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Biomedical subjects

F Sardella

Publications and source records attributed to F Sardella.

At least 19 recordsLinked to original sources
PubMed2003

Myositis ossificans as a complication of a muscle tendon junction strain of long head of biceps. A case report.

An unusual case of myositis ossificans secondary to a muscle tendon junction (MTJ) strain of long head of biceps in a young athlete is reported. Plain radiographs, ultrasonography and MRI in association with clinical assessment showed the appearance and the evolution of this pathological entity. This case had a resolution of pain and function after 3 months of conservative treatment. At 6 months follow-up, the athlete became asymptomatic and he gradually returned back to his sports activity.

Adolescent↗
PubMed2001

VO2 slow component correlates with vastus lateralis de-oxygenation and blood lactate accumulation during running.

BACKGROUND: In the present study, vastus lateralis de-oxygenation was monitored contemporarily with VO2 changes along a severe constant intensity running exercise, after the 3rd min up to volitional exhaustion. Blood lactate accumulation was also measured before, during and after running. METHODS: Eleven male amateur soccer players volunteered for the study. Subjects mean age, height, and body weight were 22.9+/-2 yrs, 177.5+/-6.2 cm, 71.7+/-4 kg, respectively. Measurements were carried out during running on a treadmill. Ventilatory and gas exchange parameters were measured at the mouth on a breath-by-breath basis. For blood lactate concentration accumulation measurement, capillary blood samples were taken from the fingertip. The oxygenation of the vastus lateralis muscle were measured by a continuous wave NIRS portable instrument. By means of two pretests the onset of [La]b accumulation and its associated velocity (vOBLA), and the peak of oxygen uptake and its associated velocity (vVO2,peak) were assessed. The test consisted of running on the treadmill up to volitional exhaustion at a constant velocity corresponding to vOBLA plus 50% of the difference between vVO2,peak and vOBLA (v50%Delta). RESULTS: The principal finding of this study was that vastus lateralis de-oxygenation changes measured during running correlate with a) oxygen uptake changes between the 3rd min of exercise and the time corresponding to the subject's volitional exhaustion; b) blood lactate concentration increments measured at the 3rd and the 6th min of exercise and at the time corresponding to the subject's volitional exhaustion. CONCLUSIONS: In conclusion, the results of the present study support our hypothesis that the vastus lateralis de-oxygenation contributes consistently to the VO2 slow component development in running.

Adult↗
PubMed2000

Preparatory versus main competitions: differences in performances, lactate responses and pre-competition plasma cortisol concentrations in elite male swimmers.

Two groups of elite male swimmers were studied using a similar protocol during the winter training seasons of two consecutive years. In the first season (September 1997-January 1998), eight male swimmers (age 19-25 years) of the Italian National Team participated, after 12 weeks of increased training volume, in a preparatory national competition (PWC) and then, after a further 6 weeks of specific training, in the World Championships (WC, both competitions in a 50-m pool), which represented the main competition at the end of the 18-week-long winter season. In the second season (September 1998-December 1998), a group of ten high-level male swimmers (18-22 years) participated, after 8 weeks of increased training volume, in a preparatory national competition (PIC) and then, after a further 6 weeks of specific training, in the Italian Championships (IC, both competitions in a 25-m pool), the main competition at the end of the 14-week-long winter season. A tapering period lasting 1-3 weeks was observed before the main competition in both seasons. All swimmers were competing at distances of up to 400 m; two of them participated in the study in both seasons. The swimming velocities and post-competition blood lactate concentrations were higher in the main competitions than in the preparatory competitions in both seasons. Pre-competition plasma cortisol (CORT) concentrations were higher than the initial values at the beginning of the season, reaching maximal values at the preparatory competitions and then decreasing before the main competitions in both seasons. The percentage increase in individual swimming velocity from the preparatory to the main competition was positively correlated with the corresponding increase in post-competition blood lactate (r = 0.63, P = 0.046) in the 1997 season (WC), and negatively correlated with the corresponding decrease in pre-competition CORT concentration (r = -0.66, P = 0.019) in the 1998 season (IC). Our results indicate that a decrease in pre-competition CORT could be a prerequisite for an improvement in swimming performance.

Adult↗
PubMed1997

[A case of arterial hypertension after use of oral contraceptives].

It is known that oral contraceptives may induce high blood pressure that usually returns to normal values a few weeks after interruption of the drugs, and without any specific treatment. The precise mechanism by which oral contraceptives cause hypertension is not clear. A severe hypertension and mild heart failure in a young woman using oral contraceptives has been observed in the case described. The patient needed a careful and prolonged therapy to maintain a normal blood pressure.

