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Biomedical subjects

F Sano

Publications and source records attributed to F Sano.

At least 19 recordsLinked to original sources
PubMed1992

[Salvage therapy for recurrent or refractory non-Hodgkin's lymphoma with etoposide, methotrexate, vindesine and prednisolone (EMVP)].

Seventeen patients with recurrent or refractory non-Hodgkin's lymphoma were treated with EMVP (Etoposide 75 mg/m2 i.v. d 1-5, Methotrexate 100mg/m2 i.v. d 1, Vindesine 3 mg/body i.v. d 1, Prednisolone 60 mg/m2 p.o. d 1-5), repeating every 3 weeks. Six complete responses (35%) and five partial responses (30%) were obtained with an overall response rate of 65%. The median duration of response was 26 months (range 8-49+months) for complete response (CR) and 4 months (range 2-6 months) for partial response (PR). The median duration of survival was 31 months for CR, 11 months for PR and 10 months for all patients, respectively. The major toxic effect was myelosuppression. Leukopenia less than 1,000/mm3 and thrombocytopenia less than 25,000/mm3 occurred in 5 and 3 patients, respectively. The other toxicities were alopecia, nausea and mucositis. However, these toxicities were well tolerated and clinically manageable. These results suggested that EMVP therapy was an effective regimen for patients with recurrent or refractory lymphoma.

Adult↗
PubMed1991

[Thrombotic thrombocytopenic purpura associated with myasthenia gravis].

A case of thrombotic thrombocytopenic purpura (TTP) associated with myasthenia gravis (MG) is reported. A 56-year-old woman was admitted to our hospital on April 27, 1988, because of easy fatigue and double vision. She was diagnosed as having myasthenia gravis from her neurological and laboratory findings. On the 14th hospital day, she developed fever, jaundice, hematuria, purpura and consciousness disturbance. Hematological examination revealed marked anemia, thrombocytopenia, fragmented red blood cells, elevated bilirubin and LDH level. Coagulation studies were almost normal. She was diagnosed as having TTP and treated with corticosteroid, antiplatelet agents and plasma exchange. Clinical condition and laboratory findings improved by the 23rd hospital day. It has been reported that TTP is associated with various autoimmune disease such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome or idiopathic thrombocytopenic purpura. However TTP associated with MG appears the first report. This case may suggest that one of pathogenesis of TTP is autoimmune mechanism.

Autoimmunity↗
PubMed1990

Body weight and longevity: insurance experience in Japan.

Adverse effects of obesity on health and longevity are widely known in clinical medicine. The author reports here the result of a study on the relationship of body weight and longevity based on the data obtained by the life insurance cohort study in which he participated. The result is summarized below: 1. Mortality by body weight assumed a U-shaped curve with the nadir near the average weight for both men and women. 2. Because the mortality for some causes went upward toward right or reverse with the shift from underweight to overweight, the curve for all-cause mortality became U-shaped. 3. The relationship between hospitalization ratio and body weight showed substantially the same trend although the cause for hospitalization varied. 4. The body weight showing the lowest mortality was slightly heavier than the average body weight in Japan, which was different from North America. 5. Based on Metropolitan Life's principle of lowest mortality, we published Meiji Life's height and weight tables in order to set the standard body weight for the Japanese today.

Body Weight↗
PubMed1990

[Augmentation of pirarubicin cytotoxicity by chlorpromazine in doxorubicin-resistant mouse P388 leukemia cells].

The intracellular uptake, retention and cytotoxicity of pirarubicin, an anthracycline derivative, combined with chlorpromazine were investigated in doxorubicin-resistant mouse P388 leukemia (P388/DXR) cells. The number of viable cells was determined by the dye exclusion method. Chlorpromazine increased the cytotoxicity of pirarubicin in a dose-related manner in P388/DXR cells. A similar dose-response relationship was observed for chlorpromazine in increasing net intracellular pirarubicin accumulation. The accumulation was based on block of enhanced pirarubicin efflux from resistant cells by chlorpromazine. However, chlorpromazine did not affect cytotoxicity or transport of pirarubicin in the drug-sensitive cell line. The possible mechanisms of the restoration of pirarubicin sensitivity in P388/DXR cells by chlorpromazine are discussed.

