Biomedical subjects
F S Barar
Publications and source records attributed to F S Barar.
Synthesis and pharmacological evaluation of triazolo derivatives of 8-amino-10,11-dihydro-dibenzo[b,e]1,4-thiazepine-11-one.
In the present communication, the syntheses, characterization and pharmacological evaluation of 8-amino-(1,2,4)-triazolo[4,3-d][b,e]1,4-dibenzothiazepine (4) and its various substituted analogs (6-9) are reported.
Isoprenaline-induced myocardial damage & the cardioprotective action of some beta-adrenoceptor blockers in albino rats.
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Brain acetylcholine content in experimentally induced aggression in mice & its modification by testosterone, diethylstilbestrol & norgestrel.
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Tremorine-oxotremorine-induced tremor, hypothermia and analgesia, and physostigmine toxicity, in mice after pretreatment with beta-adrenoceptor antagonists.
The beta-adrenoceptor blockers propranolol, PhQA33 and LB-46 exhibited appreciable activity against tremorine-(TMN) and oxotremorine-(OTMN) induced tremor, whereas pronethalol, (+)-H56/28, (-)-H56/28, Kö-592 and L(+)-INPEA possessed weak action. The two beta-blockers, namely D,L(+/-)-INPEA and D(-)-INPEA acted as weak tremorgens. None of the above compounds suppressed the induced peripheral cholinergic phenomena; or possessed any central anticholinergic activity, as they were unable to afford protection against physostigmine-induced death. Propranolol, PhQA33 and LB-46 antagonized TMN-induced hypothermia and analgesia, but were inactive against OTMN-induced changes. A correlation of the beta-blocking and anti-tremor activity of these agents is unlikely.
Effect of beta-adrenoceptor blocking agents on isolation and apomorphine-induced aggression in rodents.
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