PubMed Health⌕ Search

Biomedical subjects

F Reinoso Suárez

Publications and source records attributed to F Reinoso Suárez.

7 recordsLinked to original sources
PubMed2001

[A new history of basal ganglia and physiopathology of Parkinson's disease].

The author analyzes basic and clinical experimental works of the last forty years and reaches the following conclusions: The motor system is an indivisible entity in which the basal ganglia are a key part. An important link in the history of the basal ganglia is the description by Llamas and Reinoso-Suárez in 1965 of connections from the substantia nigra compacta to the globus pallidus medialis and lateralis, and striatum through extremely thin, diffusely distributed fibers. They also described connections from the ventral tegmental area to the basal forebrain and the cerebral cortex. These connections are still not accepted one decade later. Rather than as cortico-basal ganglia-cortical parallel loops, the basal ganglia are actually structured as a widely distributed neuronal network with a great biochemical and connective variety. Basal ganglia intrinsic circuits have an important influential role in this network. Very varied brain structures influence basal ganglia neuronal network, mainly the cerebral cortex and the thalamic nuclei, essentially those that receive output from the basal ganglia. This complex organization provides the foundations for and elucidates the difficulty of explaining the pathophysiology of the clinical manifestations of Parkinson's disease as well as illustrating the need for future multidisciplinary research on this topic.

Basal Ganglia↗
PubMed2000

[Cajal and neuroscience in the eve of the third millenium].

This is a brief history of the birth of Neuroscience as an independent branch of knowledge. The importance of Cajal's contribution to the structuralization of modern Neuroscience is described. Outstanding contributions to Neuroscience of the last century, particularly the Decade of the Brain, are summarized. The reason for the huge increase and interest in neuroscientific studies are given. Finally, I emphasize the challenge that multidisciplinary study and interinstitutional collaboration pose to advancing our knowledge of the human brain. The second part of the talk demonstrated the validity of Cajal's work in modern Neuroscience insisting on three aspects: 1) the microscopic study of the Mammalian central nervous system, 2) the neurogenesis and development of the nervous system and 3) the degeneration, regeneration and plasticity of the central nervous system. I conclude that Cajal's timeliness is reflected by the fact that there are few problems in modern Neuroscience which Cajal did not address at one time or other.

History, 19th Century↗
PubMed1999

[The neurobiology of slow-wave sleep].

In the two last years my lectures were addressed to the biological bases of wakefulness and REM sleep. The present lecture is focused on slow wave sleep, which corresponds to stages 3 and 4 in humans. These two sleep stages both present high voltage slow waves in the EEG that belong to the delta band (less than 3 Hz). Slow wave sleep usually lasts between 70 and 90 minutes in normal individuals, and takes place during the first hours of the night, as though our organism was making sure we got this essential sleep. Slow wave sleep is: a) the first sleep stage to recuperate after sleep deprivation, b) the stage with the most constant length even in individuals who have very different sleep habits, and c) the sleep stage that remains constant during experiments of gradual sleep reduction for eight-hour sleepers. This sleep stage is the one in which growth hormone is released and it essential for physical and intellectual efficiency and normal behavior in young adult individuals. Slow wave sleep is remarkably reduced in old people. What brain structures are responsible for the bioelectric and behavioral events of the slow waves sleep? Both the cerebral cortex and thalamus are indispensable for the existence of the slow waves EEG characteristic to this stage. Other brain structures participate in slow wave sleep organization; these include the basal forebrain, the oral pontine reticular nucleus, the deep cerebellar nuclei and the solitary tract nucleus. In this presentation I consider the most relevant functions of these structures as well as their anatomical connections, mainly with the neuronal networks responsible for other stages of the sleep-wakefulness cycle.

Adult↗