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Biomedical subjects

F Regoli

Publications and source records attributed to F Regoli.

At least 19 recordsLinked to original sources
PubMed1994

Seasonal variation of trace metal concentrations in the digestive gland of the Mediterranean mussel Mytilus galloprovincialis: comparison between a polluted and a non-polluted site.

Seasonal changes in metal (Cu, Fe, Mn, Pb, and Zn) concentrations were observed in the digestive gland of the Mediterranean mussel, Mytilus galloprovincialis, from both a polluted and a non-polluted population. Digestive gland of mussels from the polluted site showed metal concentrations appreciably higher than in non-polluted organisms, especially for Pb (up to 160 micrograms/g d.w.), Mn (up to 300 micrograms/g d.w.), and Fe (up to 8,500 micrograms/g d.w.), whereas the two populations showed maximum mean values, respectively, of 34 and 20 micrograms/g d.w. for Cu and 170 and 120 micrograms/g d.w. for Zn. Over 1 year (1991), differences between maximum and minimum values were moderate only in the unpolluted organisms. During gametogenesis, while the metal concentrations (expressed as microgram/g dry weight) decreased in the digestive gland, the tissue burden (as microgram) in that organ remained nearly constant or increased slightly. The apparent decrease in metal concentrations was probably due to the penetration of gonadic tissues into the digestive gland during gametogenesis, which biologically diluted metal concentrations in mussels from both the polluted and unpolluted populations. The effect of mussel size on trace metal concentrations in the digestive gland was demonstrated during different stages of the reproductive cycle. Higher concentrations were found in smaller organisms; however, during the spawning period, due to the fact that this is not a synchronous process within a population, the organisms exhibit a high variability in digestive gland weight which can mask this relationship when digestive gland weight is used as a size-index and as a parameter of the trace metal digestive gland burden.

Animals↗
PubMed1994

Bioavailability of biologically detoxified lead: risks arising from consumption of polluted mussels.

The possible risk for human health arising from consumption of lead-polluted shellfish was suggested by experiments on the bioavailability for mice of a "biologically detoxified" form of the metal. In this work, young mice were fed with a mixed diet including mussels collected in a Pb-polluted area. Metal concentrations in blood, kidney, liver, urine, and feces and the activity of erythrocytic delta-aminolevulinic acid dehydratase were determined after 1, 2, and 4 weeks. Comparisons were made with mice treated with balanced diet, mixed diet including control mussels, and drinking water with lead dissolved as acetate. In mice fed polluted mussels, lead concentrations increased in blood, kidney, and liver, whereas no significant accumulation was observed in urine. Different responses in mice treated with Pb(CH3COO)2 in drinking water are probably due to the diversity of lead chemical form in the two treatments. Our results demonstrate the bioavailability of biologically detoxified lead that can be transferred to a consumer with possible consequences also for human health.

Animals↗
PubMed1981

[Dilazep vs. nifedipine in patients with stable effort angina. A double blind randomized study (author's transl)].

In a randomized double-blind study the activity of dilazep (D) vs. nifedipine (N) was evaluated in 50 outpatients with effort angina; 26 were treated with dilazep 300 mg/die and 24 with nifedipine 30 mg/die. The observation period lasted 30 days. Before and at the end of treatment were evaluated: ECG, basal and during hyperventilation test, ergometric test, BP, HR, DP, ST depression, arrhythmias, maximum tolerated and total work done, number of anginal attacks and side effects. In 19 symptomatic subjects (D), weekly anginal crises were reduced (p less than 0.001) with normalization of 6 patients (31.6%). In group N a reduction (p less than 0.001) of anginal crises/weeks was recorded with normalization in 3 subjects out of 14 symptomatic (21.4%). In both groups ST depression was significantly (p less than 0.001) reduced. ECG during exercise normalized in 9 patients (34.6%) of D group and in 5 (20.9%) of N group. Total work performed increased after treatment in both groups. 13 patients of group D complained 19 side effects, all of short duration, whereas 54.2% (13 subjects) of group N complained 25 side effects 13 of which (52%) of short duration and 12 (48%) persistent. The results obtained pointed out a superimposable therapeutic efficacy of the two drugs, but dilazep was better tolerated.

Aged↗
PubMed1981

[Exercise tolerance in angina patients 3 and 24 hours after administration of a new delayed-action preparation of metoprolol].

To assess the duration of improved exercise tolerance by metoprolol given in a new sustained-release formulation, 40 in-patients affected by stable exercise-induced angina pectoris received single-blind placebo in day 1 and thereafter, in double-blind cross-over once daily administration, metoprolol RETARD 100 mg and 200 mg in days 3 and 5. Symptom-limited cycloergometric exercise tests were performed at 3 and 24 hours after placebo and after each of the two doses of metoprolol RETARD. Duration of exercise, maximal workload and total work performed did significantly increase at 3 and 24 hours after metoprolol RETARD 100 mg (P less than 0.01) and 200 mg (P less than 0.01), without any significant difference between the two doses. Peak systolic arterial pressure and heart rate were lowered by metoprolol RETARD 200 mg at 3 (P less than 0.01) and 24 (P less than 0.01) hours, whereas only the peak heart rate at 3 hours was lowered (P less than 0.05) by the 100 mg dose. It is concluded that in patients with stable exercise-induced angina pectoris, metoprolol RETARD 200 mg appears to be able to increase exercise tolerance and to reduce exercise-induced myocardial oxygen consumption throughout 24 hours period. This may justify a once daily dosing schedule of the 200 mg dose, aimed at improving patient compliance.

Adult↗