[Measures for critical support at the pre- and post-transplantation stage].
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Biomedical subjects
Publications and source records attributed to F Ruza.
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We report 31 episodes of hypertensive crises in children, managed with sublingual nifedipine at the following dosages: 10 mg in children with body weight (BW) higher than 20 kg, 5 mg in children with BW between 10 and 20 kg, and 2.5 mg in children with BW below 10 kg. The mean initial blood pressures were 161.41 mm Hg for the systolic pressure (mSBP) and 111.25 mm Hg for the diastolic pressure (mDBP). After nifedipine, both the mSBP and the mDBP decreased, with onset of effect five minutes after dosage and maximum decrease at 60 min (mSBP 134.93 mm Hg, mDBP 79.23 mm Hg, for decreases of 16.4 and 28.7%, respectively), and this effect persisted for 180 min. Blood pressure increased again from min 240 to min 360, yet without reaching the initial levels. One case did not respond to the first dose of nifedipine and required a second one. The effect of nifedipine was more pronounced on the DBP than on the SBP, and greater reductions of both pressures were achieved in the cases with higher initial readings. No side of medication were observed in our patients.
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Three cases (one, newborn infant and two infants--one of them recently published--) who present electrocardiographic and enzymatic alterations comparative with diagnosis of ischemia and myocardial infarction are reported. Rarity of this entity in infants is stressed as most of published cases are secondary to ananomolous coronary artery. Etiology of the cases presented shows a myocardiac fibrosis with Schwachman's syndrome in one case, a coronary thrombosis secondary to a disseminated intravascular coagulation in a second case, and finally a generalized hypoplasia of coronary arteries. Hypoxia appears in these cases a factor acting in favour of myocardial ischemia. Diagnostic criteria of acute myocardial infarction are based on typical electrocardiogram and rise of isoenzymes of LDH and CPK-MB. Although rare, it is a diagnosis to be considered in cases of unknow cardiac insufficiency in newborns and infants.
Because of the absence of enough data in the literature of normal values of differential temperature in the pediatric age, authors have registred rectal temperature and peripheral temperature on the tip of the great toe with the use of a thermistor as well as differential temperatures between both of them in 100 children which were divided in four groups depending upon the ages. All of these children had clinical evidence of normovolemia. All the tempertaure recordings were done under constant temperature and constant environmental humidity. The following data were found: Group I (newborn infants between 1-30 days): delta T = 6.08 degrees C; +/- 1.74 SD. Group II (infants between 1-12 months); delta T = 5.91 degrees C; +/- 2.0350 SD. Group III (children between 1-3 years): delta T = 5.39 degrees C; +/- 2.14 SD. Group IV (children between 3-8 years): delta T = 4.78 degrees C; +/- 2.14 SD. Difference between central and peripheral temperatures recorded at constant environmental temperature and humidity is an early and sensible measure of peripheral perfussion degree and is an easy economical and non-aggressive method of monitoring shock syndrome in children.
Physiopathology of hypertonic dehydration is revised. The bases of treatment are discussed; they are based on: 1. Basal requirements of fluids. 2. Slow correction of deficit. 3. Replacement of maintaining losses. Total fluids support will carry to rehydration in 2 or 3 days. In the most severe cases peritoneal dialysis is associated. The indications, technique and realization of peritoneal dialysis during hypertonic dehydration are discussed.
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A revision of the ethiology in hypertonic dehydration of 80 infants admitted in the Clínica Infantil "La Paz", between 1972--1973 is made. The most important ethiological factors were: hyperconcentrated food (86% in neonates), vomiting, diarrhoea, increase of insensible water loss (respiratory, fever). The etiopathogenic and physiopathologic bases of hyperconcentrated diet in the development of hypertonic dehydration in accordance with "solute overload" to neonatal kidney are discussed. The autoperpetuation mechanisms of hypertonic dehydration are also discussed.
Authors analyse incidence of age, sex and weight in a group of 80 infants with severe hypertonic dehydration. The highest frequency occurs in the first month of life (50%). They study the clinical manifestations of dehydration, neurological condition, diuresis, escleremia, other pathology, complications and mortality. Causes of death are detailed. Peculiar clinical manifestations are discussed according to different ages, emphasising importance of E.C. component in the first weeks of life. Efficiency of peritoneal dialysis is evaluated.
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Authors analyse treatment and clinical and analytical evolution of 80 patients with hypertonic dehydration, depending on shock and acidosis. Several considerations concerning treatment and its' influence on evolution of different patients, emphasizing both therapeutic methods: with or without use of peritoneal dialysis, according to the values of initial natraemia, are made.