PubMed Health⌕ Search

Biomedical subjects

F R Weis

Publications and source records attributed to F R Weis.

14 recordsLinked to original sources
PubMed1990

Comparison of three techniques on time to awakening, time to orientation and incidence of nausea and vomiting using alfentanil in balanced anesthesia in an outpatient surgical setting.

Maximizing patient safety and comfort while minimizing adverse sequelae are continuing anesthetic challenges. The purpose of this study was to examine three anesthetic techniques utilizing alfentanil with regard to time to awakening, time to orientation and incidence of nausea and vomiting. Surgical procedures were limited to knee arthroscopy, laparoscopy and dental extractions. Unpremedicated ASA I/II outpatients (n = 74) between the ages of 18 and 59 were randomly assigned to one of three groups: Group I: alfentanil + 67% N2O + 33% O2 Group II: alfentanil + 67% N2O + 33% O2 + droperidol 0.015 mg/kg Group III: alfentanil + 100% O2 + 0.7% isoflurane Anesthesia was induced with alfentanil 40 micrograms/kg, atracurium 0.4 mg/kg, thiamylal 4 mg/kg and 100% O2 and was maintained according to group assignment. The anesthetic was supplemented as clinically indicated with incremental boluses of alfentanil 10 micrograms/kg. Upon completion of surgery, muscle relaxation was reversed with edrophonium 0.75 mg/kg and atropine 0.015 mg/kg. Analyses indicated that the three groups were comparable in terms of potentially confounding variables including gender, race, surgical procedure, age, percent of ideal body weight, case length and dose of alfentanil in micrograms/kg/hr. Time to awakening was significantly shorter in the two N2O groups by approximately 1.5 minutes, as compared to the O2 and isoflurane group (p = .0060). Time to orientation was significantly shorter in the N2O groups by approximately 1.5 minutes also, as compared to the O2 and isoflurane group (p = .0142). The two N2O groups did not differ significantly in either measure. The incidence of vomiting in the postanesthesia recovery room (PARR) indicated a significant difference (p = .0317) among groups with vomiting occurring 45.8% of the time in Group I, 28.8% of the time in Group II and 8% of the time in Group III. Total emetic score (nausea and vomiting) in the PARR indicated a significant difference (p = .03) among groups with symptoms occurring 50% of the time in Group I, 28% of the time in Group II, and 16% of the time in Group III.

Alfentanil↗
PubMed1989

Intubation by use of the light wand: experience in 253 patients.

Use of the light wand for 253 intubations in a variety of clinical settings is described. Twenty patients were successfully intubated by the light wand method who had failed to be intubated by direct laryngoscopy. Three failures were noted on patients who weighed more than 350 pounds each. Both nasal and oral endotracheal intubations were accomplished with minimal morbidity.

Humans↗
PubMed1985

Transient blindness following transurethral resection of the prostate in an achondroplastic dwarf.

Neurological complications associated with transurethral resection of the prostate have been reported in the past. We report on an achondroplastic dwarf who suffered transient blindness following transurethral resection of the prostate. The blindness correlated with a markedly elevated serum glycine level of 13,734 mumol. per l. We discuss the possibility of glycine being responsible for this complication.

Achondroplasia↗
PubMed1975

Cardiovascular effects of oxytocin.

Oxytocin, 5 to 10 units, is frequently given as a bolus injection following term delivery or elective termination of pregnancy. It is not general knowledge that this has any untoward effects. In the present study in young, healthy women undergoing elective termination of pregnancy, mean arterial blood pressure decreased approximately 30% and the total peripheral resistence 50%, 40 seconds after injection. However, heart rate increased 30% and stroke volume 25%, so that the cardiac output was elevated more than 50% above control. Oxytocin given as a dilute solution produced no circulatory change; hence, we suggest that this drug be administered in such fashion rather than by bolus injection.

Abortion, Induced↗
PubMedDate not supplied

Diffusion hyperoxia following preoxygenation.

Several minutes of 100 percent O2 breathing prior to inhalation induction with 79 percent N23 results in consistently higher PaO2 values during the first 10 minutes compared with prior air breathing. The theoretic maximum concentrating action of N2O uptake upon O2 is approximately the same (60 torr) regardless of gas breathed before induction.

Adult↗
PubMedDate not supplied

A randomized double-blind pilot study to compare conscious sedation produced by diazepam against sufentanil.

Intravenous sufentanil, an analog of fentanyl, was compared to diazepam for conscious sedation in ambulatory dental outpatients. Ten patients undergoing the surgical removal of impacted third molars served as subjects in a double-blind, within-subject, single crossover study. Sedation was achieved with a combination of 30% nitrous oxide/70% oxygen by nasal mask and either diazepam (0.05-0.15 mg/kg) or sufentanic (0.05-0.15 μg/kg) titrated to a clinical endpoint of altered speech and relaxation. Intraoperative physiologic monitoring, patients' and the oral surgeon's subjective estimates of efficacy and psychomotor recovery were used to compare the two treatments. Both patients (eight of 10) and surgeons (six of 10) preferred sufentanil sedation. No significant differences were noted between treatments for psychomotor recovery. These preliminary data in a small sample suggest that sufentanil produces adequate conscious sedation in dental outpatients and should be evaluated further with larger patient samples.

Adult↗