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Biomedical subjects

F Roussel

Publications and source records attributed to F Roussel.

8 recordsLinked to original sources
PubMed1992

Euonymus europaeus lectin as an endothelial and epithelial marker in canine tissues.

The Euonymus europaeus agglutinin (EEA) is an endothelial marker in mammalia. In canine tissues, 4 types of endothelial cells (general, nervous, arterial, hepatic) were identified by the presence of the EEA receptor and by its sensitivity to neuraminidase enhancement. In adult dogs, EEA binding saccharides had endothelial or epithelial distributions and reactivities similar to those described for human tissues. Different EEA reactivities were observed between fetal, neonatal and adult canine tissues mainly at the arterial level. These findings suggest that the development of the binding sites is not identical in dog and man. Related lectins and monoclonal antibodies were used to characterize the EEA binding site, and the probable structure of the EEA binding saccharide in endothelial cells appeared to be alpha Gal (1,3) beta Gal (1,4) GlcNAc.

Animals↗
PubMed1991

A cytopathic effect of Trichomonas vaginalis probably mediated by a mannose/N-acetyl-glucosamine binding lectin.

The pathogenic effect of a highly pathogenic strain of Trichomonas vaginalis on McCoy cell monolayers was investigated. Specific inhibition of the cytopathic effect by monosaccharides, such as N-acetyl-glucosamine (GlcNAc) and mannose (Man), was observed. Our preliminary results suggest that the pathogenicity of T. vaginalis depends on a lectin specifically sensitive to GlcNAc and to a lesser extent to Man. Although N-acetyl-mannosamine was found to be the most efficient inhibitor, this effect seems to be unrelated to the natural biological behaviour of the infested host.

Acetylglucosamine↗
PubMed1979

[Tumor angiogenic activity (introductory note)].

Some classical experiments proving the existence of a Tumoral Angiogenic Factor are reproduced. They show the presence of T.A.F. in a solid tumor (Walker 256) and its apparent absence in a leukemia (L 1210). We point out that the biological activity oversteps the barrier of zoological class.

Angiogenesis Inducing Agents↗
PubMed1978

[Stages of carcinogenesis of experimental colonic tumors induced with 1-2 dimethylhydrazine].

The authors poisoned 500 female Wistar rats with a dialy dose of 15 mg/kg, The total dose ranged from 15 mg/kg to 420 mg/kg, according to the group. The animals were either killed when the dose defined for each group and been reached, or allowed to live. In a first series of 6 groups (120 animals), the following facts were noted: tumours deeveloped in all animals left alive, after 28 weeks (total dose of 1/2 D.M.H. = 420 MG/KG). Changes in the mucosa were seen from the 40th day on with, in the descending colon, a punctate abnormality involving two or three glandular tubes, in general at the summit of the folds. This abnormality consisted of basophilia of the upper part of the tubes, with a loss of mucus secretion. All transitional stages were seen between this lesion, hyperplasia of the apex of the tubes, the formation of "polyp seeds" and the appearance of polyps. Carcinomas most frequently developed in polyps but sometimes in flat mucosa. In the ascending colon, changes in mucosecretion were seen after a similar time delay at the base of the glandular crypts.

Animals↗
PubMedDate not supplied

Identification of human papillomavirus antigen in a bladder tumor.

Human papillomavirus (HPV) antigen was found in one of six noninfiltrating (grade II) carcinomas of the bladder. The antigen was located in the nuclei of the superficial cells. This virus-bearing tumor occurred in a patient with no known risk factors. The presence of HPV in low-grade urinary lesions seems to be frequent and may reflect the early stages of carcinogenesis; in fact, HPV infections may cause papillomas and carcinomas of the urothelial mucosae as well as the genital mucosae.

Antigens, Viral↗
PubMedDate not supplied

Fine needle aspiration of retroperitoneal human dirofilariasis with a pseudotumoral presentation.

The accidental finding of a pseudotumoral para-aortic mass in a 60-year-old woman led to the performance of a fine needle aspiration (FNA) biopsy under ultrasonographic guidance. The milky aspirate was centrifuged and processed as a cell block. The examination of sections confirmed the lymphatic origin of the sample, but also revealed some unexpected parasitic structures. While a complete identification could not be made on a few sections, the morphologic and epidemiologic evidence suggested Dirofilaria repens. The mass was surgically removed and identified as an adenolymphocele, which appears to be a new localization of dirofilariasis in humans. This case emphasizes the utility of FNA in diagnosing such unexpected findings without the use for exploratory surgery.

Animals↗