Adult↗
PubMed1996

A comparison of time to exhaustion at VO2 max in élite cyclists, kayak paddlers, swimmers and runners.

A recent study has shown the reproducibility of time to exhaustion (time limit: tlim) at the lowest velocity that elicits the maximal oxygen consumption (vVO2 max). The same study found an inverse relationship between this time to exhaustion at vVO2 max and vVO2 max among 38 élite long-distance runners (Billat et al. 1994b). The purpose of the present study was to compare the time to exhaustion at the power output (or velocity) at VO2 max for different values of VO2 max, depending on the type of exercise and not only on the aerobic capacity. The time of exhaustion at vVO2 max (tlim) has been measured among 41 élite (national level) sportsmen: 9 cyclists, 9 kayak paddlers, 9 swimmers and 14 runners using specific ergometers. Velocity or power at VO2 max (vVO2 max) was determined by continuous incremental testing. This protocol had steps of 2 min and increments of 50 W, 30 W, 0.05 m s-1 and 2 km-1 for cyclists, kayak paddlers, swimmers and runners, respectively. One week later, tlim was determined under the same conditions. After a warm-up of 10 min at 60% of their vVO2 max, subjects were concluded (in less than 45 s) to their vVO2 max and then had to sustain it as long as possible until exhaustion. Mean values of vVO2 max and tlim were respectively equal to 419 +/- 49 W (tlim = 222 +/- 91 s), 239 +/- 56 W (tlim = 376 +/- 134 s), 1.46 +/- 0.09 m s-1 (tlim = 287 +/- 160 s) and 22.4 +/- 0.8 km h-1 (tlim = 321 +/- 84 s), for cyclists, kayak paddlers, swimmers and runners. Time to exhaustion at vVO2 max was only significantly different between cycling and kayaking (ANOVA test, p < 0.05). Otherwise, VO2 max (expressed in ml min-1 kg-1) was significantly different between all sports except between cycling and running (p < 0.05). In this study, time to exhaustion at vVO2 max was also inversely related to VO2 max for the entire group of élite sportsmen (r = -0.320, p < 0.05, n = 41). The inverse relationship between VO2 max and tlim at vVO2 max has to be explained, it seems that tlim depends on VO2 max regardless of the type of exercise undertaken.

Adolescent↗
PubMed1995

Scintigraphic recording of blood volume shifts.

UNLABELLED: A scintigraphic device consisting of small scintillation probes tightly fixed to the skin was developed to record intravascular blood volume shifts continuously and simultaneously at several sites. The aim of the present study was to ascertain the reliability of the measurements obtained, show the blood shifts induced by common daily activities in healthy subjects and clarify the mechanisms responsible for hemodynamic changes. METHODS: Measurements were made in three fields of the right lung, the liver, thighs and calves of 16 men during Valsalva maneuver, hyperventilation, various posture changes and treadmill walking. Some tests were repeated. RESULTS: The measured blood volume shifts were always in the expected direction and in accordance with those reported in the literature; they also were reproducible. Therefore, the measurements were reliable. A pattern of blood volume changes peculiar to some common daily activities was recorded in subjects moving freely. Insights were obtained on the mechanisms responsible for the blood volume shifts. CONCLUSION: Our noninvasive technique provides reliable continuous measurements of blood volume changes at several sites during common daily activities and could be applied not only in healthy subjects but also in patients.

Activities of Daily Living↗
PubMed1995

Pulmonary gas exchange in athletes with exercise-induced hypoxaemia.

Hypoxaemia that is induced by physical exercise (EIH) in some athletes, who are however capable of enduring intense muscolar work, is a phenomenon that has been known for some time. However, assumptions such as alveolar hypoventilation, veno-arterial shunt, limitation of diffusion, or mismarch of the VA/Q ratio, have not to date been able to exhaustively explain this phenomenon. In this study five athletes displaying exercise-induced hypoxaemia were evaluated by increasing-load exercise tests, as proposed by other authors, and by means of intermittent tests with supermaximal exercise steps (130% VO2 max) with breaks for incomplete recovery (3 min). The fundamental fact arising from our study is that the intermittent tests did not bring about hypoxaemia in the tests subjects. Analysis of the ventilator and metabolic parameters, of the alveolar pressure of the O2, and of the partial pressures of the CO2 in the arterial blood, all measured during the two different types of muscular exercise, lead to the belief that the different distribution of the pulmonary blood flow, which has been documented in highly trained athletes, plays a very important role in inducing EIH.

