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Biomedical subjects

F Sacchi

Publications and source records attributed to F Sacchi.

33 records · Page 2Linked to original sources
PubMed1981

Defective bactericidal reaction by the alternative pathway of complement in atopic patients.

Atopic sera were shown to be defective in serum bactericidal activity by a reaction dependent upon the integrity of the alternative pathway of complement activation. In normal human sera, the efficiency of such a reaction could be modulated by the addition of thermostable serum fractions with inhibitory and stimulatory activity, as demonstrated on two different assay systems. Atopic sera contained the inhibitory activities, but no stimulatory activity. The bactericidal defect of atopic sera was shown to be familial, but its hereditary mechanism could not be unambiguously interpreted.

Blood Bactericidal Activity↗
PubMed1979

Disorders of candidacidal activity and other neutrophil functions in three cases of chronic candidiasis.

Three unrelated cases of recurrent and untreatable candidiasis have been followed for about one year. A persistent in vitro defect of neutrophil candidacidal activity characterized the three cases, while other neutrophil functions were shown to be only transiently impaired during the period of observation. None of the three cases could be identified with previously described granulocytopathies.

Candidiasis↗
PubMed1978

A new familial defect in neutrophil bactericidal activity.

A 4-year-old boy with recurrent infections and his clinically healthy father showed a severe, isolated defect in bactericidal activity of peripheral neutrophil leukocytes (the mother and the only sister were normal). Lymph nodes, spleen and liver of the child presented a massive infiltration by macrophages. Such infiltration and the segmentary albinism of the hair resemble traits of the Chediak-Higashi syndrome, but some of the most relevant traits of this syndrome are absent, since all other neutrophil functions were normal in our patient.

Adult↗
PubMedDate not supplied

Defective phagocyte Aspergillus killing associated with recurrent pulmonary Aspergillus infections.

An apparently healthy boy was suffering from recurrent Aspergillus infections. No classical conditions of immunodeficiency were found. Studies on the patient's phagocytic system revealed neutrophils and monocytes to function normally except in Aspergillus killing (microbicidal activity for bacteria and Candida was normal). Aspergillus killing mechanisms may be complex and peculiarly selective, possibly involving both oxygen-dependent and independent mechanisms.

Adolescent↗
PubMedDate not supplied

[Laparoscopic cholecystectomy. Our clinical experience from 1994 to 1996].

BACKGROUND AND AIM: Videolaparocholecystectomy is now regarded as the gold standard of treatment for lithiasis of the gallbladder. METHODS: The authors report a retrospective of 258 consecutive videolaparocholecystectomies performed by the Surgical Division of Valduce Hospital in Como between 1994 and 1996. The authors describe the indications for VLC, techniques for the induction of pneumoperitoneum and the realisation of VLC and the percentage and caused of conversion. RESULTS: During this period a steady reduction was noted in the number of laparotomic cholecystectomies and a parallel increase in cholecystectomies performed using a laparoscopic technique (69.2 vs. 30.8% in 1994; 76.4 vs. 23.2% in 1995; 91.1 vs. 8.9% in 1996). A gradual extension of the indications for laparoscopic surgery can be seen leading to the application of this technique in patients suffering from acute cholecystic infection, hydros or empyema of the gallbladder. Conversion were required in 25 cases in this series (9.7%). During the last year analysed there were a total of 9 conversions (7.9%) even though the percentage of acute cholecystitis accounted for 38.9% of all cases of cholecystectomy. CONCLUSIONS: In line with the experience of other centres, the authors, currently propose VLC as the treatment of choice for lithiasic pathologies of the cholecyst.

Acute Disease↗