Biomedical subjects

F R Karjodkar

Publications and source records attributed to F R Karjodkar.

3 recordsLinked to original sources

PubMed2006

Increased survivin expression in high-grade oral squamous cell carcinoma: a study in Indian tobacco chewers.

BACKGROUND: Oral cancer is one of the five leading sites of cancer in the Indian population. In the present study we analyzed the expression of apoptosis regulating genes, viz. survivin, Bcl-2, Bax and p53 in precancerous and cancerous lesions of the buccal mucosa of Indian tobacco chewers. METHOD: Paraffin-embedded tissue samples from 38 patients with primary oral squamous cell carcinoma (OSCC) and 17 patients with leukoplakia were used. The expression of survivin, Bcl-2, Bax, and p53 was evaluated using immunohistochemical staining method. RESULTS: Thirty-six percent OSCC were found to be positive for nuclear p53 staining while none of the precancerous lesions showed p53 positivity. Survivin, Bcl-2 and Bax expression was found to increase with increased grade of malignancy. Increase in survivin expression was statistically most significant (P < 0.001). CONCLUSION: Increased expression of anti-apoptotic survivin in high-grade tumors suggests that survivin is likely to contribute significantly to apoptosis resistance in response to therapy.

Adult↗

PubMed1990

Use of cephalometry in diagnosing resonance disorders.

A comparative cephalometric study of the oronasopharyngeal dimensions was carried out on 20 patients with normal speech, 20 patients with nasality and 22 patients with cleft palate speech, with the help of cephalometric landmarks given by Proffit and McGlove, Proffit et al., and Ricketts. The data obtained were subjected to statistical analysis, to determine whether there were any significant changes in oronasopharyngeal dimension between the various groups. It was concluded from the obtained data that there was an increase in the width and depth of the nasopharynx, with a consequential increase in the pharyngeal cavity volume in patients with cleft palate speech when compared with patients who had normal speech and those who had nasality.

Adolescent↗

PubMedDate not supplied

The intriguing shadow.

In the field of radiodiagnosis shadows often raise doubts. On these depend the invasive investigative procedures which lead to the final diagnosis. The radiologist's word is often considered as the last word in labeling a lesion. The treatment protocol which follows makes a world of a difference to the patient. We report interesting cases where the patients were radiographed prior to orthodontic treatment and coincidentally we found-un believable hidden treasure! This is a modest attempt to emphasize that each shadow in a radiograph should be scrutinized. Needless to say, the keen observation and experience of the diagnostician is of penultimate importance in deciphering the abnormal from the normal.

Journal Article↗