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Biomedical subjects

F Rabe

Publications and source records attributed to F Rabe.

At least 19 recordsLinked to original sources
PubMed2000

Hirudin determination in plasma can be strongly influenced by the prothrombin level.

Recombinant hirudin is increasingly used for therapeutic and prophylactic anticoagulation. Several laboratory methods are available to measure r-hirudin, including clot-based and amidolytic methods. The snake venom ecarin converts prothrombin to meizothrombin. Hirudin inhibits meizothrombin, causing a prolongation of the ecarin clotting time (ECT). Because the ECT depends on prothrombin levels in plasma, it was compared with a chromogenic substrate assay (CSA) for the determination of r-hirudin levels in prothrombin deficient plasma samples. R-hirudin (0.0-2.0 microg/mL) was added to plasma samples with decreasing prothrombin concentrations (100-0%). Using the ECT, false high r-hirudin levels were observed even in r-hirudin-free plasma, when prothrombin levels were below 50%. This effect was more pronounced with increasing r-hirudin levels. Additionally, r-hirudin (0.5 microg/mL) was added to plasma of patients with acquired prothrombin deficiency due to oral anticoagulation. Hirudin levels were also overestimated in these plasma samples using ECT. In plasma samples of patients treated with r-hirudin, because of suspected heparin-induced thrombocytopenia (HIT), hirudin levels were already measured falsely high, when the prothrombin levels were below 70%. The chromogenic substrate assay (CSA) determined correct values in all prothrombin-deficient plasma samples. Therefore, the CSA should be used for hirudin level determination, if overestimation due to prothrombin deficiency should be avoided.

Antithrombins↗
PubMed1997

Report of general temporary anticoagulation in the treatment of acute cerebral and retinal ischaemia.

BACKGROUND: Recurrent thrombo-embolism represents by far the commonest cause of cerebral and retinal ischaemia. In an open clinical study, experience with a largely general anticoagulation in the acute phase of cerebral and retinal ischaemia is reported. METHODS: From October 1993 to October 1996, 781 patients with acute cerebral ischaemia were admitted to the medical emergency ward. Taking contra-indications into consideration and after CT exclusion of cerebral haemorrhage (2%). Immediate therapeutic heparinisation (1.5-2-fold prolongation of aPTT) was administered to 664 patients (85%) over 7-10 days. In a concurrent Doppler/duplex comparative study, 143 patients with retinal artery occlusion were investigated for the prevalence of potential sources of emboli in the region of the extracranial carotids and internal carotid circulation respectively. 108 patients served as a reference group whose acute loss of vision of vascular origin could be attributed to retinal vein thrombosis. RESULTS: The complication rate of anticoagulation in acute cerebral ischaemia was 0.8% (major complications), and the recurrence rate during the period of treatment was 2.4%. In 131 patients with acute retinal ischaemia, therapeutic heparinisation was performed without ocular cerebral or extracerebral complications. Potential ipsilateral sources of emboli (highgrade carotid stenosis or complex plaques with thrombotic deposits) were found in 55%, but in only 7% of the control group (p < 0.0001). CONCLUSION: Immediate anticoagulation in the form of aPTT-monitored therapeutic heparinisation represents a rational and low-risk concept for the treatment of acute cerebral and retinal ischaemia.

Adult↗
PubMed1986

[Unilateral external ectopia of the male monoureter].

It is reported on the very rare clinical picture of a unilateral ectopy of the ureter in the male sex. Since about one third of all infantile malformations are of urological nature in the occurrence of a relapsing epididymitis/orchitis in childhood and adolescence, connected with the rectal palpation findings of a soft cell in the region of prostate gland and seminal vesicle which can be squeezed out, should be thought of such a clinical picture. An early recognition in good time prevents an atrophy of testicle and epididymitis or even their loss, connected with later infertility.

Adult↗
PubMed1985

Correlation between in vitro autoradiographic results and histological WHO grades in human urothelial bladder tumours.

253 biopsy specimens of 106 urinary bladder tumours have been examined by means of in vitro autoradiography and the results compared with the WHO grading. An increase of the average labelling index occurred parallel to increasing WHO grades. However, great inter-tumorous differences in proliferation behaviour existed particularly in papillary G2 and G3 urothelium carcinomas. Possible causes of this heterogeneity are discussed. In vitro autoradiography is a suitable method for the objective characterization of the malignancy potential of urinary bladder tumours.

Adenocarcinoma↗
PubMed1984

Percutaneous transhepatic drainage for malignant biliary obstruction.

