PubMed Health⌕ Search

Biomedical subjects

F Rachel

Publications and source records attributed to F Rachel.

16 recordsLinked to original sources

[Subpopulations of T and B lymphocytes in venous peripheral blood and blood draining from lesions in patients with gastroduodenal ulcer, and gastric and colonic cancer].

In 30 patients with gastric and colonic cancer and 30 patients with gastroduodenal ulcer treated in a surgery department the absolute number and per cent of leucocytes, number of lymphocytes, active T-rosettes, B-cells, T-cells, populations of helper T-cells, suppressor T-cells, and T4/T8 ratio were determined in peripheral venous blood and venous blood draining the lesion. On the basis of these studies it was found that in patients with gastroduodenal ulcer and gastric and colonic cancer a decrease occurs of the number of immunocompetent cells, particularly of T-cells and helper T-cells. In patients with cancer a decrease was observed in the region of tumour particularly of the size of helper B and T-cells populations.

B-Lymphocytes↗

CEA and NCA levels in peripheral and tumour venous blood of patients with gastric and colonic carcinomas estimated by RIA and EIA methods.

Carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA) levels in draining tumour blood were compared with concentrations of these antigens in peripheral blood of patients with gastric and colonic malignancies. The controls were cases with gastric and duodenal ulcers. The results obtained by radioimmunoassay (RIA) were compared with enzyme immunoassay (EIA). It was shown that patients with high CEA levels in draining tumour blood also had elevated values of this antigen in peripheral blood, but that the CEA values in blood flowing from tumours were usually higher than in peripheral blood. CEA concentrations in tumour venous blood and in peripheral blood depended on clinical advancement and neoplastic venous invasion. NCA determination had no significance in clinical monitoring of studied neoplasms. CEA level determinations performed by the RIA using CEA standard prepared in our laboratory and assays with use of Abbott CEA-EIA kit gave fully comparable results.

Antigens, Neoplasm↗