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Biomedical subjects

F R Hendrickson

Publications and source records attributed to F R Hendrickson.

At least 73 records · Page 4Linked to original sources
PubMed1982

The palliation of symptomatic osseous metastases: final results of the Study by the Radiation Therapy Oncology Group.

Different dose fractionation irradiation schedules have been evaluated in a randomized Radiation Therapy Oncology Group (RTOG) study to determine their palliative effectiveness in patients with osseous metastases. The frequency, promptness and duration of pain relief were utilized as measures of response. Ninety percent of patients experienced some relief of pain and 54% achieved eventual complete pain relief. Important prognosticators included the initial pain score and the site of the primary lesions. Administration of steroid or chemotherapy during the one-month on-study period did not influence the frequency of pain relief. The low-dose, short-course schedules were as effective as the high-dose protracted programs.

Bone Neoplasms↗
PubMed1982

Fast neutron beam radiation therapy in the United States.

Following a 30-year hiatus after Dr. Stone's work in the 1930's and 1940's, clinical trials with fast neutrons were restarted in the United States in 1972. Approximately 2500 patients have been treated with neutrons since that time. Three hundred and seven patients with squamous cell carcinomas of the head and neck were entered on an RTOG-coordinated randomized study comparing standard photon irradiation with mixed beam radiation therapy. No significant differences were noted in the local control, survival or complication rates. One hundred and sixty patients were entered on a randomized glioblastoma study. Although there were no significant differences in median survival, autopsy results showed greater tumor effect on the neutron-treated tumors. Twenty-six patients were treated for transitional cell carcinomas of the bladder with either preoperative mixed beam irradiation or mixed beam irradiation alone. Both the local control rates and survival rates compare favorably with photon radiation therapy. The future of fast neutron beam radiation therapy in the United States is discussed.

Brain Neoplasms↗
PubMed1980

Results of re-irradiation for cerebral metastases.

After an initial course of radiation, 56 patients with cerebral metastases had their brain retreated at least once for recurrent neurologic symptoms. The most common primary was from either the lung or breast. The frequent symptoms were headache, weakness, seizures, visual problems, and/or mental changes. Forty-two (75%) of these patients responded to the second course of treatment. The median duration of response was 10 weeks and median survival was 14 weeks.

Adult↗
PubMed1980

Extranodal non-Hodgkin's lymphoma.

From 1964 to 1977, 42 patients with Stages I and II non-Hodgkin's lymphoma involving the extranodal sites were seen and treated with curative intent by radiotherapy in the Department of Therapeutic Radiology at Rush-Presbyterian-St. Luke's Medical Center. The initial pathologic specimen was reclassified according to the criteria of Rappaport et al. Diffuse histology was the most common histologic type found in 80% of the patients. The five-year actuarial survival and disease-free survival rates were found to be almost identical at 74% for Stage I and 38% for Stage II patients. The most common sites of origin were in the head and neck area in 19 patients and gastrointestinal tract in 15 patients. The sites of involvement in the head and neck area were many and varied, with parotid and nasal cavity being the most frequent. Survival rates and disease-free survival rates for different histologic types, various sites, and their patterns of recurrence are presented.

Gastrointestinal Neoplasms↗
PubMed1980

Late effects of para-aortic irradiation in carcinoma of the uterine cervix and endometrium.

Twenty-one patients with cervical or endometrial carcinoma and metastases to the para-aortic lymph nodes were treated with extended-field para-aortic irradiation. The late effects of this treatment were evaluated in 16 patients who had a minimum follow-up of six months. All of the patients with massive pelvic tumours died of active disease in the pelvis with or without metastases. Three patients had small-bowel complications; none of the patients who underwent exploratory laparotomy for lymph node biospy had bowel complications. The results indicate that patients with central lesions and minimal para-aortic disease benefit most from para-aortic irradiation. It is concluded that metastases to the para-aortic lymoh nodes do not necessarily indicate more distant spread, and can be cured with irradiation. The late complication rate can be minimized by reducing the dosage to the small bowel with a combination of anterior-posterior fields and 360 degree rotation or opposing lateral 120 degree arc fields, and by using the extraperitoneal approach for lymph node biopsy.

Abdomen↗
PubMed1979

Pattern of recurrences in endometrial carcinoma and their management.

During the period 1961-1971, 177 surgical candidates with clinical Stage I adenocarcinoma of the endometrium were treated. The pattern of recurrence according to the initial mode of treatment and the high risk factors predisposing to recurrence are presented. The incidence of vaginal vault recurrence was reduced from 7.4% with surgery to 1.2% by the use of adjunctive radiotherapy. Management of recurrence according to site is outlined. The local control rate for patients with local recurrence was 44% and the five-year survival rate after recurrence was 33%.

Adenocarcinoma↗
PubMed1978

Radiation therapy in the treatment of malignant salivary gland tumors.

A retrospective analysis of 52 patients with malignant salivary gland tumors is reported. Seventeen patients received early postoperative radiation therapy and 16 (94%) were free of local or regional disease 2-14 years following initiation of therapy, although 14 were considered at high risk of developing local recurrence. Two subjects (12%) developed distant metastases and 14 (82%) were completely disease-free. Survival and disease-free status of patients treated for recurrent or inoperable disease were much worse with two of 13 disease-free at 45 and 168 months respectively. Various workers have reported recurrence rates after surgery along at 25-38% and over 50% for many histological types. On the basis of this report early postoperative radiation therapy is recommended to reduce the risk of postsurgical recurrence. Prognostic trends relating to both histological type and location of primary disease are discussed.

Adenocarcinoma↗
PubMed1978

Carcinoma of the vocal cord: results of treatment and time-dose relationships.

A retrospective analysis has been done of 173 patients with epidermoid carcinoma of the vocal cord treated with radiation therapy at Rush-Presbyterian-St. Luke's Medical Center between January 1970 and December )974. one hundred fifty-eight patients (91.3%) were early (T1, T2) glottic lesion and 10 were advanced (T3, T4) lesion. Five (2.9%) were presented with positive cervical lymph nodes initially. Of 158 patients who had T1, T2N0M0 glottic tumor, 146 had definitive radiation therapy and 12 had preoperative radiation therapy. An analysis of frequency of local recurrence versus total dose (NSD) has been done for 146 patients and a dose response curve has been generated. Local failure rates were 22.2% for 1,800 +/- 50 rets, 11.1% for 1,900 +/- 50 rets, and 3.2% for 2,000 +/- 50 rets. For the early glottic cancer, local control rates were increased with increasing total dose without significant complications. In patients with advanced primary tumors, a greater number of the patients were treated with preoperative radiation therapy and this group had slightly better results.

Adult↗
PubMed1978

Analysis of pattern of recurrence in non-seminomatous testicular tumor.

In non-seminomatous testicular tumor, 60% of failures are seen within the first three months after diagnosis. The most common site of metastasis is the lung. Occasionally, bone, liver and brain metastases are seen. In this series of 33 cases, the definitively treated Stage I patients are alive and well for an average of 6.3 years (12 patients); one was lost to follow-up. The 20 more advanced patients have not done well--16 are dead from disease with an average survival of 17 months, 3 are alive with disease for an average of two years, and one was lost to follow-up. In Stages II and III, the best results were obtained with an aggressive multimodality approach of surgery, postoperative irradiation and chemotherapy.

Adolescent↗