Biomedical subjects
Publications and source records attributed to F R Sarkisova.
Benign tumours of the laryngopharynx are mainly vascular tumours. Thirty two persons with the given pathology were under observation. The main clinical symptoms of the disease are the appearance of blood in the sputum, dysphonia, dyspnea of different degree. The method of choice is radical surgical intervention including tracheotomy, laryngotomy, transverse and lateral pharyngotomy, ligation of the external carotid artery.
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Correction of the immune status is one of the burning problems of current otorhinolaryngology. Recent developments in immunology allow interference at the cellular level. However, otorhinolaryngological practice is still based on oral, parenteral or local use of ineffective drugs. This paper presents early results of the application of extracorporeal cytapheresis combined with the modulator treatment of lymphocytes for the surgical therapy of 25 patient with ENT malignant neoformations of different stage and localization. Leukocytapheresis, i. e. separation of leukocytes, was performed by means of an Aminco (USA) or FK-3,5 (USSR) cell separator and the separated cells were treated with diuciphone. This method yielded good results as suggested by immunological, immunochemical, biophysical, and cytological measurements of blood. The method seems promising for ENT-cancer therapy.
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The results of the treatment of 340 patients with malignant tumors in the laryngopharynx show the advantages of combined and surgical methods over radiation therapy: five-year survival after application of the above methods made up 43% and 12%, respectively. A new method of autovenous plastics of carotid artery is proposed to treat advanced metastatic tumors. Different variants of restoring pharyngeal integrity after the destructive operations are evaluated.