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Biomedical subjects

F Rassoul

Publications and source records attributed to F Rassoul.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Postoperative behavior of parameters of intravascular lipid metabolism].

In order to investigate alterations of intravascular lipoprotein metabolism under postoperative conditions, clinical investigations and animal experiments with female Wistar rats were carried out. Total serum cholesterol, HDL-cholesterol and LDL-cholesterol are diminished in the postoperative state. In the immediate postoperative phase there is a rapid decrease of serum triglycerides. Post-heparin-lipolytic-activity is found initially enhanced whereas there is no change of triglyceride secretion rate. It is concluded that the decreased triglyceride level is the result of an elevated catabolism of triglyceride rich lipoproteins. Besides the fall of VLDL level the relative composition of VLDL changes. The quotients VLDL triglycerides/VLDL-phospholipids and VLDL-cholesterol/VLDL-phospholipids decrease under postoperative conditions.

Animals↗
PubMed1988

[Lipoprotein metabolism in patients with disordered thyroid gland function before and following therapy].

Clinical manifest hypothyreosis leads to changes of plasma lipoproteins, which are characterized by elevated LDL levels, an increase of the relation LDL cholesterol/HDL cholesterol, an elevation of the quotient cholesterol/triglycerides within the VLDL and an increase of the relation HDL2/HDL3. Both these changes and the diminished activities of post-heparin lipase of hepatic and extrahepatic origin are reversible after substitution therapy. On the contrary, patients with hyperthyreosis M. Basedow show low lipoprotein levels, high activities of post-heparin lipase and an elevation of the relation of the apolipoproteins apo C II/apo C III within the VLDL fraction.

Adult↗
PubMed1987

Carnitine and experimental carbohydrate-induced hyperlipoproteinemia.

Carnitine, beta-hydroxy-gamma-trimethylaminobutyrate, plays an important role as a factor necessary for the transport of long-chain fatty acids into the mitochondria. In order to investigate the influence of L(--)-carnitine on hyperlipoproteinemias, the experimental model of the sucrose-induced hypertriglyceridemia of the rat was used. In these experiments L(--)-carnitine in the dose of 11 mg per day and 100 g body weight was able to antagonize the sucrose-induced hypertriglyceridemia and the increase of serum-free fatty acid level in female rats of the Wistar strain. Carnitine administration did not change the activities of lipogenic liver enzymes and the activity of post-heparin lipase. On the other hand, carnitine administration increased the rate of fatty acid oxidation in the liver. The main result of the study, i.e. the lipid-lowering effect of L-carnitine, suggests the use of this compound in the therapy of hyperlipoproteinemias.

Animals↗
PubMed1986

[Lipoprotein metabolism in relation to age].

Ageing is associated with a variety of changes of intracellular and extracellular lipid metabolism. Depending upon age the the rapidity of synthesis and metabolism of lipids decreases and partly increased plasma lipoprotein levels are found. Both under basal and under special alimentary conditions the lipoprotein metabolism shows age-dependent changes which may lead to an increased risk for atherosclerosis. These results are important for therapeutic and prophylactic conditions.

Adipose Tissue↗
PubMed1985

The response of some intravascular and intracellular lipid parameters of the rat after treatment with isatin.

The effect of isatin on serum lipid concentrations, the activity of lipoprotein lipase, the activity of lipogenic enzymes and the oxidation rate of fatty acids of female Wistar rats were investigated. A decrease of the triglyceride concentrations could be observed after one week of treatment of the group of sucrose-rich alimented animals, after two weeks this was also the case with the group fed with standard food. There were no changes in the cholesterol concentrations. Post-heparin lipolytic activity was not influenced. The liver enzymes malic enzyme, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase showed a remarkable increase in activity. The simultaneous rise of the oxidation rate of 14C-palmitate in the liver was measured. On the basis of the present findings the accelerated degradation rate could be responsible for the hypolipemic effect of the substance. The possible participation of the carnitine shuttle in the lipid-lowering action is discussed on the basis of changed concentrations of total carnitine, free carnitine and acylcarnitine in pooled serum samples after treatment with isatin.

Animals↗
PubMed1982

[Adenosine deaminase activity in Hodgkin's disease (author's transl)].

The activity of adenosine deaminase (ADA) (EC3.5.4.4.) was determined in the blood plasma, erythrocytes, and lymphocytes of 23 patients with Hodgkin's disease and partly also in 99 control subjects. The enzyme activities were measured using adenosine as substrate and by analysis of ammonia. No correlation was found between the ADA activities in lymphocytes, erythrocytes, and blood plasma. The lymphocytes of the patients revealed lower ADA activities (U/g protein) than the lymphocytes of control subjects. The ADA activity is not reduced in plasma or erythrocytes. The lower activities of ADA in the lymphocytes of patients may be related to the impaired cell-mediated immunity of the Hodgkin's disease.