Percutaneous transhepatic drainage ( PTHD ) is an adjunct in the management of malignant biliary obstruction. It can be used for two purposes: as a palliative measure alone or as part of the preoperative preparation. This study assesses the efficacy of this technique. The charts of all patients undergoing PTHD were reviewed, and the data were collated according to the intent of catheterization. In the palliative group (18 patients), bilirubin levels fell from 20 +/- 1.8 to 10 +/- 1.9 mg/dl. PTHD complications developed in 14 (78%), the 1-month mortality was 56 per cent (10/18), and all of the patients have died (mean, 2.3 months). In the preoperative group (17 patients), bilirubin levels fell from 17 +/- 1.4 to 6 +/- 0.6 mg/dl, PTHD complications developed in three (18%), and postoperative complications occurred in five (30%). All patients in the preoperative group survived operation, 11 of 16 dying a mean of 4.5 months postoperatively. The five surviving patients have lived 2 to 25 months. The authors conclude that PTHD significantly lowers the serum bilirubin in both preoperative and palliative groups. In the preoperative group, its use is associated with low morbidity and may improve the patient's preoperative condition. In the palliative group, PTHD is associated with an appreciable morbidity that tempers the enthusiasm for its routine use in this circumstance.

Aged↗
PubMed1984

[Clinical significance of urinary tract infection caused by Providencia stuartii].

Out of 75 patients in whom nosocomial infection of the urinary tract occurred following operation for disturbance of micturition 43 (57.3%) suffered clinically manifest inflammatory complications, however only in 26 cases (34.6%) was this germ the cause. In the remaining 17 cases there were superinfections. From these results it is concluded that the isolated Providencia stuartii strains were not very virulent. In cases of asymptomatic providencia-bacteriuria the authors consider specific antibacterial therapy to be indicated only if the excretion of germs does not cease spontaneously after micturition has been restored to normal.

Adult↗
PubMed1984

[Urothelial carcinoma of the bladder following cyclophosphamide therapy].

A report is given on a 73-year-old patient in whom a urothelial carcinoma of the urinary bladder developed 11 years after a cyclophosphamide therapy. Taking the international literature into account, possible developmental mechanisms are discussed. Patients who have undergone cyclophosphamide therapy should be subject to constant urological observation as a high-risk group.

Aged↗
PubMed1983

[Significance of radioisotope nephrography and sequential scintigraphy of the kidney for the indication of nephropexy in a hypermobile kidney].

In the present paper findings of radio-isotope nephrograms and sequential scintograms of the kidneys of 130 patients with mobile kidney are compared before and after nephropexy in order to show the value of the pathological findings for the indication of operative therapy. Flow impairment in vertical RNG, limitation of tubular secretion in RNG and activity depots and irregular distribution of activity in the parenchyma and system of cavities in NSC are of special importance for the indication of nephropexy. Both examinations are suitable for follow-up and for judging the success of nephropexy.

Female↗
PubMed1983

[Correlation of computer tomographic, kidney vasographic and histological study results in solid kidney tumors].

Computertomography evaluates renal expansion precisely. In 105 patients differential diagnosis by means of computertomography was 95% accurate. In 93% of the cases it agreed with renovasographic and histological findings. It was possible to demonstrate or exclude the intrusion of a tumour into the renal vein in 61% of cases of tumour of the left kidney and in 55% of growths on the right side. The computertomographic evaluation of the vena cava inferior was confirmed by the histological findings in 71% and 65% of the cases, respectively. It was possible to exclude lymphogenous metastasis in 89% of the cases. In 4% computertomography gave falsely positive findings. In so far as computertomographic examination can give an unambiguous evaluation of a renal growth and a certain proof or disproof of the intrusion of a tumour into the venous system is made, preoperative renovasography can be dispensed with. Information on the operability of the tumour should be supplemented by clarification of lymphogenous and distant metastasis.

Adolescent↗
PubMed1981

The teratogenicity of hydantoins and barbiturates in humans, with considerations on the etiology of malformations and cerebral disturbances in the children of epileptic parents.

A total of 194 children of epileptic mothers and 71 children of epileptic fathers were examined for mental retardation, neurologic disturbances, major malformations, and acrofacial dysmorphias typical for hydantoin-barbiturate embryopathy (HB-E). HB-E was observed in nearly 7% of the children of mothers on anticonvulsants during pregnancy. Barbiturates and/or primidone were observed to induce the same dysmorphic features as hydantoins. The teratogenic potential of hydantoins may be slightly increased in combination with barbiturates/primidone. Neither the 71 children of epileptic fathers nor the 46 children of epileptic mothers without anticonvulsants exhibited symptoms of HB-E. The frequency of major, unspecific malformations was increased in children of epileptic mothers as well as in children of epileptic fathers as compared with the general population. Cerebral disturbances without dysmorphias were increased in children of mothers with and without anticonvulsants, but this was rarely the case in children of epileptic fathers. Cerebral disturbances were observed more often in children of mothers with seizures during pregnancy than in children of mothers without seizures. Multifactorial genetic influences on major malformations and influences of maternal seizures on cerebral disturbances in the offspring are likely.

Abnormalities, Drug-Induced↗