatic disease, hemorrhage, or hemodynamic anomalies, were studied. The results showed a 64% increase in the EHBF and a 49% increase in the CO. All subjects showed a return to the original baseline state after infusion. The EHBF/CO was 14% in the control period, 17.3% during infusion, and 13.4% after dopamine infusion. These changes were not statistically significant. Dopamine, therefore, increased both EHBF and CO, but the existence of intrahepatic dopaminergic receptors could not be established.

Cardiac Output↗
PubMed1978

[E.E.G. recordings during the course of a rare disease: piroplasmosis (author's transl)].

Two E.E.G. recordings were made in a patient with human piroplasmosis (babesiosis). They showed signs of vigilance disturbances and generalized abnormalities, together with lateralization in the temporal region, on the right side in the first recording and on the left in the second one. These abnormal E.E.G. findings are reported, even though the clinical signs were not typical of babesiosis, as the biological diagnosis was certain (parasite definitely identified in the red blood cells, severe and progressive parasitic infestation), and it is impossible to evoke other aetiological elements. It is impossible to formulate a valid hypothesis, based on our present knowledge, to explain the mechanisms of this encephalic condition. We can only state the findings without prejudging its direct or indirect nature.

Animals↗
PubMedDate not supplied

Value of phlebography for diagnosis and treatment of pulmonary embolism.

The frequency of recurrencies and of post-phlebitic syndrome after PE lead the Authors to perform phlebography of the legs before and after treatment of PE. A venous thrombosis was found in 124 cases out of 144 recent PE proven by angiopneumography. The thrombosis affected the ilio-caval veins 43 times, in 27/103 severe PE cases (24%), in 16/33 moderate PE cases (40%). Patients were treated: by H. in 67 cases; 33 (group I) with moderate PE, (4 (group II) with severe PE; by Streptokinase (SK) 24 times: 5 cases with moderate PE, 19 (group III) with severe PE; but U.K., high dose (UKf) 19 times; by U.K., moderate dose (UKm) 40 times, 3 cases with moderate PE, 37 cases (group V) with severe PE. After treatment, the mean volume of the venous clot, measured by the Marder's index, decreased in all groups. However, S.K. lysed 7 out of 17 proximal thrombosis, whereas the other treatments were unefficient. Failures were less frequent with S.K. (3/16) than with U.K. f (11/15), U.K.m (12/28) and H. (29/65). Recurrency was noticed 8 times: in 7 cases, it was seen in patients affected with proximal V.T. and not treated by I.V.C. interruption. Such facts warrant the systematic search for V.T. when PE is suspected. They justify the use of thrombolytic drugs not only for severe PE, but also for moderate PE which are associated to a proximal V.T.

Adolescent↗