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F Pulido

Publications and source records attributed to F Pulido.

46 records · Page 3Linked to original sources
PubMed1993

[Thromboangiitis obliterans (Buerger's disease). Study of 41 cases].

BACKGROUND: The aim of this study was to know the prevalence, clinical and immunological characteristics and evolution of thromboangiitis obliterans. METHODS: Between 1982-1990 41 cases of thromboangiitis obliterans were diagnosed from among 373,899 patients registered (11/100,000) according to the clinical and arteriographic criteria. Of these 41 cases 40 were males with mean age 36 +/- 7 years (mean +/- SD) with only two cases being over 45 years of age. In 40 cases was followed for 44 +/- 29 months (mean +/- SD). RESULTS: All the patients had ischemia of the lower limbs, 34% of the upper limbs, 39% superficial thrombophlebitis, 53% Raynaud's phenomenon, 5% mesenteric ischemia, and 7% myocardial infarction. In 30 symptomatic patients anticardiolipin antibodies were determined and one patient was positive for IgG antibodies. In the 23 patients in whom HLA and anticollagen antibody studies were performed a significant increase was found in HLA-B35, HLA-B40 and type VI denaturalized anticollagen antibodies compared to controls. In general the evolution was progressive when the patients continued smoking and favorable when tobacco was given up except in 2 cases who stopped smoking and in whom the disease progressed and death occurred. The total number of patients who died during follow up was 3 (7%), 2 due to mesenteric ischemia and the third during i.v. infusion of PGE1. CONCLUSIONS: The results demonstrate that thromboangiitis obliterans is a rare disease in Spain. The involvement of visceral arteries is not very infrequent with worse prognosis when the mesenteric arteries are involved. There is a significant increase of determined HLA antigens and anticollagen antibodies in the patients with thromboangiitis obliterans.

Adult↗
PubMed1991

[Signet-ring cell colorectal carcinoma. Study of 2 cases].

The signet-ring cell colorectal carcinoma is very uncommon. During the period 1985-89, we have diagnosed two cases among 1,135 adenocarcinomata located in the same place. They are the two first cases described in Spain, according to a computerized bibliographic search. We have to point up as clinical features of the tumor, the occurrence of its first signs in advanced stages of the disease and the small survival of the patients suffering from this tumor. Its great content of mucin facilitates the thromboembolic disease which was the first sign and the cause of legth in one of our patients. This type of tumor has worse prognosis than the usual colorectal carcinomata, including the mucinous one, and it is similar to the one of the poorly differentiated carcinoma.

Adenocarcinoma, Mucinous↗
PubMed1989

[Histiocytosis of Langerhans cells: a study of 40 cases].

Forty cases of histiocytosis of Langerhans' cells (26 children and 14 adults) were evaluated; 20 were localized forms (with single or multiple bone involvement); another 20 were generalized forms, with organic dysfunction (lung, liver, hemopoietic system) in 7 children. This feature has a poor prognostic significance, as shown by the fact that 3 of these 7 patients died. In 3 patients single skin involvement was found, with spontaneous recovery one month after the diagnosis in one; in one case the single involvement was lymphadenopathic, associated to Hodgkin's lymphoma, and in another it was hypothalamic. These cases of single involvement have been followed up between 1 and 4 years. In 4 of 7 patients with generalized disease a reduction of OKT8 with an increased OKT4: OKT8 ratio was found, as reported in other cases from the literature. This finding gives support to an immunological rather than neoplastic basis for the disease. In all 40 cases the diagnosis was morphological, with positive staining for S-100 protein in 38.

Adolescent↗
PubMedDate not supplied

Study of the validity of a questionnaire to assess the adherence to therapy in patients infected by HIV.

PURPOSE: The purpose of our study was to examine the validity of a questionnaire to detect nonadherence in HIV-infected patients under antiretroviral treatment. METHOD: This was a cross-sectional study to validate a diagnostic test. Participants consisting of 242 HIV-infected patients were elected by consecutive sampling in a hospital in Madrid. The validation standard was the pharmacy dispensing records with the cut point being 80% and 90% of delivered drugs. Sensitivity (S), specificity (SP), positive predictive value (PPV), and positive likelihood ratio (PLR) of the questionnaire were estimated. RESULTS: The mean age of the participants was 36.2 years old (SE 0.42), 55% were men, and 68.2% had used parenteral drugs. Eighty-three patients (34.3%) did not reach 80% of the prescribed dose and 129 patients (53.3%) did not reach 90%. In the 80% group, S was 25.3% (95% CI, 16.7%-36.2%),SP was 86.2% (95% CI, 79.6%-90.9%), PPV was 48.9% (95% CI, 33.5%-64.3%), and the PLR was 1.83 (95% CI, 1.07-3.13). In the 90% group, the S was 19.4% (95% CI, 13.4%-27.4%), SP was 84.0% (95% CI, 75.7%-90.0%), PPV was 58.1% (95% CI, 42.4%-72.6%), and PLR was 1.22 (95% CI, 0.70-2.12). CONCLUSION: The proposed questionnaire is not a reliable diagnostic method to detect nonadherence. It should only be incorporated into the daily clinical practice along with other methods of nonadherence measurement.

Adult↗