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Biomedical subjects

F Santos Rodríguez

Publications and source records attributed to F Santos Rodríguez.

14 recordsLinked to original sources
PubMed2004

[Acute renal failure in critically-ill children. A preliminary study].

OBJECTIVE: To analyze the characteristics of acute renal failure (ARF) in critically-ill children and develop a protocol for a multicenter study. METHODS: A prospective, descriptive study was performed in four pediatric intensive care units (PICU) over 5 months. Epidemiological, clinical and laboratory data from children aged between 7 days and 16 years with ARF were analyzed. Premature neonates were excluded. RESULTS: There were 16 episodes of ARF in 14 patients and 62.5 % were male (mean 6 SD age: 50 +/- 49 months). The incidence of ARF was 2.5 % of PICU patients. The most frequent primary diseases were nephro-urological (50 %) and heart disease (31 %). The main risk factors for ARF were hypovolemia (44 %) and hypotension (37 %). Six patients (37.5 %) developed ARF following surgery (cardiac surgery in four, kidney transplantation in one and urological surgery in one). Furosemide was used in 13 patients (as continuous perfusion in nine), inotropes in nine and renal replacement therapy in 12. Medical complications were found in 94 % and some organic dysfunction was found in 81 %. The length of stay in the PICU was 21 +/- 21 days. The probability of death according to the Pediatric Risk of Mortality was 14 +/- 8 %. Five patients died (36 % of the patients and 31.2 % of ARF episodes). CONCLUSIONS: The incidence of ARF in critically-ill children is low but remains a cause of high mortality and prolonged stay in the PICU. Mortality was caused not by renal failure but by multiple organ failure.

Acute Kidney Injury↗
PubMed2003

[Ambulatory blood pressure monitoring in multicystic dysplastic kidney disease].

OBJECTIVE: To evaluate blood pressure in a group of patients with multicystic dysplastic kidney (MDK) disease through ambulatory blood pressure (ABP) monitoring. PATIENTS AND METHODS: ABP monitoring was performed in 16 patients with MDK disease using a Spacelabs 90207 monitor and an appropriately sized armband. The patients performed their normal daily activities except physical exercise. The activity period was 8:00 am to 8:00 pm and the resting period was midnight to 6:00 am. Patients with a percentage of correct readings of less than 70 % were excluded. The mean systolic and diastolic blood pressures for each period were calculated. Circadian variability was determined by the ratio between mean systolic and diastolic values in the active and resting periods, respectively. The results were compared with ABP values in healthy children. RESULTS: Fourteen patients (mean age 16 3.1 years, range: 6-27.6) were included. No patients with hypertension were found through casual measurement. One patient had daytime systolic hypertension. Five patients presented an abnormal drop in blood pressure during sleep. CONCLUSION: Blood pressure should be monitored in patients with MDK disease. ABP monitoring may detect alterations that can go unnoticed in casual determinations. Further studies with large samples are needed to establish the real prevalence of hypertension in these patients.

Adolescent↗
PubMed1997

[Influence of diet in idiopathic hypercalciuria].

OBJECTIVES: To find out if differences in diet may justify the presence of idiopathic hypercalciuria (IH) and to verify if the calcium-restricted diet, often recommended for treatment of IH, is nutritionally appropriate. PATIENTS AND METHODS: Dietary intake and mineral and electrolyte urinary excretion were studied twice in 10 children diagnosed of IH and in 9 controls. First, while being on a free diet. Second, after a week of suppression of milk and dairy products. RESULTS: Intakes of calories, proteins, carbohydrates, fats, and minerals were similar in IH patients and controls. Withdrawal of dairy products of diet resulted in an important reduction in the intakes of calcium (71.1%), phosphorus (63.5%) and fats (30.1%), although only calcium intake was remarkably below international recommendations (33.6 +/- 10.4%). CONCLUSIONS: Spontaneous diet of this group of hypercalciuric children was no different from that of control children. Suppression of milk and dairy products causes a nutritionally inappropriate diet.

Adolescent↗
PubMed1993

[Urinary concentration capacity in neonatal hydronephrosis].

In order to determine the renal concentration capacity in neonatal hydronephrosis, 10 micrograms of DDAVP were administered intranasally to 18 infants with hydronephrosis. Fluid intake was restricted to 50% of normal for 3 hours before and 6 hours after the administration of DDAVP. Maximal urine osmolality (mean +/- SD) was 348 +/- 180 mOsm/kg in 7 newborns younger than 21 days and 420 +/- mOsm/kg in 11 neonates between 22-50 days of age. Both osmolarities were inferior to the standard response to DDAVP reported in normal neonates. After 24 hours of clinical observation, we did not notice any secondary effects caused by this test.

Deamino Arginine Vasopressin↗
PubMed1992

[Type 1 diabetes mellitus and nephropathy. Predicting factors in pediatric age].

OBJECTIVE: To find the existence of early relationships between alterations in the glucidic metabolism and the glomerular and tubular basal function in diabetic insulin-dependent children without clinical evidence of diabetic nephropathy (DN). METHODS: We determined blood pressure, basal plasma concentrations of glucose, glycosilated hemoglobin and total proteins, glomerular filtration rate (GFR), and the glucose, proteins, calcium, phosphorus, uric acid, sodium, potassium and chloride excretions in diurnal, nocturnal and 24-hour urine samples in 43 diabetic children and 13 healthy controls. RESULTS: The microproteinuria mean value in all urine samples (always less than 15 micrograms/min/1.73 m.2), the GFR and blood pressure were similar in both groups. In the diabetic children, we found an inverse correlation between age and 24-hour urine microproteinuria (r-0.33; p less than 0.05) and between age and nocturnal urine microproteinuria (r-0.35; p less than 0.05). There was also a highly significant correlation between microproteinuria and the albumin/creatinine ratio in urine samples (r = 0.94, p less than 0.0001). Diabetic children showed a greater nocturnal excretion of calcium (p less than 0.05) and phosphorus (p less than 0.05). CONCLUSIONS: Our results suggest that microproteinuria, GFR and blood pressure have not served as predictors of DN in pediatric patients.

