Biomedical subjects

F Reymond

Publications and source records attributed to F Reymond.

23 records · Page 2Linked to original sources

PubMed1982

Evoked trigeminal nerve potential in chronic trichloroethylene intoxication.

Results of a study of trigeminal nerve impairment resulting from trichloroethylene intoxication by the somatosensory-evoked potential method reveal three kinds of abnormalities: increased stimulation voltage, excessive latency delay with morphological abnormalities, and excessive graph amplitude. These abnormalities confirm clinical disturbance (hypesthesia of the trigeminal nerve area) and open debate about the real mechanism of trichloroethylene neurotoxicity. Industrial intoxication by solvents, particularly trichloroethylene, is common. We have conducted a study of 188 workers chronically exposed to trichloroethylene and have confirmed the selective neurological disturbances of this intoxication in the trigeminal nerve (20%) [3, 10]. We utilized a new experimental method, developed for studies of chronic intoxications effecting the median nerve [5, 8], of recording the somatosensory evoked potential following stimulation of the trigeminal nerve [4, 6, 7]. The workers in this study were selected following clinical evaluation of their facial sensitivity and trigeminal nerve reflexes. In this paper we present our preliminary results on 11 workers, 9 suffering effects of intoxication and 2 controls.

Environmental Exposure↗

PubMedDate not supplied

Microchannel networks for electrophoretic separations.

UV excimer laser photoablation was used to micro-machine polymer substrates not only to drill microchannel structures but also to change the surface physical properties of the substrates. We first describe how UV laser photoablation can be used for the patterning of biomolecules on a polymer and discuss parameters such as surface coverage of active antibodies and equilibration time. Secondly, we show how to design a single-use capillary electrophoresis system comprising an on-chip injector, column and electrochemical detector. The potential of this disposable plastic device is discussed and briefly compared to classical systems. Finally, preliminary results on protein separation by isoelectric focusing on a disposable microchip are presented.

Adsorption↗

PubMedDate not supplied

[Reye's syndrome a clinical and electrophysiological study of four patients (author's transl)].

The authors studied four children with Reye's syndrome aged 16 months, 6 years, 8 years and 11 years respectively with severe liver failure and progressive coma. The laboratory investigations in all of them showed a marked elevation of serum transaminases, hyperammoniaemia and a prolongation of the prothrombin time. The electroencephalograms showed a grossly abnormal picture with generalised continuous delta activity. Three children survived with return to normal of the liver function tests whilst the fourth child died. In the last two patients an electroencephalogram carried out every six hours has enabled certain prognostic features to be determined. Improvement in the E.E.G. correlates closely with clinical improvement and vice versa. The authors also advocate serial E.E.G. recordings in Reye's syndrome. The role of hyperammonaemia in the genesis of encephalopathy and the electroencephalographic changed is discussed. The role played by raised intracranial pressure is stressed and the importance of controlling it in order to prevent further damage and improve the prognosis of this serious illness.

Amidinotransferases↗

PubMedDate not supplied

[EEG and clinical study of 107 patients with acute severe traumatic comas (author's transl)].

The authors describe the EEG recordings of 107 patients with acute severe cranial trauma and signs of axial lesions. The initial EEG included: sleep patterns, alternating tracings, alpha band tracings which were either nonreactive pseudo-alpha or modulated alpha often reactive, and diffuse slow wave tracings. They found no particular tracing corresponding to a precise level of rostrocaudal destructuration, but some associations were seen more frequently. EEG sleep patterns and alternating tracings were never observed in brain stem lesions, the activity recorded being of low voltage, rigid, and non-reactive. The presence of spontaneous fluctuations (with sleep rhythms in some cases) and reactivity in other levels (mesodiencephalic junction, diencephalic and cortical-subcortical) are good prognostic signs. Focalised EEG signs are seen especially in the more rostral levels.

Brain Injuries↗

PubMedDate not supplied

[Value of electromyography in the thoracic outlet syndrome (author's transl)].

Electromyogram studies were conducted in 55 patients with the thoracic outlet syndrome, together with the motor nerve conduction velocity (M.N.C.V) in the median cubital nerves, between the Erb's point and axilla and in the upper limb. Distal S.N.C.V. was measured in 19 cases. Proximal nerve compression was confirmed in 29% of cases, with associated carpal canal compression in 22%. The proximal N.C.V. of the median and cubital in the neurological forms, and of the median in the neurovascular forms, were significantly different from normal values in 18 control subjects, but were not so in the vascular forms. Through E.M.G. examination cannot confirm the need for surgery it can supply supportive evidence. No correlation between the clinical course and the proximal N.C.V. was found in the 18 patients seen after treatment (surgery in 13 cases).

Adolescent↗