Adaptation, Physiological↗
PubMed1994

A new respiratory valve system for measuring oxygen uptake during swimming.

We describe a new respiratory valve system with minimal dead space, which allows measurement of ventilation and oxygen uptake during swimming. The device offers considerable advantages in efficiency and accuracy over current equipment, and can be used in conjunction either with a miniaturized telemetry system for oxygen uptake measurement or with a conventional system. The valve has a low airflow resistance, a small dead space (15 ml), and an electrically operating, closed-circuit pump to remove excess water from the expiratory tube. The external form and the buoyancy of the valve have been hydrostatically and hydrodynamically designed to reduce drag and to ensure a correct mass in the water. To obtain this result a very sophisticated material, carbon fibre, has been utilized. Our studies showed that this respiratory system is ideal for obtaining valid and reliable values of oxygen uptake during swimming, even at high speed and in endurance swimming tests.

Air Pressure↗
PubMed1993

Simultaneous recording of blood volume shifts in different vascular beds in man by a versatile scintigraphic method.

A device was developed to record the blood volume changes occurring in the lung and calf during postural changes, physical exercise, and the Valsalva maneuver in man. The changes in regional counting rates from the right middle lung and the calf mirrored the well-known changes in venous return that are expected to occur in response to the above-mentioned external stimuli. Thus a sustained decrease in lung blood volume was noted on assumption of the erect posture as well as during the forced expiration of the Valsalva maneuver. In addition a rapid increase and a sharp decrease in lung blood volume took place at the very onset and at the very end of walking, respectively. The calf blood volume declined immediately at the onset of walking, increased slightly in the ensuing two minutes, and returned to baseline quickly at the termination of walking. The authors' method enables real-time equilibrium blood pool scintigraphy to be recorded continuously and simultaneously from different districts over sustained periods of time irrespective of the posture and the physical activity performed by the patient. Their method might improve knowledge of the systemic circulatory responses to selective physiologic and therapeutic interventions in health and disease.

Blood Volume↗
PubMed1993

Blood lactate accumulation in top level swimmers following competition.

The purposes of this study were to evaluate the significance of blood lactate values after competitions and the blood lactate-swimming speed relationship to swimming performances. Auricular blood samples (N = 421) were collected in 203 top level Italian swimmers (116 males and 87 females) at the end of competitions performed in a 25 m swimming pool. The distribution of all lactate values differed between males and females. The lowest lactate values occurred in swimmers performing the longest distances both in males (1500 m) and females (800 m). In swimmers performing freestyle events a relationship between V-4 mM (swimming speed at 4 mmol/l blood lactate value) and competition velocities was observed, in males, at 200, 400 and 1500 m and, in females, at 400 and 800 m. The predicted velocity corresponding to the competition lactate value assessed by the individual blood lactate-swimming speed relationship was found to be highly related to the actual competition velocity. Results suggest that blood lactate values in swimmers are a useful indication of individual aptitudes.

Adolescent↗
PubMed1989

[Personal experiences concerning the usefulness of the exercise test in the diagnosis of ischemic heart disease in aged patients with atypical symptomatology].

Present-day therapeutic possibilities, both medical and surgical, make it mandatory for the practitioner to identify elderly patients with ischemic heart disease which in these patients often presents with atypical symptoms. Twenty elderly patients with not clear-cut symptoms of coronary disorder were submitted to an exercise test on a walking belt. In 14 (70%) the test was positive and in 8 of these 14 cases previous dynamic electrocardiography had not yielded signs of ischemia. The authors consider correctly performed exercise testing the best means for identifying the often not diagnosed coronary impairment of elderly subjects.

Age Factors↗
PubMed1989

Hemodynamic and clinical effects of captopril in patients with severe congestive heart failure.