Animals↗
PubMed1990

[A case of non-functioning adrenocortical tumor].

A resected case of a non-functioning adrenocortical tumor is reported. The patient's chief complaint was fever and general fatigue. Computed tomography and ultrasonography revealed the suspected presence of a tumor on the right lobe of the liver, though a definite diagnosis of a right adrenal tumor was reached after hepatic angiography. An endocrinal examination, however, showed no abnormality. The tumor was dissected sharply from the right hepatic lobe and completely removed with a part of the diaphragm. It measured 10 x 12 x 18 cm and weighed 1,280 g. Hemorrhagic and necrotic changes were noted in the cut section, and a subsequent pathological examination revealed an adenocarcinoma of the adrenal cortex. An administration of 5-FU was given orally and the patient's progress has gone well without a recurrence or a metastasis for 4 years and a month since the surgery.

Adenocarcinoma↗
PubMed1989

Liver resection using a water jet.

The water-jet method has been used during hepatic resection. The instrument cuts the hepatic tissue with the high pressure of the fine water flow, while the exposed elastic intrahepatic vessels are spared injury. A comparative study on the water-jet method with the previously employed conventional methods was undertaken. Hepatic resections were performed on 35 patients using the water-jet method. Cirrhosis of the liver was associated with 10 of the 24 patients with hepatocellular carcinoma. An ordinary saline solution was used as the jet, which was projected at a pressure of between 12 kg/cm2 and 20 kg/cm2 through a 0.15/mm-diameter nozzle. A higher jet pressure was needed to cut the fibrotic hepatic parenchyma. In the case of normal liver, the intrahepatic vessels of more than 0.2 mm were well preserved. In most of the cases, the loss of blood when cutting the hepatic parenchyma can be easily reduced with a jet pressure of 15-16 kg/cm2, thus preserving the fine vessels more than 0.2 mm in diameter without injury. When the same pressure was applied in the cutting of a cirrhotic liver, it took much longer time compared to that of a non-cirrhotic normal liver parenchyma. The cut surface was smooth compared to that after using CUSA, although its disadvantages lie in the formation of air bubbles, which obscure the operative field. The controlled projection of a jet of water under optimal pressure may ensure a safe hepatic resection of both normal and cirrhotic livers. Furthermore, because of its uncomplicated form, a wide range of applications can be expected, while the lower cost will also expedite its large-scale use for economic reasons.

Adolescent↗
PubMed1989

[Primary pulmonary cryptococcosis treated with transbronchial injection of amphotericin B].

A 76-year-old man was admitted because of multiple nodular opacities in both lungs on chest X-ray. Cryptococcus was identified in the specimens obtained from bronchial brushing and bronchial washing. Primary pulmonary cryptococcosis was diagnosed as he had no underlying diseases and no foci in any other organs except the lung. Transbronchial injection (TBI) of amphotericin B was administered to the largest focus, in addition to the intravenous administration of miconazole. The chest tomogram 25 days after the first TBI showed marked decrease in the size of the largest focus, but no improvements were observed in other foci. TBI can be performed easily and safely, and perhaps more effectively than administration of amphotericin B with aerosol. This procedure may be of value in the treatment of pulmonary cryptococcosis.

Aged↗
PubMed1989

[Clinical evaluation of CA-50 in cases with colorectal cancer].

