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Biomedical subjects

F Resch

Publications and source records attributed to F Resch.

26 records · Page 2Linked to original sources
PubMed1983

The TSH-response to TRH: A possible predictor of outcome to antidepressant and neuroleptic treatment.

This study was designed to investigate the possible common patterns of neuroendocrine mechanisms, which may be involved in the therapeutic effects of antidepressant drugs in depressive and of neuroleptic drugs in schizophrenic patients. Sixty-three depressed women (major depressive disorder) and 21 paranoid-hallucinatory women have been studied while on antidepressant (clomipramine) or neuroleptic (haloperidol) treatment, respectively. The neuroendocrine test (TRH-test) was performed at weekly intervals. The change of TSH-response to TRH during treatment, i.e. the treatment associated normalization of a former blunted TSH-response, can tentatively be regarded as a predictor of outcome for depressive and paranoid-hallucinatory patients to their respective drug treatments. Antidepressant and neuroleptic drugs appear to involve the normalization of the TSH-response in their therapeutic effects in that proportion of patients (40%) which showed a blunted TSH-response at admission.

Adolescent↗
PubMed1983

Mitral disc valve implantation in the dog: early and late valve thrombosis and its prevention.

Valve thrombosis and its prevention was studied in 33 Labrador retriever dogs who received Hall-Haster mitral disc valves during extracorporeal circulation with extreme hemodilution. Three antithrombotic regimes were used. (1) 12 dogs received 1 g heparin preoperatively, and Warfarin tablets from the first postoperative day. Anticoagulation was controlled with thrombotest (TT), aiming at 20-25% of normal coagulation activity. (2) 9 dogs received 10 mg of heparin intravenously hourly for 10 h, and intravenous injections of Warfarin daily, aiming at TT values of 15-20%. (3) The last 12 dogs had continuous heparin infusion for 24 h, and Warfarin injections before as well as after the operation in doses sufficient to reduce the TT to 10-15% of normal. Stable anticoagulation was very difficult to maintain. Only 15 dogs survived the first postoperative day, 7 were alive after 4 weeks. 7 early and 5 late deaths were due to valve thrombosis. All three antithrombotic regimes were equally ineffective in preventing thrombosis, and more intensive antithrombotic prophylaxis is needed to make the canine model suitable for experimental open-heart surgery.

Animals↗
PubMed1982

Estimation of flow in aortocoronary grafts with a pulsed ultrasound Doppler meter.

A newly developed pulsed ultrasound Doppler meter was used for measurement of blood flow in aortocoronary vein grafts during operation. The results were compared with measurements obtained with conventional electromagnetic flowmetry. In 27 grafts, excellent agreement was found between electromagnetic flow probes thoroughly calibrated for varying hematocrit on fresh veins in vitro, and a clip-on type of Doppler probe (r = 0.86). In vitro calibration showed a close correspondence (r = 0.98) with the Doppler technique with no dependency on hematocrit and no need for zero calibration. The use of a conventional electromagnetic flowmeter showed strong dependency on recent calibration, both for saline and for varying hematocrit. Zero-calibration was necessary for every single graft measurement. The application of ultrasound Doppler meters of high quality together with clip-on probes of proper design proved to be superior to electromagnetic flowmetry for intraoperative blood flow measurements.

Blood Flow Velocity↗
PubMed1982

Clinical and electrophysiological properties of a new temporary pacemaker lead after open-heart surgery.

A new temporary pacemaker lead, Medtronic 6400, with a solid defined electrode surface area of 7.5 mm2, has been implanted in 50 patients after open-heart surgery. One electrode was inserted intramyocardially on the right ventricle, while another was placed extracardially and served as a reference lead. Forty-six of the patients were followed postoperatively with measurements of myocardial stimulation threshold and resistance. In 25 of the patients, electrograms were recorded on magnetic tape for further computer analysis of amplitudes, slew rates, and signal source impedance. During constant current pacing, myocardial stimulation threshold increased from a median of 0.4 mA one hour postoperatively to a maximum value of 2.3 mA. In two patients (4.3%) intermittent pacing failure was seen. Stimulation resistance fell from a median of 875 omega to a minimum of 487 omega, with a subsequent increase of 598 omega before electrode removal. Both mean electrogram amplitude (7.35 mV) and slew rate (0.82 V/s) had their minimum values on the sixth postoperative day. Intermittent sensing failure was observed in 2/25 patients (8%). Signal source impedance was of a magnitude not likely to contribute to sensing failure. No complications were seen from the use of this lead. The new electrode is an important improvement in temporary pacemaker lead design.

Adult↗
PubMed1979

In vivo haemodynamic evaluation of the Hall-Kaster central flow prosthetic heart valve.

The first in vivo haemodynamic observations of the recently developed Hall-Kaster central flow prosthetic heart valve are reported. Haemodynamic evaluation of valve function was performed both in acute and chronic experiments following implantation of the Hall-Kaster prosthesis in the mitral position in dogs. These studies showed a low transvalvular pressure gradient, an effective opening angle of about 70 degrees and good diastolic flow through both the large and small orifices of the prosthesis. A slow rotational movement was depicted by the disc during opening and closure.

Animals↗
PubMed1972

Urethral rupture.

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Adolescent↗