Adenosine Deaminase↗
PubMed1981

[Adenosine deaminase activity in leukemia patients].

The activities of adenosine deaminase (ADA) were measured in the blood plasma, erythrocytes, and lymphocytes of healthy reference persons and in patients affected with leukaemia. ADA is increased in patients with acute immature cell leukaemia, in patients with chronic lymphatic leukaemia it is comparatively low in lymphocytes. In chronic myeloic leukaemia ADA activities are different depending on the activity of the disease. ADA-activities in the blood plasma, erythrocytes, and lymphocytes do not correlate with each other. ADA-activities in leukaemias may be regarded as an indicator of increased purin metabolism rather a as parameter of disturbed cellular immunofunction.

Acute Disease↗
PubMed1981

[The age-dependent influence of diet on lipid metabolism (author's transl)].

In contrast to 3 months old rats of the Wistar strain show 18 months old animals an elevation of the serum triglyceride level under the conditions of a sucrose diet (25% of the energy uptake). Clinical investigations with women show a similar age difference. These results may not be explained by the age-dependent behavior of the activity of several lipogenic enzymes of liver and adipose tissue and of their adaptation to a sucrose diet, but the age-dependent decrease of the lipoprotein lipase activity may be of special importance.

Adolescent↗
PubMed1981

[Adaptation of lipogenic enzymes of liver and adipose tissue to starvation and refeeding (author's transl)].

The lipogenic enzymes-6-phosphate dehydrogenase, citrate cleavage enzyme and malic enzyme of both liver and adipose tissue of rate of the wistar strain show a diminished activity in dependence on age. In the liver exists no age difference of the characteristic adaptation under the conditions of starvation and refeeding, but in adipose tissue of 18 months old rats the lipogenic enzymes show a poorer elevation of activity during refeeding after a 48 h period of starvation than in 3 months old animals. The serum inulin level and his variation in starvation and refeeding are independent of age.

Adipose Tissue↗
PubMed1980

[Circadian rhythm and aging].

The circadian variation of several lipogenic enzymes of rat liver and of serum triglyceride and insulin levels was measured in dependence on age. In female rats of the Wistar strain subjected to a 12 hr light--12 hr darkness schedule malic enzyme and isocitrate dehydrogenase show a circadian cycle with maximum activities in the dark period, alpha-glycerophosphate dehydrogenase has a maximum at 14,00 hr. The circadian rhythm of these enzymes is synchronous in young and old animals, but the activities of malic enzyme and alpha-glycerophosphate dehydrogenase are lower in the liver of 18 months old rats in contrast to 3 months old animals at all time points. The activity of glucose-6-phosphate dehydrogenase of the liver of young rats increases during the light period and reaches a maximum at night. The enzyme in old animals does not show this circadian rhythm. There is no age-dependence of the circadian variation of serum triglyceride and insulin levels.

Aging↗
PubMed1980

[HDL/LDL-cholesterol, arteriosclerosis and age (author's transl)].

The level of HDL-Cholesterol of the serum of women decreases in dependence on age. Especially in the group of the 75-95 years old persons. The LDL-cholesterol shows an increase with a maximum in the age group 60-75 years. Thus the HDL/LDL-cholesterol quotient is reduced and the risk for atherosclerotic diseases is elevated. Serum HDL-cholesterol correlates positively with the post-heparin lipolytic activity of extrahepatic origin, but not with the hepatic lipase.

Aged↗
PubMed1980

[Intravasal lipoproteid metabolism and age (author's transl)].

The post-heparin-lipolytic activity of women decreases in dependence on age. This age dependence is the result of a diminished activity of post-heparin-lipase of extrahepatic origin, whereas no age differences of the activities of hepatic lipase exist. There is a negative correlation between serum triglycerides and the post-heparin-lipolytic activity, especially between the enzyme of extrahepatic source and the triglyceride level, but not between the hepatic lipase and triglycerides. Serum-HDL-cholesterol correlated positively with the post-hepatic-lipolytic activity.

Adolescent↗
PubMed1978

[Enzymes of carbohydrate and lipid metabolism in dependence on age (author's transl)].

The levels of the rat liver enzymes glucose-6-phosphate-dehydrogenase, alpha-glycerophosphate-dehydrogenase and citrate cleavage enzyme decrease between the age groups of 3 and 18 months. The half-life time of these enzymes is uneffected by age and the diminished levels of the enzymes in the liver of old rats can be ascribed to a reduced rate of enzyme synthesis. The half-life time of malic enzyme decreases as a function of age and this increased enzyme destruction may contribute to the diminished malic enzyme level of old rat liver.

ATP Citrate (pro-S)-Lyase↗