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Biomedical subjects

F Provot

Publications and source records attributed to F Provot.

6 recordsLinked to original sources
PubMed1999

Changes in growth factor and cytokine mRNA levels after hepatectomy in rat with CCl(4)-induced cirrhosis.

Cirrhotic liver is considered to regenerate less actively than normal liver after hepatic resection. However, the mechanisms responsible for this impaired regeneration and the cross talk of implicated factors still remain unclear. In the present study, mRNA levels for cyclins, growth factors, and cytokines were quantitatively assessed by a RT-PCR method at different times after hepatectomy in order to determine the relationships between these factors and the impaired regenerative process observed in cirrhotic liver. In our model of CCl(4)-induced cirrhosis, mRNA levels for cyclins and thymidine kinase provide evidence for the impaired and delayed hepatic regeneration. Moreover, we observed a significant decrease in interleukin (IL)-6 and tumor necrosis factor-alpha mRNA and a significant increase for IL-1beta mRNA. No significant change of hepatocyte growth factor (HGF) mRNA level was detected, contrasting with the decrease both at mRNA and protein levels in the expression of the c-Met/HGF receptor. Therefore, the impaired regeneration of the cirrhotic liver is associated not only with a lowered level of signals that normally promote liver growth but also with a strong decrease in c-Met receptor despite a normal expression of its specific ligand.

Animals↗
PubMed1999

[Bartter's syndromes].

Bartter syndromes are defined as a family of inherited recessive autosomal tubulopathies. They are characterized by hypochloremia, hypokalemia, metabolic alkalosis associated with potassium renal leakage and normal blood pressure despite increased plasma renin activity. Three forms of the disease are identified as followed: 1) Gitelman syndrome or hypocalciuria hypomagnesemia syndrome is a mild form often discovered in childhood or teenagers in reason of tetany. It is an homogeneous disorder related to mutations of the genes encoding the thiazide-sensitive Na-Cl cotransporter located in the distal convoluted tubule. 2) Antenatal Bartter syndrome with hypercalciuria and nephrocalcinosis or hyperprostaglandin E syndrome is a severe form, often revealed by hydramnios, prematurity and growth delay. It is related to mutations of two types of genes encoding for transporters of Henle's loop: the bumetanide-sensitive cotransporter Na-K-2Cl (NKCC2) [type I] or the inwardly-rectifying potassium channel (ROMK) [type II]. 3) the classical form or type III Bartter syndrome, often revealed by dehydration in the first year of life, is associated with hypomagnesemia in 20% of cases and normal or increased calciuria. This form is related to mutations of CLCNKB gene encoding for a chloride channel in Henle's loop. This classification, in part related to the demonstration of mutations in the genes encoding for tubular chloride or potassium channels, does not fit all cases, overlapping syndromes are frequent. Moreover some endocrinological (diabetes) and neurological (deafness) abnormalities are sometimes associated with Bartter syndromes. Both phenotypic and genetic approach must help to the diagnosis of these tubulopathies.

Bartter Syndrome↗
PubMed1984

[Changes in plasma parameters in rabbit does as a function of their physiological state and feed rationing].

We followed the evolution of hematocrit and of plasma Na, K, Cl, total protein, creatinine, Pi, alkaline phosphatases, triglycerides, cholesterol, glucose and GPT. The amount of feed given to the rabbit does was restricted to 75 percent of the quantity eaten ad libitum, in similar conditions to those of intensive breeding. This had a slight effect on the values obtained for plasmatic components in healthy rabbits. This was not dependent on the timing of blood collection, nor on the physiological state of the animal. The changes in biochemical composition of the plasma due to pregnancy in healthy rabbit does are: a fall in total plasma protein and cholesterol levels, alkaline phosphatases activity, hematocrit, and a rise followed by a marked fall in plasma triglycerides level. During lactation, these levels return progressively to the values obtained in non-pregnant, non-lactating rabbits.

Alanine Transaminase↗
PubMed1984

[The pathology of ther reproducing female rabbit: a comparative, descriptive study of morbidity phenomena observed during the reproduction o purebred strains of rabbit].

We analysed the working life of purebred New Zealand, and Californian rabbit breeding does kept in identical conditions. Our study notes the health of the does as well as various factors affecting the survival rate of baby rabbits until weaning. After the first six months of rearing the productivity and the health of the two breeds were very different. The Californian females came through their first two gestations and lactations very well but more than half of them showed signs of respiratory ailments, and many had to be eliminated. Their first two litters were characterised by a low number of baby rabbits weaned as well as a large number of whole litters dead before weaning. The females of the New Zealand breed were in good health but then died suddenly at the end of gestation or in the middle of lactation; the surviving females raised practically their whole litter until weaning. The loss of animals is numerically fairly similar in the two breeds but takes on different farms. This comparative study of the elimination of the does, of their mortality, or of that of the baby rabbits during lactation leads us to the hypothesis that these three phenomena are probably different manifestations of the same pathological phenomena occurring early on, probably from the first gestation onwards.

Animals↗
PubMed1983

[Pathology among breeding does. Evolution of several plasma parameters among primiparous rabbit does].

One of the most important limiting factors of rabbit production is reproductive pathology. This pathology has two aspects: livestock reduction (elimination and death of rabbit does) and mortality of young rabbits before weaning. We studied alterations of hematocrit and of plasma Na, K, Ca, Mg, Pi, total proteins, prolactin, during gestation and lactation of primiparous rabbit does. In females which were going to die the first results showed a fall in plasma NaK, Ca concentrations and a rise in plasma Mg. We think that these alterations are only consequences of anterior metabolic alterations and are indicators or secondary causes of the animal's proximate death. We noticed a deep fall in plasma prolactin concentration before death; its signification is discussed. In the females which did not wean their whole litter, average prolacting levels during gestation and at the beginning of lactation were lower than in females weaning their whole litter. These first results would confirm the hypothesis that youngs' mortality is a pathology linked with dams' state.

Animal Diseases↗