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Biomedical subjects

F Raudino

Publications and source records attributed to F Raudino.

At least 19 recordsLinked to original sources
PubMed2001

Non motor off in Parkinson's disease.

Besides the classic motor swings, many non motor fluctuations may occur in Parkinson's disease, but the clinical spectrum and the frequency of these symptoms are not well recognized. A total of 47 parkinsonian outpatients were questioned about any symptoms associated with off state. Nine patients had no fluctuations, 16 referred only to motor fluctuations and 22 to motor fluctuations associated with non motor symptoms. Overall, these patients referred to 54 symptoms (average 2.3/patients, range 1-6). These symptoms were classified as: autonomic (3 difficulty in swallowing, 7 hot, 11 sweat, 2 cold, 1 pallor, 1 abdominal bloating, 1 abdominal pain, 1 abdominal and genital pain, 5 bladder dysfunction, 2 feet oedema); sensory (7 sensory dyspnoea, 1 pain in lower limbs, 1 internal tremor); cognitive (3 depression, 4 anxiety, 2 panic, 1 drowsiness, 1 confusion). In patients without off periods, the length, severity and the average dosages of levodopa were fewer than in patients with fluctuations. No significant differences were found between patients with motor off and patients with associated non motor off regarding age (71.2+/-9.6 years vs 71.6+/-10.7 years), length of the disease (83.2+/-38.5 months vs 95.9+/-58.1 months), the Hoehn-Yahr (3.06+/-0.96 vs 3.02+/-0.96) and Webster (15.5+/-6.99 vs 15.1+/-5.9) scale, the dosages of levodopa (680.9+/-238.9 mg/die vs 679.7+/-289.6 mg/die), the number (2.3+/-1.7 vs 2.8+/-1.5) and length (6.8+/-5.2 h vs 7.2+/-7.1 h) of motor off. The non motor fluctuations were recognized in about 60% of patients with motor fluctuations: usually they were mild and less important than motor off, but sometimes these problems were disabling and led to unnecessary tests and therapies.

Aged↗
PubMed1997

F-wave: sample size and normative values.

F-waves were recorded from the abductor digiti minimi in 60 healthy subjects aged between 22 and 65 years. F-waves following 80 supramaximal stimuli were recorded. The F with minimal latency (Fmin), the mean latency (Fmean) and chronodispersion (CD) were calculated for each set of ten stimuli. In each subject the values after 10, 20, 30 etc. stimuli were compared with the "true" values obtained examining all responses. After twenty stimuli (16-20 F-waves) a Fmean with latency within 95% of the "true" value was recorded in the 95% of subjects. After twenty stimuli a Fmin with latency within 95% of the "true" latency was recorded in the 88% of subjects. Usually the Fmin after twenty stimuli is little different from the "true" Fmin (mean 1.4 ms), but in one subject the difference was 4.1 ms. The CD increases according to the number of responses examined and a careful evaluation requires 64-80 F-waves.

Adult↗
PubMed1997

Auditory event-related potentials in Parkinson's disease.

We studied 49 patients with Parkinson's disease (PD) by a neuropsychological battery examining the temporo-spatial orientation, short-term memory, comprehension, non-verbal intelligence, long-term memory and anomia and the Auditory Event-Related Potentials. In the patients the latencies of the N100 and N200 waves were prolonged and the amplitude of the P300 wave was reduced compared with controls. No difference was found in the ERP of patients with and without cognitive deficits. Equally, no correlation was found between the ERP, the cognitive impairment, the length or the severity of the disease evaluated by Hoehn-Yahr's and Webster's scales.

Aged↗
PubMed1994

Limb pain and headache.

The occurrence of limb pain in close temporal relationship with headache was sought in 245 (185 women and 60 men) patients. Eleven patients (4.4% three men and eight women) had referred pain at least once, in one or more limbs in close temporal relationship with headache. Usually the pain was located in the upper limbs, was concomitant with the headache but could precede or follow it. The severity and length varied between patients but was relatively stable in the same subject. It is possible that this symptom is more frequent than believed so far and that many patients are misdiagnosed.

Adolescent↗
PubMed1994

Is temporomandibular dysfunction a cranial dystonia? An electrophysiological study.

In 26 patients suffering from temporomandibular dysfunction (TMD) the silent period (ES), which consists of an early (ES1) and a late (ES2) inhibition which interrupts the voluntary electromyographic activity after an electrical stimulus, was recorded from the masseter muscles. Several different patterns were identified: in 8 patients (group I) the ES was normal; in 1 patient (group II) the ES was entirely absent; in 11 patients (group III) only the ES2 was absent and in 6 patients (group IV) ES1 and ES2 were combined. Such results can be explained by hypothesizing several functional states: normal excitability in group I, absolute (group II) or relative (group III) inexcitability and hyperexcitability in group IV. A central origin of TMD can be related either to a "dysregulation" of circuits located in the brainstem which give rise to the ES or to the centers, probably located in the basal ganglia, which control the circuits of the brainstem.

