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Biomedical subjects

F Raymond

Publications and source records attributed to F Raymond.

40 records · Page 3Linked to original sources

Self-concept of psychopaths.

The purpose of the present investigation was to study the self-concept of psychopaths. The sample consisted of 56 adult males: 28 psychopaths and 28 nonpsychopaths. The MMPI was used to select the sample. The Tennessee Self Concept Scale was administered to all Ss. The two groups differed significantly on 18 of the 28 scales used for the study. Sixteen of these differences were in the direction of greater deviance for psychopaths. Several inconsistencies were also observed in the self-concept of psychopaths. The results confirmed those previously obtained in other studies.

Adult↗

Dead space ventilation parallels changes in scintigraphic vascular obstruction at recurrence of pulmonary embolism and after thrombolytic therapy: a case report.

Physiological and alveolar dead space ventilation both increase in pulmonary embolism (PE) in proportion to the severity of vascular obstruction. The case of a patient with recurrent PE while on heparin therapy is presented. The recurrence was characterized clinically by severe pulmonary vascular obstruction and right heart dysfunction. The patient was treated with thrombolytic therapy, with excellent clinical and scintigraphic resolution. Dead space ventilation measurements at baseline, at the time of recurrence and after thrombolytic therapy are presented. The potential utility of dead space ventilation measurements for PE diagnosis and management are discussed.

Fibrinolytic Agents↗

[Pharmacokinetics of 3'-azido-3 deoxy-thymidine (AZT) in a patient undergoing hemodialysis].

Zidovudine (AZT) is the only effective drug in the treatment of AIDS. No data are available on the pharmacokinetics of this drug in patients with end-stage renal disease (ESRD). We report on the pharmacokinetics of zidovudine between sessions of hemodialysis and during the procedure in one patient with ESRD. In 1987 a 40-year-old man with ESRD treated with hemodialysis had the AIDS-related complex. The T4/T8 ratio was 0.49. An enzyme-linked immunosorbent assay and Western Blot studies revealed IgG antibodies specifically directed against HIV. The patient was then treated with zidovudine (100 mg three times daily). Studies of the pharmacokinetics of the drug, conducted between hemodialysis sessions, were performed on days 1 and 14 after the start of zidovudine treatment. Paired arterial and venous blood samples were obtained simultaneously one hour after the start of a hemodialysis session on day 20. The peak and the trough concentrations of zidovudine were 0.61 and 0.15 microgram per milliliter, respectively. We observed a marked accumulation of the main metabolite of zidovudine, G-AZT, with a concentration of about 65 micrograms per milliliter on day 14. The half-life was 2.9 hours. The hemodialysis clearance of zidovudine and its metabolite were 102 and 71 ml per minute, respectively. The half-life of zidovudine was three times longer in our patient than in a normal subject.(ABSTRACT TRUNCATED AT 250 WORDS)

Acquired Immunodeficiency Syndrome↗