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F Roland

Publications and source records attributed to F Roland.

23 records · Page 2Linked to original sources
PubMedDate not supplied

[Effects of oral contraceptive preparations and smoking on lipoprotein repartition].

We studied the effect of oral contraceptives and smoking on the lipid profile of 251 women and 72 men, 20-29-year-old. In women, taking estroprogestatives, cholesterol, triglycerides, apoproteins AI and B were higher than in controls; HDL-cholesterol was not modified. Lipoprotein analyses in polyacrylamide gradient gel exhibited an increase of the HDL3 fraction at the expense of the HDL2 fraction, with a reduced LDL size. Smoking in addition to estroprogestative absorption accentuated these modifications and led to a decreased HDL-cholesterol (HDL2 fraction essentially), with an increased LDL-cholesterol. In men, smoking resulted in higher levels of total cholesterol, apoprotein B and LDL-cholesterol, without any significant change in LDL size, higher levels of triglycerides and lower level of the HDL2 fraction without any change in HDL-cholesterol. In women, smoking led only to an increase in triglycerides. In summary, analysis of the distribution of HDL subclasses and of LDL size showed an evolution towards a supposed more atherogenic lipid profile in women taking oral contraceptives associated or not with smoking, and in male smokers.

Adult↗
PubMedDate not supplied

Inhibition of Escherichia coli haemagglutination by phenothiazines.

The enterotoxigenic Escherichia coli strain H-10407 (078-H11) of Evans, possessing a colonization factor antigen (CFA/I) and haemagglutinating in the presence of mannose, was tested as to its ability to cause haemagglutination in the presence of phenothiazines. The phenothiazines (chlorpromazine, thioridazine, prochlorperazine, triethylpiperazine, promethiazine and promazine) were able to inhibit E. coli haemagglutination when added to the complex E. coli-erythrocytes. The most potent inhibitors were prochlorperazine and thioridazine, which inhibited E. coli haemagglutination in 1 min at a concentration of 1.5 mg/ml. The less potent was promethazine that inhibited haemagglutination at 6 mg/ml. Once haemagglutination had occurred the phenothiazines were able to reverse it, to "unhood" the E. coli from the erythrocytes. Prochlorperazine at a concentration of 0.4 mg/ml could reverse haemagglutination after 1 h contact with the E. coli erythrocytes complex. E. coli H-10407 grown in the presence of phenothiazines lost its haemagglutinating activity. The resulting non haemagglutinating E. coli recovered its haemagglutinating activity when recultured in a prochlorperazine free medium.

Chlorpromazine↗