Serum CA-50 has been evaluated in 67 healthy donors and in 46 patients with a colorectal cancer by an enzyme immunoassay (EIA Kit, Mitsui pharmaceuticals, Inc.). The mean value of the healthy donors (n = 67) was 10.6 +/- 6.1 U/ml and for patients with a colorectal cancer 31.7 +/- 55.2 U/ml. Both in healthy donors and in patients, the mean value was found to be higher in females than males. The overall sensitivity in the colorectal cancer patients was 26.1 percent, the percentages for those in stage I, 20, II, 9.1, III, 40, IV, 20, and V, 50% respectively. In a correlation between serum CA-50 and CA 19-9, the correlation coefficient was 0.82 (p less than 0.01), and in between CA-50 and CEA, 0.51 (p less than 0.01). Thus a combination assay among CA-50, CA 19-9, and CEA has proved to be of significant value in cases of a colorectal cancer.

Antigens, Tumor-Associated, Carbohydrate↗
PubMed1988

Lack of effect from a single cigarette challenge on bronchial responsiveness in healthy non-smoking subjects.

The effect of smoking a cigarette on bronchial responsiveness was studied in healthy non-smokers. Twenty two subjects performed a methacholine inhalation test before and after smoking a single cigarette. Ten of the subjects took part in a further study in which propranolol was inhaled before the smoking challenge to diminish the baseline beta adrenergic tone of the airway. After they had smoked a single filtered or non-filtered cigarette the indices of bronchial responsiveness (the cumulative dose of methacholine starting a decrease in the reciprocal of resistance, Grs (Dmin), and the cumulative dose causing a 35% drop in the Grs (PD35Grs)) did not change significantly. With the inhalation of propranolol mean (SD) log Dmin decreased from 1.37 (0.44) units to 0.74 (0.57) (p less than 0.01) and log PD35Grs from 1.93 (0.38) to 1.51 (0.38) (p less than 0.01). Smoking a single cigarette after the inhalation of propranolol did not, however, cause any further change in bronchial responsiveness. This study suggests that smoking a single filtered or non-filtered cigarette does not change bronchial responsiveness in non-smokers, and that changes in beta adrenergic tone of the airway do not modify the effect of smoking a single cigarette on bronchial responsiveness.

Adult↗
PubMed1988

Effects and mechanism of fenoterol on fatigued canine diaphragm.

We have studied the effects and mechanism of fenoterol (a beta 2-agonist) on contractility of the fatigued canine diaphragm. Transdiaphragmatic pressure (Pdi) was measured by a pair of balloons, and diaphragmatic contractility was assessed from changes in tetanic contraction, produced by supramaximal electrical stimulation of the phrenic nerves. Diaphragmatic fatigue was developed by applying an inspiratory resistive load to a spontaneously breathing dog for approximately 30 min. Fenoterol improved the Pdi of the fatigued canine diaphragm at all stimulation frequencies, and the increases in Pdi at low frequencies were greater. The potentiation of Pdi by fenoterol occurred in a dose-dependent manner with doses of 2.5 to 10 micrograms/kg and was equal to that of aminophylline. Dibutyryl cyclic AMP did not have significant effect on the Pdi at all stimulation frequencies. The augmentation of Pdi in the fatigued diaphragm by fenoterol was abolished by administration of a calcium antagonist, verapamil, and fenoterol did not change the diaphragmatic contractility in nonfatigued dogs. We thus have concluded that fenoterol improves contractility in the fatigued canine diaphragm and the effect might be brought about by an increased influx of calcium to the muscle cell.

Aminophylline↗
PubMed1988

[Clinical evaluation of a combination assay of CEA, CA-19-9 and TPA in patients with colorectal cancer].

The effectiveness of serum CEA (56 cases), CA-19-9 (53 cases) and TPA (48 cases) in patients with colorectal cancer has been evaluated. The preoperative sensitivity and specificity of CEA and CA 19-9 were found to be almost the same in level but the level of TPA was low. In 20 cases recurrent, the sensitivity of the marker was 66.7% in the liver, 60% in the lung, and 66.7% in the local recurrence of primary foci. In these recurrent cases, serum CEA in initially elevated to 65%, CA 19-9 to 25%, and TPA to only 10%. In diagnostic rate imaging or in our clinical findings, however, the frequency was almost the same as tumor markers.

Antigens, Tumor-Associated, Carbohydrate↗