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F Pons Romero

Publications and source records attributed to F Pons Romero.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Cell-mediated and humoral immunity in ulcerative colitis. Acute phase reactants (author's transl)].

Many findings suggest that the alterations in immune response observed in intestinal inflammatory diseases may play a part in their pathogenesis. This observation led us to study 22 patients with chronic ulcerative colitis, of whom seven were in the acute stage and the other 15 were asymptomatic. The T and B lymphocyte populations were determined as well as the serum levels of immunoglobulins and acid alpha-1-glycoprotein as acute phase reactants. The results were compared with those obtained from a control group of 10 normal individuals. No statistically significant differences were observed in the percentages and absolute values of T and B lymphocytes as compared with the controls. nor in relation to the activity of the lesions. Neither were there any observable variations in the serum concentrations of immunoglobulins. On the other hand, analysis of the acid alpha-1-glycoprotein showed highly significant values as related to the degree of activity of the inflammatory lesion (p less than 0.005). Our results confirmed the value of determining serum acid alpha-1-glycoprotein levels as an index of inflammatory activity. The immunitary parameters under study did not vary in the different stages of the disease.

Adult↗
PubMedDate not supplied

[Intestinal bacteria overgrowth in chronic hepatopathies].

Intestinal bacterial overgrowth (IBD) is very frequent in patients with chronic hepatopathies. Causes of IBO, although not entirely known, principally are: the hepatopathy, the alcoholism and the alterations produced by these two factors, such as achylia (and above all hypochlorhydria), decrease in the secretion of IgA, and malnutrition. On the other hand, the IBO increases the severity of the hepatopathy and frequently produces a bacterial peritonitis. All these data suggest that the IBO play an important role increasing the hepatopathy severity and consequently is a factor to bear in mind.

Achlorhydria↗
PubMedDate not supplied

Role of prostaglandins on lymphocyte transformation in Crohn's disease.

We analyzed the response to phytohemagglutinin (PHA) of peripheral blood (PBL), intraepithelial (IEL) and lamina propia (LPL) lymphocytes in eight patients with Crohn's disease (CD). We also studied the effect of indomethacin, a prostaglandin synthetase inhibitor, and monocyte depletion on mitogen-induced stimulation of these cells. The blastic stimulation index was significantly lower in PBL and intestinal mucosa lymphocytes of CD than in controls (p less than 0.001). This index increased after addition of indomethacin in PBL and LPL and after monocyte depletion in PBL. The suppressor index on blastic stimulation, obtained when indomethacin had been added to the cultures was higher in PBL and intestinal mucosa lymphocytes of patients with CD than in controls. After monocyte depletion, this suppressor index decreased significantly in PBL and did not change in controls. These data suggest that prostaglandins could be one of the responsible factors for hyporesponsiveness of lymphocytes in CD.

Adult↗
PubMedDate not supplied

Loss of suppressor T cell function and circulating immune complexes in alcoholic cirrhosis.

In the present work Concanavalin-A-induced T suppressor function has been studied in 28 patients with active alcoholic cirrhosis and 22 patients with inactive cirrhosis. Control subjects were 14 alcoholics without liver disease and 70 healthy individuals with normal liver function tests. Suppressor T cell function was decreased in active alcoholic cirrhosis whereas this change was not observed in inactive cirrhosis nor in alcoholics without liver disease. The suppressor T cell activity of normal individuals was inhibited by heat-inactivated serum pretreatment of patients with alcoholic cirrhosis. The data suggest that there is some kind of serum factor in alcoholic cirrhosis able to affect lymphocyte suppressor activity. No linear correlation could be established between serum level of circulating immune complexes (CIC), determined by solid-phase C1q-binding assay, and suppressor T cell function. There were no differences between sera of alcoholic cirrhosis patients with or without CIC regarding their inhibition of suppressor T cell activity of normal individuals. These results suggest that these serum factors are not related to the presence of CIC.

Adult↗
PubMedDate not supplied

Intestinal and peripheral blood lymphocyte subpopulations in Crohn's disease.

Cellular immunity has been implicated in the pathogenesis of Crohn's disease. In the present work, we have studied T-lymphocytes subsets in peripheral blood and intestinal mucosa of eight patients with active disease, using monoclonal antibodies. Intraepithelial and lamina propia OKT-3 +ve cells were significantly lower than in peripheral blood (p less than 0.001). We have found an increase of B cells and OKT-8 +ve cells in intestinal mucosa with a significant decrease in helper/suppressor ratio. These findings are in accordance with a high suppressor-cytotoxic function in patients with active diseases.

Adolescent↗