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Biomedical subjects

F Saborowski

Publications and source records attributed to F Saborowski.

At least 37 records · Page 2Linked to original sources
PubMed1984

Investigations on staphylococcal infection of transvenous endocardial pacemaker electrodes.

Infections of pacemaker electrodes and/or aggregate pockets are usually caused by staphylococci, primarily Staphylococcus epidermidis. From in vitro experiments it can be demonstrated that staphylococci are able to adhere to the plastic electrode sheath, to multiply there, and to form microcolonies. Furthermore, the staphylococci produce a slimy amorphous substance with which they are completely covered after a 24-hour incubation. No difference was noticed between the in vitro experiment situation and that occurring in pacemaker infection in humans. This slimy material may be responsible for the maintenance of the infection and the protection of the enclosed bacterial cells against natural host defense mechanisms and antibiotic treatment.

Aged↗
PubMed1984

Effect of haemodynamic changes during rapid atrial pacing on determination of sinus node recovery time.

Arterial blood pressure was continuously monitored during rapid atrial pacing in 31 patients with different types of heart disease to determine sinus node recovery time and corrected sinus node recovery time. Pacing was initiated at 70 beats/min and increased stepwise to 160 beats/min. One to one atrioventricular conduction was maintained throughout the one minute stimulation period. Blood pressure fell initially during at least one stimulation period in 21 of our patients and at pacing rates up to 130 beats/min in 18. Once blood pressure had fallen during overdrive pacing maximal sinus node recovery time and maximal corrected sinus node recovery time could not be prolonged by increasing the pacing rate. Sinus node recovery time and corrected sinus node recovery time during the pacing induced fall in blood pressure was significantly shorter than those during stimulation runs with constant blood pressure. No pacing induced fall in blood pressure and no relation between changes in blood pressure and sinus node recovery time were evident in 10 of the 31 patients. Sinus node recovery time is therefore influenced by alterations in autonomic tone due to pacing induced haemodynamic changes.

Aged↗
PubMed1983

[Hemodynamic studies at rest and under stress in patients with coronary heart disease after administration of carteolol].

In 17 patients with coronary heart disease the influence of the beta-blocking agent 5-(3-tert-butylamino-2-hydroxy-propoxy)-3, 4-dihydro-2(1H)-quinolinone-hydrochloride) (carteolol hydrochloride, Endak, Endak mite) (0.4 mg i.v.) on heart rate, blood pressure, cardiac index, stroke volume index and pulmonary artery pressure at rest and during exercise was investigated. During exercise heart rate and cardiac index decrease significantly (p less than 0.005 and p less than 0.05, respectively). The differences in the stroke volume indices are not significant. The relationship between stroke volume index and mean pressure in the pulmonary artery shows a slight decrease after administration of carteolol at rest and a small increase of the mean pressure in the pulmonary artery during exercise. In patients with coronary heart disease left ventricular function does not change significantly at rest and during exercise after administration of carteolol.

Adult↗
PubMed1981

[Oxygen tension in skeletal muscle in patients with reduced O2-carrying capacity (author's transl)].

In 10 patients (age: 31--72 years) oxygen supply of skeletal muscle was measured by pO2-multiwire technique. All patients suffered from chronic renal failure of differing etiologies and from chronic renal anemia. In muscle tissue 1,128 different O2-tensions were registered and the results were expressed as pO2-histograms. Seven of these pO2-histograms show a normal distribution, three are shifted to the left to lower O2-tensions. Therefore the microcirculation in the skeletal muscle of patients with chronic reduced O2-carrying capacity is largely undisturbed. The microcirculation is able to increase with exercise as shown by a shift to the right in the PO2-histogram. The use of the pO2-multiwire electrode is largely devoid of risk to the patient. Important pathological features may be demonstrated.

Carbon Dioxide↗
PubMed1981

[Depression of sinus nodal automaticity during permanent atrial pacing for the determination of the sinoatrial conduction time (author's transl)].

