Cost of treating birth defects in State Crippled Children's Services, 1975.
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Adolescent↗
Biomedical subjects
F Piazza
Publications and source records attributed to F Piazza.
[Neuropsychiatric development of children with acquired immunodeficiency].
The Authors describe the neuropsychological evolution of 88 children (86 born from HIV infected mothers and, 2 infected by blood products) followed up at the Institute of Infectious Diseases of the University of Pavia. All patients had a clinical, serological and immunologic evaluation done by a pediatric infectivologist and a neurological assessment (Amyeli-Tison and Towen) done by a pediatric neurologist every three months. The Mental Development was examined using the Griffith scales. Electroencephalographic, TC scan, liquor test and other invasive tests were done only in symptomatic patients when indicated. The incidence of Central Nervous System involvement by HIV virus was 24% in infected patients and 37% in children with symptomatic HIV infection; neurological symptoms were observed in coincidence with worsening of AIDS disease. Fifty-five percent of the patients had a serious developmental delays. The Authors stress the importance of an early psychological care of these patients done by a specialist physician in order to reduce the onset of developmental problems in children facing a life expectancy longer than before due to the continuous improvement in the therapeutic management of AIDS.
Acquired Immunodeficiency Syndrome↗
[Neurological manifestations in HIV-infected child].
The authors describe the main epidemiological, pathogenetic and clinical features of HIV-related encephalopathy in 50 pediatric patients (36 females, 24 males), born to HIV-seropositive mothers or infected by contaminated blood, observed in the Institute of Infectious Diseases of Pavia, between January 1984 and December 1994. All the patients (age 1 day-7 years) received a comprehensive evaluation, including subsequent neurodevelopmental assessments, by a multidisciplinary équipe of pediatric infectivologists and neuro-psychiatrists: the follow-up ranges from 6 months to 8.5 years. To evaluate the role of potentially covariates in HIV-vertically infected children, some maternal, gestational and perinatal factors were investigated. The neurodevelopmental assessment was carried out by a standardized protocol: tests were always conducted and evaluated by the same examiner. Seventeen pediatric patients with HIV-related neurologic impairment were observed (34%): 16 cases of encephalopathy (static-stable = 4, plateau = 6, subacute-progressive = 5, uncertain origin = 1) and 1 case of neurotoxoplasmosis. Findings of the current study demonstrate the high frequency of neurological impairment in HIV-infected infant/child, a worse evolution in this kind of patients and the effectiveness of an antiretroviral therapy only if administrated in the early phases of the disease. It was also emphasized the pathogenetic role of some covariates poorly evaluated in previously reported studies.
AIDS Dementia Complex↗
[Neuropsychological development of children born to HIV-positive mothers].
138 children born to HIV infected mothers (58 HIV infected and 80 seroreverted uninfected) were followed up at the Institute of Infectious Diseases of the University of Pavia. All patients had an evaluation of neurological assessment every three months done by a pediatric neurologist (Amiel-Tison and Towen) and an evaluation of psychological assessment by observation of child-mother interaction. The development quotient was examined using the Griffiths Scales and mental development using the Wisc-R scale. The incidence of Central Nervous System involvement was 36% in children with symptomatic HIV infection, the hump of incidence of severe encephalopathy was in the first 4 or 5 year of life, another hump (smaller) was in preadolescence. Development deficit and psychological problems were discovered both in asymptomatic infected and in non infected children, without difference of percentage between the two groups.
Acquired Immunodeficiency Syndrome↗
[Multiple organ system failure: analysis of oximetry parameters among survivors and non-survivors].
The authors have studied the relationship between SvO2 and many parameters of oxygenation in MOSF patients specially in surviving patients and not surviving ones. They found that there is a close correlation between SvO2 and CI in the survivors indicates that, in these patients, we can increase cardiac activity to improve the cellular demand.
Adult↗
[Neuropsychic development in children born with spina bifida].
The authors present the outcome of 42 patients operated at birth for closure of the spinal malformation. The age of patients at first observation ranged from 3 months to 21 years (mean 8.3 years); 7 patients (16.7%) had a close spina bifida, 35 (83.3%) had an open spina bifida and 30 (85.7%) of them developed hydrocephalus. The protocol included neurological evaluation, determination of development quotient using the Griffith's scale and intelligence quotient using the Wise-R scale. Adolescents underwent also the Blacky pictures test and Offer's interview. Verticalization and tutorial deambulation were achieved in 95.2% of patients; 76% of patients had a I.Q. > 90. The emotional situation was unsatisfactory in the majority of patients due to reduced autonomy and limited self-consideration.
Adolescent↗
[Course of mother-child relations in cases of maternal HIV infection].
32 children born from HIV infected mothers (8 HIV infected and 24 seroreverted uninfected) were followed up from 1990 to 1995 at the Neurological Institute "C. Mondino" in Pavia to study the mother and baby relationship. At the end of the follow-up period, from the birth to the end of the second year of age, all children had psychosomatic disorders (repeated rejections, anorexia, sleep disturbances characterised by difficulty in falling asleep and frequent wake-ups, gaseous colics many times during the day). The psychosomatic disorders are considered as the result of an early distortion of the mother and baby relationship. Thus children born from HIV positive mothers are exposed to the possibility of developing psychological problems related to a distorted relationship with their mother.
Age Factors↗
[Cholesterol granuloma of the petrous apex].
Cholesterol granuloma of the petrous apex is a relatively rare tumor, and usually is not associated with middle ear pathology. Precise assessment of the diagnosis and extension allows the surgeon to plan the most appropriate and functional strategy. The advent of magnetic resonance imaging has helped, showing a high signal in T1 and T2 without enhancement after the administration of intravenous paramagnetic contrast. The occipito-temporal approach provides direct access to the anterior and posterior petrous apex without opening the dura, which preserves the facial and the cochlear-vestibular functions.
Adult↗