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Biomedical subjects

F S Freiha

Publications and source records attributed to F S Freiha.

At least 91 records · Page 5Linked to original sources
PubMed1984

Prognostic significance of a decline in serum human chorionic gonadotropin levels after initial chemotherapy for advanced germ-cell carcinoma.

We studied 40 consecutive patients with advanced germ-cell carcinoma and elevated serum levels of human chorionic gonadotropin (HCG) to assess the prognostic value of the magnitude of the decline in HCG levels after chemotherapy. If serum levels failed to become normal after the first chemotherapy cycle and if the day-22 HCG level/day-1 level was greater than 1/200 (0.005), an incomplete response to chemotherapy could be predicted with a sensitivity of 90% and a predictive value of 94%. Conversely, if the day-22 level was within normal limits, or if the day-22 level/day-1 level was less than 1/200, a successful response to chemotherapy (defined as a 1-year disease-free interval following cessation of chemotherapy) could be predicted with a sensitivity of 95% and a predictive value of 91% after one chemotherapy cycle. Overall, the long-term response to chemotherapy was correctly predicted in 37 of 40 patients (p less than 0.0001, compared with actual patient outcome using the chi-squared test).

Adult↗
PubMed1983

Salvage cystectomy.

This report presents the results of 40 salvage cystectomies performed after failure of radiation therapy to control the disease in patients with bladder cancer. All patients had failure or recurrence after 7,000 rad. The time between end of radiation therapy and cystectomy was three to six months in 11 patients, seven to twelve months in 15, thirteen to twenty-four months in 8, and longer than thirty-six months in 6. There were two immediate and four late postoperative deaths. A total of twenty-two complications occurred in 16 patients. The five-year survival rate was 100 per cent for patients with in situ carcinoma, 58 per cent for Stage A disease, 50 per cent for Stage B1, and 40 per cent for Stage B2 disease. There were no survivors among patients with Stages C and D1 disease. Salvage cystectomy, although associated with significant morbidity, remains a viable form of therapy for patients in whom definitive radiotherapy fails.

Carcinoma in Situ↗
PubMed1983

Weekly doxorubicin in endocrine-refractory carcinoma of the prostate.

Twenty-five patients with endocrine-refractory prostatic carcinoma were treated with doxorubicin, 20 mg/m2 given weekly. All patients had prior hormonal therapy (68% had two or more prior hormonal maneuvers), and 21 (84%) had prior therapeutic or palliative irradiation. Median Karnofsky performance status at the time of entry was 70. Hemoglobin was less than 12.0 g/dL in 15 patients. Bidimensional tumors were present in 12 patients in 19 disease sites; four of the 12 patients (33%) responded in eight of the 19 sites (42%); and three of eight patients had a 75% decrease in prostatic nodule size. Ten of 20 evaluable patients had an improvement of 20% or greater in Karnofsky performance status and 67% (14 of 21) had marked improvement in pain. A greater than 50% reduction or normalization of acid phosphatase occurred in 19% and of alkaline phosphatase in 53%. The overall response rate by National Prostatic Cancer Project criteria was 84%. Gastrointestinal toxicity and alopecia were minimal and myelosuppression was not life threatening in any patient.

Aged↗
PubMed1981

Primary neoplasm in vesical diverticula. A report of 12 cases.

Twelve patients with primary carcinoma arising in a vesical diverticulum are presented. Treatment included diverticulectomy with or without post-operative irradiation and transurethral resection. Recurrences were detected in 6 patients and the disease-free survival rate was 8%.

Adult↗
PubMed1980

Complications of cystectomy.

Analysis of 50 consecutive cystectomies performed by 1 surgeon during a 3-year period is conducted to determine the rate of complications (32 per cent) and the operative mortality (2 per cent). Rectal injury during salvage cystectomy represents the most major complication and wound infection was the most common complication.

Humans↗
PubMed1980

The surgical treatment of intractable interstitial cystitis.

Nineteen patients with severe intractable interstitial cystitis were treated surgically with either cecocystoplasty, urinary diversion with or without cystectomy, cystolysis or segmental bladder resection. Of the 6 patients who underwent an augmentation cecocystoplasty 4 were cured and 2 ultimately had urinary diversion before cure. Of the 7 patients who underwent urinary diversion with or without total cystectomy 6 were cured. In the cystolysis group the suprapubic pain was relieved either totally or partially in all 5 cases, and nocturia and urinary frequency were reduced substantially in each. However, only 1 patient was cured completely of all symptoms. The patient who underwent segmental resection of the bladder experienced only temporary symptomatic relief. Postoperative complications included pyocystis in 2 patients who had urinary diversion without cystectomy and hydroureteronephrosis in 1 patient after ureterosigmoidostomy that required multiple procedures. The place for each of these major surgical procedures in the treatment of intractable interstitial cystitis is discussed.

Adult↗
PubMed1979

Evaluation of partial cystectomy for carcinoma of bladder.

We reviewed 117 patients who had undergone partial cystectomy for primary carcinoma of the bladder. The recurrence rate was 78 per cent. Treatment of recurrences included transurethral resection, radiation therapy, and total cystectomy. The five-year survival rate of patients treated for recurrent disease was 68 per cent for Stages 0 and A, 31 percent for Stage B, and 6 per cent for Stages C and D1. Total cystectomy gave the best salvage rate. The five-year survival rate of patients without recurrences was 4 per cent.

Adult↗
PubMed1979

Complication of Clorpactin WCS90 therapy for interstitial cystitis.

A case of ureteral fibrosis complicating Clorpactin WCS90 treatment for interstitial cystitis in a patient with vesicoureteral reflux is presented. The results of a laboratory experiment designed to study the effects of Clorpactin WCS90 on refluxing ureters are discussed.

Animals↗
PubMed1979

Pelvic lymphadenectomy for staging prostatic carcinoma: is it always necessary?

There were 100 patients with clinically localized prostatic carcinoma staged surgically for the evaluation of lymph node metastases. By correlating the incidence of lymph node metastasis with the level of serum acid phosphatase, and the stage and grade of the primary tumor, it was possible to identify 1 group of patients with less than 8 per cent incidence of lymph node metastases and another group with more than 92 per cent incidence of nodal involvement. It is in these 2 groups of patients that pelvic lymphadenectomy for the staging of prostatic carcinoma may not be necessary.

Acid Phosphatase↗
PubMed1977

Preoperative bowel preparation in urologic surgery.

A method is described for the preparation of patients undergoing urologic procedures in which a segment of bowel is to be used to reconstruct the urinary tract. The combination of mechanical and antimicrobial preparation is effective in the sterilization of the bowel and the prevention of wound sepsis.

Anti-Bacterial Agents↗