Adult↗
PubMed1990

The blink reflex in cluster headache.

To investigate the involvement of the trigeminal system in cluster headache, in twelve subjects the electrically-elicited blink reflex during a symptomatic period was examined. In eleven cases, the amplitude of the contralateral R2 response on the symptomatic side was significantly lower, at the same stimulus intensity, than on the asymptomatic side (p = 0.005). The blink reflex can be useful to evaluate biological and drug-induced phenomena in cluster headache.

Adult↗
PubMedDate not supplied

Tethered median nerve stress test in the diagnosis of carpal tunnel syndrome.

The sensitivity of the Median Nerve Stress Test (Stress Test) described by La Ban et al. and performed hyperextending for one minute the supinated wrist and the distal interphalangeal joint of the index finger and looking for pain in the proximal forearm was evaluated in 140 arms with Carpal Tunnel Syndrome confirmed electrophysiologically. The Stress Test was positive in 60 hands (42.8%), the Phalen's sign in 79 (56.4%) and the Tinel's sign in 59 (42.1%). Hypoaesthesia to pinprick in the distribution of the median nerve was found in 45 hands (32.1%) and weakness or hypotrophia of thenar eminence in 17 (12.1%). In spite of his low sensitivity, in some cases the Stress Test was the only clinical positive sign and, in addition to electrophysiological examination, may be helpful in clinical practice.

Adult↗
PubMedDate not supplied

Nerve refractory period in early polyneuropathies.

The refractory period of the sural nerve was evaluated in 115 patients with suspected polyneuropathy of various origin. They were asymptomatics or with minor, mainly sensitive, disturbances. In all the conventional neurophysiologic examination (motor and sensory velocities, distal latencies and F-waves of the peroneal, ulnar and sural nerves) was normal. The absolute refractory period (ARP) was defined as the shortest interstimulus interval at which a response to the second stimulus could be recorded. The relative refractory period (RRP) was defined as the interstimulus interval at which the responses to the first and to the second stimulus have equal latencies. The ARP was prolonged in 13 patients and the RRP in 28. In all, the refractory period was prolonged in 38 patients (33%). In any but three patients the ARP and the RRP were prolonged together. Thus the refractory period is more sensitive than the conventional neurophysiological examination in detecting early neuropathy. Moreover the ARP was modified in 2/9 patients with Steinert's myotonic dystrophy without clinical or electrophysiological signs of peripheral neuropathy.

Adult↗
PubMedDate not supplied

Fasciculations in peripheral neuropathies.

Among 115 subjects suffering from peripheral neuropathies of various origins, in 71 (61.7%) no fasciculations were noticed in the lower limbs, while they were present in 27 (23.4%); 17 (14.7%) reported the presence of fasciculations that, however, were not observed during the neurological examination or on EMG. The only difference between the subjects without and with fasciculations seems to be the greater number of polyphasic potentials registered at the EMG in the latter.

Electromyography↗
PubMedDate not supplied

[Late motor response: axon motor reflex and peripheral late wave].

The axon reflex (AR) is an intermediate response evoked by submaximal stimulation and eliminated by supramaximal stimulation: peripheral late wave (PWL) is a late motor response that appears with supramaximal stimulation and is regularly repeated. The PWL has been studied in 185 subjects and has been obtained in 70 cases (36 cases of polyneuropathies, 23 of nerve root lesions, 6 of peripheral nerve lesions, 1 of poliomyelitis and 4 healthy subjects); the AR has been studied in 35 subjects and found in 4 cases (2 cases of nerve root lesions, 1 of poliomyelitis and 1 of peripheral lesion). It seems that the two responses have no common characteristics and that the persistence of the PWL is rather inconstant.

Adolescent↗
PubMedDate not supplied

Electrophysiologic study of anomalous innervation of the intrinsic hand muscles.

With electrophysiological methods the possible presence of anomalous innervation and/or of anastomosis between the median and ulnar nerve in the intrinsic hand muscles was studied in 34 limbs. The abductor pollicis brevis was supplied by the ulnar nerve in 12% to 38%, the first dorsal interosseus by the median nerve in 4.2% to 19.6%; the abductor digiti minimi was in no case supplied by the median nerve.

Adult↗
PubMedDate not supplied

[Headache and response to intermittent photic stimulation].

It has been studied the answer to the LSI in migraine subjects (166) and with tension headache (198). Only in tree cases, which on migraine and two with tension headache, the answer given is anomalous to the LSI, with a frequency like those found in "normal" population.

Adolescent↗