In 36 patients sinoatrial conduction time (SACT) was calculated by the continuous-atrial-pacing technique, first described by Narula et al. (9). Using three different stimulation frequencies, it could be shown that the return cycles A2A3 and the postreturn cycles A3A4 both were linearly correlated with rising stimulation frequency. Thus, if the formula given by Narula et al. was used [SACT = (A2A3 - A1A1) : 2] the calculated SACT-values linearly rose, too, which was caused by a stimulation frequency dependent progressive depression of the sinus nodal automaticity. This interfering influence of sinus nodal depression could be corrected by applying a modified formula for calculation of the SACT, i.e. SACTM = (A2A3 - A3A4) : 2. Thus calculation of sinuatrial conduction time by the modified continuous-atrial-pacing technique represents a method widely applicable in routine electrophysiological testing.

Electrocardiography↗
PubMed1981

[Measurement of systolic time intervals by echocardiographic and conventional methods (author's transl)].

In 25 patients the systolic time intervals were simultaneously measured by echocardiography and by the conventional method using the ECG, phonocardiogram and indirect carotid pulse tracing. Beat-to-beat-analysis showed no significant difference for QS2 (367.1 +/- 26.7 ms vs. 367.9 +/- 26.5 ms). In contrast, the LVET measured by echocardiography was significantly longer than the LVET taken from the indirect carotid pulse tracing (275.3 +/- 26.3 ms vs. 266.2 +/- 25.9 ms, p less than 0.001). As a consequence, the echocardiographic PEP was significantly shorter than the conventionally measured PEP (91.3 +/- 18.0 ms vs 100.9 +/- 22.7 ms, p less than 0.001). Furthermore, both methods showed the weakest correlation for the ratio PEP/LVET. We conclude that STI can be reproducibly measured by echocardiography, which will lead to significantly different values for the STI compared to those measured by the conventional method.

Adolescent↗
PubMed1980

[The clinical picture of panateritis nodosa].

The clinical picture of the panarteritis nodosa is characterized by vague early symptoms, manifestations in various organs and a changing prognosis. In seven patients with histologically proven panarteritis nodosa the clinical course was followed up over a long period. The commonest early symptoms were fever of unknown origin and a considerable loss of weight. Three out of seven patients showed in the initial phase a hypertension, in two other patients the blood pressure rose as the disease progressed. Those patients, whose renal function was impaired when the diagnosis was established, had a poor prognosis in spite of immunosuppressive therapy and dialysis. The life expectancy of these patients was between two and 16 months (in average 6,4 months). On the other side the clinical course in two patients without renal failure was more favourable; they are alive eight months and 15 years respectively after the diagnosis was confirmed.

Cerebral Hemorrhage↗
PubMed1980

[Atrial versus ventricular cardiac pacing in the elderly with respect to hemodynamic data (author's transl)].

The importance of synchronized atrial and ventricular action is well known. Especially in elderly patients the circulation of the brain, the kidneys and the coronary arteries may be diminished by ventricular stimulation. Permanent atrial, atrial triggered ventricular, and bifocal stimulation increases cardiac output by 20-30 percent. From the hemodynamic data the best results during atrial stimulation are obtained at a frequency of 80 to 85 bpm.

Cardiac Output↗
PubMed1975

Determination of mean whole body intracellular pH in unanesthetized dogs.

In order to determine mean whole body pHi in unanesthetized dogs, assumptions on the urinary and intestinal excretion of DMO, the total loss of an injected single dose of [14C] DMO, and the distribution kinetics of DMO were tested experimentally. Urinary excretion of DMO was almost negligible. The best assumption on the total loss of DMO was based on the exponential decay observed over a period of 1 to 4 weeks. The biological half-life of DMO was 5 days, the time constant being --0.14 d-1. The extracellular distribution of DMO was considered to equal that of [3H] inulin. Between 1 and 7 hours after an injection of inulin in nephrectomized dogs the distribution volume increased linearly from 16% of the body weight after 2 hours to 21% after 6 hours. Based on these experimental results, pHi was determined in 16 unanesthetized dogs. 120 min after the injection of DMO pHi was 7.05 and 430 min after the injection pHi was 7.11. It is concluded that the assumption made allow the estimation of pHi in unanesthetized dogs over a period of 1 to 7 hours.

Acid-Base Equilibrium↗