[An uncommon cold: Lemierre syndrome].
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Acute Disease↗
Biomedical subjects
F Roblot
Publications and source records attributed to F Roblot.
Synthesis, spectroscopy, and cytotoxicity of glycosylated acetogenin derivatives as promising molecules for cancer therapy.
Several glycosyl derivatives of squamocin (1) have been synthesized by glycosylation under Lewis acid catalysis with two different 1-O-acetyl sugars. Separation of these compounds has been achieved by HPLC and centrifugal partition chromatography (CPC). A detailed NMR, ESIMS, and LSIMS study allowed complete structural elucidations. The cytotoxic activity of the glycosyl derivatives was investigated and compared with that of squamocin and dihydrosquamocin against human epidermoid carcinoma cells (KB), African green monkey (Cercopithecus aethiops) kidney epithelial cells (VERO), and mouse lymphocytic leukemia cells (L1210). The antiproliferative effects of some derivatives were studied on cell cycles in mouse lymphocytic leukemia cells (L1210).
Animals↗
Bisbenzylisoquinoline alkaloids from Guatteria boliviana (Annonaceae).
Together with known alkaloids, five new bisbenzylisoquinoline derivatives were isolated from the stem bark of Guatteria boliviana (Annonaceae), puertogalines-A 1 and -B 2, (+)-guatteboline 3, philogaline 4 and (-)-antioquine 5. Their structures were elucidated by spectrometric methods and their antiparasitic activity was evaluated in vitro on Leishmania sp., Trypanosoma cruzi and Plasmodium falciparum. Their cytotoxic activity was also measured in KB cell line.
Alkaloids↗
A new bistetrahydrofuran acetogenin from the roots of Annona salzmanii.
A new bistetrahydrofuran acetogenin, salzmanin (1), was isolated from the MeOH extract of Annona salzmanii, in addition to the known compounds, squamocin, almunequin, bullatalicin, and annonacin. The structure of 1 was elucidated by spectroscopic methods, including LSIMS-MS technique, and confirmed by a chemical transformation. The cytotoxic activity of 1 and squamocin was investigated.
4-Butyrolactone↗
[Mycotic aneurysm of the splenic artery. A rare complication of surgically treated infectious endocarditis and its causative cardiac lesion].
The authors report the case of a 59 year old woman with mitral valve streptococcal endocarditis complicating rheumatic valvular disease with several metastatic septic complications. In addition to ocular and cerebral localisations, the patient developed a very rare mycotic aneurysm of the splenic artery. Mitral valve replacement was necessary because of severe mitral regurgitation with major dilatation of the left heart chambers. This surgery was performed under high dose heparin therapy. Large aneurysms of the splenic artery carry a high risk of rupture. This splenic artery aneurysm was treated in the same operative session as the valvular disease by a sternolaparotomy: the aneurysm was operated first of all, and then valvular replacement was performed. Three years later, the patient is well and cured of the endocarditis. To the authors' knowledge, this is the third report of mycotic aneurysm of the splenic artery and the first case combined with surgery of the infectious valvular disease and the gastro-intestinal artery aneurysm.
Aneurysm, Infected↗
[Pneumococcal infections in the adult population observed at the Poitiers University Hospital. Epidemiologic and clinical study].
OBJECTIVES: The aim of this study was to assess the prevalence of penicillin-nonsusceptible pneumococcus (PNSP) infections and their clinical and microbiological features among an adult population hospitalized at the Poitiers University Hospital. PATIENTS AND METHODS: A prospective study was conducted between November 1994 and October 1995 and included all pneumococcus infections. RESULTS: Fifty-three adults with one pneumococcal strain were included. The overall rate of PNSP strains was 28%. Infections with PNSP strains were more resistant than penicillin-susceptible pneumococcus to other antibiotics. The most frequent infection was pneumonia (36 infections, 28% PNSP). DISCUSSION: The rate of PNSP in pneumococcal infections was the same in the Poitiers University Hospital as in national surveys in France. The high percentage of multiresistant strains (86.5%) limit the use of antibiotics other than beta-lactams. Surveys of pneumococcal resistance to antibiotics are needed to adapt antibiotic strategies to the local epidemiological situation.
Adult↗
[Down the claws!].
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Bartonella henselae↗
[Distinctive features of tuberculosis in the aged].