In a group of 10 patients (9 male, 1 female, aged 16 to 56, mean 43 years) with severe congestive heart failure (CHF), due to ischemic heart disease (8 cases) or dilatative cardiomyopathy (2 cases), the acute hemodynamic response to captopril (CPT) (90 min after 50 mg po) was evaluated. CPT was then given starting with 15 mg q 8 hr, gradually increased within 2 or 3 days to 50 or 75 mg q 8 hr. A hemodynamic re-evaluation was performed after 20 days, and, in 5 patients, after 1 year of CPT treatment. The clinical follow-up done every 3 months in the outpatient clinic. CPT acutely produced a decrease in mean pulmonary wedge pressure: 23.8 +/- 8.9 to 18.6 +/- 8.6 mmHg, p less than 0.01, and an increase in cardiac index: 2.43 +/- 0.73 to 2.91 +/- 0.85 l/min/m2, p less than 0.01; systemic and pulmonary resistances decreased significantly, with no significant changes in heart rate and in mean brachial artery pressure. This favourable hemodynamic response persisted after 20 days of CPT treatment. In the group of 5 patients, who underwent a third hemodynamic evaluation, no statistically significant differences were demonstrated in respect to the previous control values. All patients on chronic CPT treatment experienced a gradual clinical improvement, reaching a steady state after 2 to 3 weeks; the surviving patients remained stable in the improved functional class for at least 6 months. The mortality rate was 30% in the first year, increasing to 50% in the second and to 60% in the third year of treatment. After a mean follow-up 35.7 months (range 33 to 39) the 4 surviving patients remained in the same functional class as after the first year for therapy. In our CHF patients CPT improved the quality of life, with the best clinical and hemodynamic results the first few months of treatment; life expectancy probably was not affected.

Adolescent↗
PubMed1988

A polygraphic study of systolic time intervals and their correlations with heart rate and workload during supine ergometry in one hundred normal subjects.

The present study was designed to investigate systolic time intervals (STI) in 100 normal subjects undergoing continuous-maximal supine cycle ergometry and to search for possible linear correlations between STI (dependent variables) and heart rate, diastolic blood pressure, systolic blood pressure, age, sex, weight, and height (independent variables), by stepwise regression analysis. The only significant correlation discovered in the study was between the contractility index (isometric contraction time-ICT) and the total work produced by each participant. Exercise tolerance was limited primarily by shortening of the ICT interval, all subjects discontinuing the test when ICT reached 13.7 +/- 7 ms.

Adult↗
PubMed1986

Influence of the heart rate on mean circumferential shortening velocity: echocardiographic study of 183 normal subjects.

Echocardiography was used to explore the influence of independent variables (age, body surface area and heart rate) on the mean circumferential shortening velocity (MVCF) in 183 healthy subjects. Multiple stepwise regression analysis shows that heart rate is the only variable of the three just mentioned that influences MVCF. A regression equation is evolved and proposed as an index of MVCF correction for varying heart rates.

Adolescent↗
PubMed1985

Maximal anaerobic (lactic) capacity and power of the horse.

Blood lactate concentrations were determined in 16 horses (three Thoroughbreds, seven Standardbreds and six polo ponies) before and 5 mins after they galloped over distances of 200, 300 and 400 m at maximal speed. The highest net lactate concentration (delta Lamax) of 14 to 15 mmol/litre was attained by the polo ponies and the highest speed by the Thoroughbreds. The maximal rate of lactate production (delta Låmax) was about 35 mmol/litre X min for the polo ponies and 20 to 25 mmol/litre X min for the Standardbreds and the Thoroughbreds. Values for delta Lamax and delta Låmax were similar to those measured in human athletes after exhaustive work. delta Låmax increases with the speed (v) and can be described by the equation delta Lå = a (v-v1), where a is a proportionality constant representing the amount of lactate needed to cover a unit distance and v1 the theoretical speed at which delta Lå = 0 X v1 was highest for the Thoroughbreds and lowest for the polo ponies; this difference could be caused by the effect of training and/or to genetic differences among the different breeds of horses X v1 could be a useful index of the fitness of a horse following a training programme.

Anaerobiosis↗
PubMed1985

The relationship of maximal alactacid anaerobic power to somatotype in trained subjects.

The purpose of the present study was to investigate the relationship between somatotype components and maximal alactacid anaerobic power (MAAP) in trained subjects. The somatotype components (endomorphy: means = 2.66, S.D. = +/- 0.78; mesomorphy: means = 5.45, S.D. = +/- 1.12; ectomorphy: means = 2.46, S.D. = +/- 0.88) and total MAAP were measured in 40 male fencers (aged, means 21.79, S.D. = +/- 3.97) in order to determine the correlations. The results did not show any correlations between the parameters. It can be concluded that the MAAP of an individual does not depend on the somatotype; but it may also be assumed that MAAP show changes with the percentage of fibre type, enzymatic activity in these fibres involved by large muscle groups which are relatively related to musculo-skeletal development (second component of somatotype) and neuro-muscular properties of the subjects, all having a genetic basis.

Adolescent↗