Biomedical subjects
Publications and source records attributed to F S Haddad.
A case of penile metastases secondary to transitional cell carcinoma of the bladder is reported. The patient was treated with chemotherapy and had the longest survival ever reported for this condition: 20 months; this compares favorably with the 4-month average survival of patients treated by surgery and/or radiotherapy.
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Two cases of extradural spinal angiolipomas are reported. The literature is reviewed and the entity of extradural spinal angiolipoma proposed. A tumor of adulthood, unassociated with bony changes, it occurs mainly in the mid-dorsal spine. Paraparesis progresses over a period of 1-2 years and may wax and wane with pregnancy or body weight changes. Characteristically, the tumor lies over the dorsal aspect of the dura, from which it may be peeled off easily. Its port-wine color contrasts strikingly with the contiguous epidural fat. A benign condition, it responds favorably to surgical excision.
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Although Wilms tumor has been a favored subject for cytogenetic investigation, little is known about chromosomes in adult urinary tract cancers. For this reason, we excluded Wilms' tumor and studied a series of 32 adult urinary tract tumors. Nineteen tumors had detectable autosomal abnormalities. Each of ten renal tumors (consisting of eight renal cell and two transitional cell carcinomas) had three or more chromosome abnormalities. Two candidates for primary chromosome changes in renal cancer are rearrangement of 3p14 and an unbalanced translocation with breakpoints of 5q13 and 14q22. Trisomy 20 is a frequent secondary change. Other nonrandom changes in renal cancer are rearrangements of 1q and +7, -8, -9, -14, -15, +16, and deletions of 17p. Eight bladder and a ureter tumor were all transitional cell carcinomas. Two bladder and the ureter tumor had only one detectable abnormality: deletions of 10q24 and 21q22 and +7, respectively. Other nonrandom bladder changes were -9, +13, +15, and +20. From a cytogenetic standpoint, adult urinary tract tumors appear to be chromosomally complex but critical consistencies are emerging.
Nine cases of lower tract urolithiasis after prostatectomy are reported. In addition to these 9 cases 223 from the world literature and 10 from our previous experience also are reviewed. Stones may form after prostatectomy in various locations of the lower urinary tract, including the bladder, bladder diverticulum, prostatic fossa, simultaneously in the bladder and prostatic fossa, and, occasionally, in an iatrogenic pouch. They occur after all forms of prostatectomy, that is surgical or endoscopic, and after benign as well as malignant prostatic lesions. Calculi that form in the bladder most frequently are the result of stasis owing to bladder neck contracture or recurrence of prostatic enlargement. Calculi that form in the prostatic bed (or fossa) are caused by a ligature, infection or a chip of prostate left behind in the prostatic bed. Diagnosis is sometimes difficult because these stones are not always radiopaque and they are not always seen on endoscopy. The interesting theoretical considerations concerning the etiology of these calculi and the measures that could be helpful in their prevention, such as meticulous postoperative care, are discussed.
Twenty cases of silica stones (including a personal one, the first case ever observed--April 1952) are reviewed. Almost all of the patients had been taking magnesium trisilicate for several years, one up to 40 years. The average age of the patients was 54 years. There were 9 males and 1 female. The patients came from the following locations, given in chronological order: Beirut, Lebanon (1952); Stockholm, Sweden (1953, 1962); Houston, Tex., USA (1958, 1961); New York, N.Y., USA (1960); Johannesburg, South Africa (1964); London, UK (1973, 1982); Osaka, Japan (1978); Madrid, Spain (1978, 1981); and Torrance, Calif., USA (1984). 14 patients passed out the stones spontaneously. In 3 patients, the stone was formed in the left kidney. Bilateral renal stones were found in 2 patients. In 2 patients, they were removed from the left ureter and in 2 patients they were found in the bladder. The size of the stones varied between 2 mm and 3 cm, the weight from 8 mg to 3.6 g. The silica stone is of a relatively low radio density. Our case is the only one in whom the level of urinary silica was determined; it was of the order of 0.006% i.e. 1 mmol/l.
73 cases of penile metastatic tumors secondary to prostatic cancer have been collected from the literature (including a personal case) and have been thoroughly reviewed.
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This is a case report of transitional cell carcinoma of the bladder which metastasized to lymph nodes, bone, and the penis. The penile metastases were demonstrated by cavernosography. Secondary tumors in the penis are rare. They presage a bad prognosis and a rapid demise; the patients survive an average of four months.
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Two identical twins contracted measles simultaneously in the same house at the age of six months. Only one member developed subacute sclerosing panencephalitis (SSPE) at the age of ten years. The other member remained healthy until after two years of follow-up. This case emphasizes the importance of factors other than host-measles virus interaction in the pathogenesis of SSPE.
73 cases of penile metastatic tumors secondary to bladder cancer have been collected from the literature. The cases are reviewed in regard to incidence, geographical distribution, age, interval between diagnosis of bladder cancer and appearance of penile metastases, symptoms, physical examination, endoscopy, diagnosis, differential diagnosis, routes of metastases, pathology, treatment, and prognosis. The spread of the tumor in and along prostatic nerves is documented.
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