INTRODUCTION: Current recrudescence of human tuberculosis is ascribed to HIV. Nevertheless, other at-risk individuals, particularly the elderly, have been reported. METHODS: A retrospective study aimed at defining distinctive features of tuberculosis in the elderly was conducted. Eighty-two records of patients aged 18 to 64 years were compared to those of 58 patients of 65 years of age and over. RESULTS: In the French area considered in this study, the elderly represent the most at-risk group. Institutionalization is a significant risk factor for tuberculosis (RR = 4). Despite a past history of tuberculosis and public awareness campaigns, first-intent diagnosis was evoked in only 22% of the older patients. The mean number of infectious localizations was higher in the elderly (1.3/patient) than in younger patients (1.1/patient). Results of tuberculin skin tests are unreliable. Prognosis is poor in the elderly. In the present study, 14 of the 18 encountered deaths occurred in the elderly, of which eight were due to tuberculosis. CONCLUSION: To decrease the current incidence of tuberculosis, evaluations of preventive measures in the elderly should be validated and implemented, especially in institutionalized patients.
Adult↗
Three new bistetrahydrofuran acetogenins from the seeds of Annona spinescens.
Three new bistetrahydrofuran acetogenins, carolins A-C (1-3), were isolated from the MeOH extract of Annona spinescens in addition to the known compound, squamocin (4). The structures of 1, 2, and 3 were elucidated by spectroscopic methods including LSIMS/MS technique and confirmed by a chemical transformation, The cytotoxic activity of the new compounds 1-3 is reported and discussed in comparison with 4 and the previously isolated spinencin (5).
4-Butyrolactone↗
[Reduced penicillin-sensitivity pneumococcus arthritis and cellulitis. 2 uncommon sites].
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Arthritis, Infectious↗
[Community-acquired pneumonia of atypical presentation, role of macrolides].
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Adult↗
Lupus syndrome after parvovirus B19 infection.
Systemic lupus erythematosus is uncommon in elderly individuals. A 72-year-old woman developed parvovirus B19 infection followed by a systemic lupus erythematosus-like syndrome with persistent thrombocytopenia and Raynanud's phenomenon. Few cases of systemic lupus erythematosus after parvovirus B19 infection have been reported, and none had thrombocytopenia.
Aged↗
Coriadienin, the first annonaceous acetogenin with two double bonds isolated from Annona coriaceae.
A new Annonaceous acetogenin, coriadienin (1), has been isolated from the roots of Annona coriacea Mart. (Annonaceae). This structure is the first reported acetogenin containing two double bonds. Compound 1 showed potent cytotoxicity against VERO and KB cell lines. Compound 1 appears to play an important role in the biosynthetic pathway of mono- and bis-THF acetogenins, and it is proposed as a biogenetic precursor of coriacin. A known cytotoxic acetogenin, gigantetronenin, was also isolated from this plant.
Animals↗
New prenylated quinones from Peperomia galioides.
Two new prenylated quinones, piperogalone (1) and galopiperone (2), and a new prenylated dihydroquinone, hydropiperone (3), were isolated from Peperomia galioides H.B.K (Piperaceae). Hydropiperone exhibited potent antiparasitic activity against three species of Leishmania.
Animals↗
Pessoine and spinosine, two catecholic berbines from Annona spinescens.
The trunk bark and roots of Annona spinescens have been investigated for their alkaloid content. Two new berbine alkaloids, pessoine (1) and spinosine (2), have been isolated from the bark, and their structures were elucidated by spectroscopic methods. Eight known isoquinoline alkaloids were also obtained. The trypanocidal and antileishmanial activities of these isolated compounds have been investigated.
Animals↗
[Disseminated Mycobacterium bovis tuberculosis in an aged female patient without HIV infection].
The authors report the case of a woman affected by disseminated infection caused by Mycobacterium bovis, without risk exposure and immunodeficiency. There were chest and urinary localisations and bacteremia. Usually, M bovis is responsible of chest tuberculosis, in patients with professional exposure. Disseminated forms usually affect patients with immunodeficiency. Bacteria may be responsible of about 1% of tuberculosis, but real frequency is not known, because of its non specific report.
Aged↗
[Datura stramonium poisoning: the diagnosis is clinical, treatment is symptomatic].
Datura stramonium is a hallucinogenic plant found in urban or rural areas. It contains three main toxic alkaloids: atropine, scopolamine, and hyosciamine. Consumption of any part of the plant can result in severe anticholinergic toxicity. Clinical symptoms are those seen in atropine poisoning, particularly hallucinations and mydriasis. Prognostic is good in this study. Patients always require hospitalisation because of agitated behavior. Symptomatic treatment is efficient. Clinicians should be aware of the potential abuse of botanicals such as jimson weed to avoid excessive investigations.
Adolescent↗
Piperogalin, a new prenylated diphenol from Peperomia galioides.
A petroleum ether extract of Peperomia galoides showed significant in vitro activity against three Leishmania species and Trypanosoma cruzi. Three major prenylated diphenols, including two known compounds, grifolic acid [1], and grifolin [2], and the new substance piperogalin [3], have been isolated. Structures were established on the basis of spectral analysis including 2D nmr spectroscopy.
Animals↗