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F Pugliese

Publications and source records attributed to F Pugliese.

139 records · Page 8Linked to original sources
PubMedDate not supplied

[Exposure to acetone: experimental study of absorption and pulmonary elimination in normal subjects].

Alveolar (CA) and mixed expired air (CE) acetone concentrations were measured in 15 healthy volunteer subjects, exposed to acetone (CI) in an exposure chamber (exposure range: 48-565 mg/m3) both at rest and during exercise (50 W). The Relative Uptake (R = 1-CE/CI) was 0.54 at rest (120' and 240') and 0.55 during exercise (120', 50 W). Ca:CI ratio was 0.24 at rest. CE:CI and CA:CI ratio was constant throughout the exposure time, both at rest and during exercise.

Acetone↗
PubMedDate not supplied

[Antidepressive prevention with lithium salts: possible interaction with occupational exposure to nephrotoxic substances].

Forty-four patients suffering from depressive disorders treated with lithium have been subdivide in two groups. One of groups included subjects with previous working anamnesis of exposure to renal toxic agents. The differences of renal function between the two groups have been considered. Significant differences of glomerular and tubular function have been found. These findings permit to hypothesize a synergism between lithium and nephrotoxic agents.

Adult↗
PubMedDate not supplied

The role of prostaglandins in the control of renal function: renal effects of nonsteroidal anti-inflammatory drugs.

This review examines the role of renal PGs in regulating glomerular function (RBF and GFR). The bulk of available evidence suggests that the glomerulus is the target structure for many vasoconstrictor agents, which stimulate renal synthesis of vasodilator PGs. PGE2 and PGI2 may regulate GFR and RBF by modulating either the vasoconstrictor actions on arterioles or the contractile activity of these agents on the glomerular mesangium. NSADs inhibit renal PG-synthesis at usual therapeutic dosage. In normal man these drugs appear not to affect GFR and RBF. In a number of renal ischemic states sustained by either exaggerated vasoconstrictor stimuli to the kidney or local reduction of vasodilator PGI2 synthesis, NSADs may exert deleterious effects on renal function. Selective sparing of renal cyclo-oxygenase activity of sulindac makes this drug safe in patients with severe cardiac, hepatic or glomerular disease.

Animals↗
PubMedDate not supplied

[Acute poisoning by Vantal (combination of dimethoate and DDT) in a group of longshoremen].

In this work the authors describe a case of acute intoxication by "VANTAL" (DDT and Dimethoate) occurred in a group of six longshoremen. The authors particularly consider the reports about the gastroenteric apparatus and the central and peripheric nervous system. It has in fact been possible to document all kinds of pathologic condition from gastritis to duodenal ulcer in all subjects; whereas only three subjects out of six showed alterations in E.E.G. and E.M.G.

Adult↗
PubMedDate not supplied

Cyclic nucleotides inhibit Na+/Ca2+ exchange in cultured human mesangial cells.

Na+/Ca2+ exchange contributes to the control of cytosolic free Ca2+ levels ([Ca2+]i) in resting and activated cultured human mesangial cells. We have previously shown that activation of phospholipase C by vasoconstrictors enhances Ca2+ influx upon extracellular Na+ withdrawal. This effect is not mediated by concurrent activation of protein kinase (PK) C, since it occurs even after PKC inhibition, and phorbol esters actually blunt both basal and stimulated Na+/Ca2+ exchange. We now studied the effects of PKA and PKG activation by adenylate/guanylate cyclase stimuli or by permeant analogues of cyclic nucleotides in monolayer cultures loaded with the fluorescent Ca(2+)-sensitive probe, fura-2. The exchanger was inhibited by the stable prostaglandin I2 analogue, iloprost, which is transduced by cAMP (peak [Ca2+]i inhibition by 1 microM iloprost 35 +/- 3%). Similarly, non-receptor activation of adenylate cyclase by 10 microM forskolin inhibited basal and agonist-stimulated Na+/Ca2+ exchange by 52 +/- 4 and 66 +/- 4%, respectively. Dibutyryl-cAMP (0.1 mM) also inhibited stimulated Na(+)-dependent Ca2+ influx by 72 +/- 2%. The particulate guanylate cyclase agonist, atriopeptin III, and the soluble guanylate cyclase activator, glyceryltrinitrate, also inhibited both basal and angiotensin II-stimulated Na+Ca2+ exchange (to a maximum of 53 +/- 5 and 62 +/- 3%, respectively). Dibutyryl-cGMP (1 mM) mimicked the effects of cGMP stimuli, reducing stimulated Na+/Ca2+ exchange by 79 +/- 2%. Therefore, similar to PKC, cyclic nucleotide activation of PKA and PKG regulates Na+/Ca2+ exchange, providing a functional link between transmembrane signalling systems for vasoactive agents in cultured human mesangial cells.

1-Methyl-3-isobutylxanthine↗