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F Ramseier

Publications and source records attributed to F Ramseier.

8 recordsLinked to original sources
PubMed1998

A double-blind double-dummy study of citalopram comparing infusion versus oral administration.

BACKGROUND: This study compares antidepressant efficacy and tolerability of citalopram given either orally or as a slow drop infusion. METHODS: Citalopram (40 mg/day) was administered double-blindly as tablets or slow-drop infusion during the first 10 days and then open, orally, up to treatment Day 42. RESULTS: In 60 moderately to severely depressed patients, the Hamilton depression total score (17-items) at baseline was 23.9 and 23.6 in the active infusion (n = 30) and active tablet (n = 30) group, respectively. These scores dropped in both groups to 15.6 and 16.9 on Day 10, and to 10.3 and 10.2 on Day 42. Response rates (delta Hamilton > or = 50%) amounted to 33.3% and 17.9% on Day 10, and 66.2% and 63.3% on Day 42, without a relevant group difference in citalopram plasma concentration. CONCLUSION: Slow-drop infusion with citalopram shows a similar risk/benefit relationship to oral citalopram. The design of this study allowed us to evaluate pharmacological but not psychological factors which may contribute to response to slow-drop infusion.

Administration, Oral↗
PubMed1996

[Our knowledge is patchwork. Survey on the adherence to international guidelines concerning acute and long-term therapy in recurrent depressions and diseases in the schizophrenic field].

In order to assess the observance of international guidelines, 88 psychiatrists and 88 general practitioners (GPs) were asked about their pharmacotherapeutic concepts for depressive and schizophrenic patients with a questionnaire. 47% of the psychiatrists and 72% of the GPs returned their answers. 29% of the psychiatrists and 24% of the GPs treat their depressive patients after an acute episode for six months (in accordance with WHO consensus). 32% of the psychiatrists and 47% of the GPs would suggest prophylactic treatment after two or more depressive episodes as proposed by the WHO. After one or more episodes within the last five years 2.7% of the psychiatrists and 12% of the GPs would start prophylactic treatment as suggested by the WHO. 16% of the psychiatrists and 17% of the GPs would treat a schizophrenic patient after a first episode for 12 to 24 months as proposed by the International Consensus Conference. After two or more psychotic episodes, 16% of the psychiatrists and 31% of the GPs would treat their patients in accordance with international guidelines. The consensus of the WHO for the treatment of depression and the international guidelines for relapse prevention in schizophrenics are hardly known by the examining psychiatrists and GPs and rarely used as treatment guidelines.

Antidepressive Agents↗
PubMedDate not supplied

TSH, HGH, HPr, and cortisol response to TRH in depressed patients.

An intravenous (0.2 mg) and an oral (40 mg) TRH-test was performed on 21 depressed patients (4 psychogenous, 17 endogenous); TSH, HGH, HRr, Cortisol, T3, T4 and RT4 were measured. The test was redone after 3 weeks of antidepressive treatment. Using an oral stimulation, it looks like there would be a possibility to differentiate into different groups according to the severity of illness. It also seems that the oral stimulation is a possibility to get information on the beginning effectiveness of antidepressive treatment. The responsiveness to the oral stimulus returns earlier than the response to the i.v. stimulation. Roughly, one can also differentiate between endogenous and psychogenous depression with an oral TRH test.

Administration, Oral↗