Age Factors↗
PubMed1991

[Nephrotic syndrome in infancy: clinical, therapeutic and follow up characteristics in 100 cases].

In order to understand the natural history, clinical features, anatomopathological findings and response to the initial treatment with steroids of the nephrotic syndrome (NS) during childhood, a group of 100 children under 14 years (46 with renal biopsy) observed for an average period of 4 years and 8 months, was reviewed retrospectively. The patients were divided into 3 groups: idopathic NC (89), secondary NS (9) and NS in the first six months of life (2). In the group of idiopathic NS, in which the significant predominance of males (2.8/1) was confirmed, in 69% of the patients the diagnosis was made between the ages of 2 and 5 years. Edemas were found, sometimes accompanied by oliguria and weigh gain, in 77% of the cases. The periods of hypertension and hematuria were infrequent and brief. Thirty eight kidney biopsies were carried out and showed: 25 minimal changes NS, 7 diffuse mesangial proliferative glomerulonephritis (DMPGN), 3 membranoproliferative glomerulonephritis (MPGN), 2 membranous glomerulonephritis (MGN) and 1 segmental and focal glomerulosclerosis. Of the 83 patients treated in first instance with corticosteroids, a positive response was obtained in 72 (87%), although 44% of them have shown to be cortico-dependent. After an average follow up period of 4 years and 8 months, only 2 children, one with MPGN and the other with MGN, are now in chronic renal failure (CRF). In 5 ot the 9 patients included in the second group, the NS was secondary to a Henoch Schönlein purpura. The kidney biopsies showed DMPGN in three of them.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenal Cortex Hormones↗
PubMed1990

[Management of chronic non-terminal renal failure in childhood. Estimation of mean annual cost].

We have calculated the mean annual cost (MAC) referred to 1,988 pesetas derived from the treatment and surveillance of 15 patients diagnosed of non terminal chronic renal failure (NT-CRF). The patients were aged between 1 month and 12 years at the moment of diagnosis and they were followed-up for five years at least. We have differentiated among costs from hospitalization, pharmacological treatment and outpatient control which were respectively 455,400, 47,798 and 57,917 pesetas/patient year. The costs from hospitalization decreased progressively every year after diagnosis being of 21,211 pesetas/patient year at the 5th year from diagnosis. The 30.1% of pharmacological treatment costs were due to the use of alkalines, 23.4% to phosphorus quelants (calcic carbonate mainly) and 27.3% to the active forms of vitamin D3. The outpatient surveillance costs corresponded 24,000 pesetas/year to staff expenses, 27,492 pesetas/year to laboratory work-up and 6,424 pesetas/year to radiological examination. We conclude that the total MAC for children with NT-CRF eas 561,115 pesetas/patient being the hospitalizations costs the most important concept (81.2%), followed by ambulatory care (10.3% and drug treatment (8.5%).

Ambulatory Care↗
PubMed1989

[Chronic renal insufficiency in 22 children: diagnosis and evolution].

Clinical characteristics, evolution of growth, and glomerular rate were analysed in 22 patients, younger than 14 years, with chronic renal failure (glomerular filtration rate: 32.6 +/- 24.8 ml/min/1.73 m2, x +/- DS) with a minimal follow-up of 6 months (3.5 +/- 3.3 years). Recurrent urinary tract infections were the most common initial clinical features (27%) and obstructive uropathies constituted the most frequent etiology (41%). Renal failure progression rate, which was assessed by means of 1 to serum creatinine concentration ratio, was faster in the group of children with glomerulonephropaties. At the diagnosis, one out of 3 children had short stature. At the end of the follow-up time, the delay of growth did not significatively modified (-1.6 +/- 2.2 DS versus -2.1 +/- 1.2 DS, p greater than 0.05).

Child↗
PubMed1987

[Effect of treatment with 1,25-dihydroxyvitamin D3 in children with chronic renal insufficiency].

The effect of 1,25-dihydroxyvitamin-D3 administration on growth rate, renal failure progression and calcium-phosphorus metabolism was evaluated in 8 children younger than 13 years, mean age 6.3 +/- 3.3 (mean +/- SD), with chronic renal failure (glomerular filtration rate: 44.1 +/- 16.5 ml/min/1.73 m2) receiving conservative treatment in whom at least two periods, with a minimal duration of six months each, without and with rocaltrol treatment, could be compared 1.25-dihydroxyvitamin-D3 at dosage of 16.3 +/- 6.3 ng/kg/day resulted in a significant increase (p less than 0.05) of growth index velocity (81.4 +/- 37.8 versus 122.4 +/- 60.3) without altering renal failure progression rate which was assessed by means of 1 to serum creatinine concentration ratio. One hypercalcemic episode (serum calcium equal or greater than 11 mg/dl) every 28.4 months was observed. Our results confirm the beneficial effect of 1.25-dihydroxyvitamin-D3 administration in the management of children with chronic real failure.

Calcitriol↗