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Biomedical subjects

F Pinet

Publications and source records attributed to F Pinet.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

Emergency selective aortography for acute lesions of the thoracic aorta.

Emergency selective aortography is necessary for the definitive diagnosis of acute lesions of the thoracic aorta and defines their therapeutic possibilities. Cineradiography is very helpful and is complementary fo the roentgenograms. In this paper the study of dissecting aneurysms, tears of the aortic wall, ruptured aortic aneurysms and traumatic aortic lacerations is described. A new anatomic classification of dissecting aneurysms combined with that of De Bakey et al. is presented.

Aorta, Thoracic↗
PubMedDate not supplied

Regulation of human renin gene transcription by cAMP.

To delineate the cis-acting elements of the proximal promoter responsible for cAMP-induced human renin gene transcription, 5'-flanking regions of the human renin gene were fused to a luciferase reporter gene and transfected in chorionic cells. Forskolin treatment induced the expression of luciferase by 2.4 fold when the reporter plasmid contained the promoter region (-582 to +16). Mutation or deletion of the CRE diminished (1.7 fold) but did not abolish cAMP-induced transcription, demonstrating that region containing the CRE and region containing a Pit-1 site were both necessary for cAMP maximal induction. Taken together, these results show that the cAMP response of the human renin gene may involve CREB binding the CRE and tissue-specific factors (from chorionic and kidney cell origin), different from Pit-1, that interact with the Pit-1 response DNA elements.

Base Sequence↗
PubMedDate not supplied

[Contribution of proteomic analysis to study cardiovascular physiopathology].

Proteomic is an innovative approach for determining without any priori the coordinated changes in protein levels contained in a biological sample. This technique now constitutes a powerful tool for revealing, in particular by differential analysis, biological responses and regulation of proteins. This field is becoming essential in each domain for fundamental and clinical biology, mainly in human medicine. It leads to improve the understanding of complex physiopathological processes like those involved in human pathologies, but also for identifying new biomarkers in order to consider new diagnostic and prognostic approaches and original therapeutic targets. The different proteomic techniques, essentially bi-dimensional electrophoresis and mass spectrometry, which benefit from recent technological developments, are presented in this article. A literature review summarize data obtained from proteomic works performed to have better understanding of mechanisms involved in cardiovascular diseases, first cause of morbidity and mortality in the world. Proteomic analysis performed in this area of research are promising, because of the lack of knowledge in the molecular interactions and the complexity of mechanisms involved, and of the impact of environmental risk factors. This impact is being generally only detectable at protein level. These works are only at the beginning and these approaches applied in cardiovascular field will meet a large success in the immediate future and should be promising.

Cardiovascular Diseases↗
PubMedDate not supplied

Cine-angiography during percutaneous transluminal angioplasty of the lower limbs.

In the treatment with percutaneous transluminal angioplasty of 65 atheromatous stenosis of the lower limbs including 50 iliac and 15 femoro-popliteal lesions, the authors insist on the value of cine-angiography during the dilatation. Cine-angiography increases the security and the velocity of the examination. The anatomic data of this technic are as precise as those obtained with seriography and a special hemodynamic investigation is obtained with the direction of the flow of the contrast medium in the collateral branches and in the main artery. The cost is less expansive than with seriography.

Angioplasty, Balloon↗
PubMedDate not supplied

[Primary tumors of the diaphragm. Apropos of a case].

The diagnosis of diaphragmatic tumours is complicated by their rarity and because they are often difficult to distinguish from the more frequent tumours of surrounding structures. We describe two cases: an invasive fibroma and a primary hydatid cyst. We discuss the differential diagnosis of diaphragmatic tumours and suggest a systematic approach to their radiological diagnosis, stressing the value of ultrasonography, CT scanning and diagnostic pneumoperitoneum.

Aged↗
PubMedDate not supplied

[Acute aortic dissection. Prognostic factors, therapeutic indications. 137 cases (author's transl)].

137 patients (92 men and 45 women) with an average age of 58 years (range: 19 to 90 years) were hospitalised between January 1970 and June 1977 for acute aortic dissection. In 107 patients (and in 91 cases during the first 24 hours of hospitalisation) aortography was performed. This examination was found to be greatly reliable when its findings were compared with those at surgical exploration. In the absence of surgical treatment, 69 patients died and 5 survived. Amongst the patients undergoing surgery, 37 died and 27 survived. With the exception of type III dissections, survival appeared to be markedly increased by surgical treatment. Preoperative factors indicative of a poor prognosis included a neurological deficit of central origin, oligoanuria, raised blood urea, disseminated intravascular coagulation and dissection of the superior mesenteric artery or the coeliac trunk.

Acute Disease↗