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Biomedical subjects

F Salamon

Publications and source records attributed to F Salamon.

At least 37 records · Page 2Linked to original sources
PubMed1984

Adenine arabinoside in severe thrombocytopenia due to hemorrhagic varicella.

An 18-year-old man, admitted because of severe bleeding manifestations due to varicella thrombocytopenia was administered 800 mg/day adenine arabinoside (Ara-A) intravenously for 5 days. 2 days after the start of this treatment the bleeding phenomena became markedly reduced and a progressive increase in the platelet count was noted thereafter. Although a spontaneous improvement is known to occur in patients with varicella thrombocytopenia, the rapid clinical improvement after the Ara-A administration is suggestive for its beneficial effect in the presented patient.

Adolescent↗
PubMed1984

Effects of (+)-cyanidanol-3 on chronic liver injury.

Thirty patients of both sexes, suffering from alcoholic or diabetic liver injury, were studied in order to establish therapeutic effects of daily 3000 mg (+)-cyanidanol-3 administered for 3 weeks. In addition to subjective complaints, alterations in liver-specific enzyme-levels, changes in serumlipoids, the BSP half-time, activity of the microsomal enzyme-system and changes in the diabetic metabolism were studied. During the observation significant improvement of the disturbed enzyme-activities, decrease of the high lipoid level, reduction of the BSP half-time and the increasing activity of the microsomal enzyme-system could be proved. In case of diabetic patients a favourable change of the metabolic status could be established. Subjective complaints of patients subsided. In case of 17 patients the radionuclide HIDA method was applied too in order to study the dynamics of bile-transport. A moderately significant acceleration of the bile-transport could be observed. While continuing the treatment of 15 patients for 6 months, a control liver biopsy was carried out and in 10 cases it revealed favourable changes in the histological finding. During cyanidanol treatment gastrointestinal intolerance was observed in two patients, but only temporarily. Immune haemolysis did not occur.

Adult↗
PubMed1979

Effect of ACTH-stimulated glucocorticoid hypersecretion on the serum concentrations of thyroxine-binding globulin, thyroxine, triiodothyronine, reverse triiodothyronine and on the TSH-response to TRH.

The responses of serum concentrations of TSH, thyroxine (T4), triiodothyronine (T3) and of reverse triiodothyronine (rT3) to i. v. administration of 0.4 mg THR were examined prior to (and after) i. m. administration of ACTH (2 mg Synacthen Depot) in 7 euthyroid women using estrogen-containing oral contraceptives and in 8 controls, with the following results: (1) an increase in endogenous glucocorticoid secretion is associated with a depression of the TSH response to TRH; (2) TSH formed in decreased amounts is still capable of stimulating thyroid secretion; (3) the increased serum corticoid levels fail to affect the secretory response of the thyroid to TSH; (4) control of the pituitary-thyroid axis remains normal in the presence of increased serum thyroxine-binding globulin (TBG) levels. In a further series the serum levels of TBG, T4, T3, rT3 and cortisol under the effect of ACTH-induced endogenous glucocorticoid hypersecretion were studied in 6 normal untreated controls, in 6 normal women using oral contraceptives and in 10 untreated hyperthyroid patients. During four days subsequent to treatment the serum TBG levels decreased, maximum decrease being found in the users of oral contraceptives, minimum decrease in the controls. Serum T4 was found to decrease during 2 to 4 days, serum T3 parallel with an increase in serum rT3, for 1 to 2 days, subsequent for ACTH loading. In the euthyroid cases also the serum TSH levels showed a transitory decline. It is concluded that in case of endogenous hyperproduction of glucocorticoids (1) T4 leads to T3 monodeiodination decreases and T4 leads to rT3 conversion increases parallel with the changes in the serum cortisol levels; (2) TBG synthesis is inhibited by endogenous glucocorticoids; (3) the changes in serum TBG levels are accompanied by a decrease in the serum T4 concentrations.

Adrenocorticotropic Hormone↗