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F Schultz Larsen

Publications and source records attributed to F Schultz Larsen.

11 recordsLinked to original sources
PubMed1996

The occurrence of atopic dermatitis in north Europe: an international questionnaire study.

BACKGROUND: Atopic dermatitis is a common multifactorial disease that seems to be increasing in frequency. OBJECTIVE: Our purpose was to determine the increased prevalence of atopic dermatitis in North Europe. METHODS: Approximately 3000 7-year-old children in Denmark, Germany, and Sweden were enrolled in a cross-sectional questionnaire study that was conducted in the autumn of 1992 with common protocols and standardized procedures. RESULTS: The response rate was 90%. The frequency of atopic dermatitis was calculated to be 15.6% (95% confidence interval 14.2% to 17%) with some regional differences. Girls more often had flexural eczema and outnumbered boys in a ratio of 1.3:1.0. Boys more often had a personal history of asthma, whereas girls more often had a family history of asthma. CONCLUSION: The increasing prevalence of atopic dermatitis has been confirmed. This simple questionnaire model works well, is cost effective, and is sufficiently sensitive and specific to conduct large-scale epidemiologic investigations in school children.

Asthma↗
PubMed1993

Atopic dermatitis: a genetic-epidemiologic study in a population-based twin sample.

BACKGROUND: Atopic dermatitis is a common multifactorial disease that seems to be increasing in frequency. OBJECTIVE: Our purpose was to evaluate and expand previous findings on the incidence of atopic dermatitis and its concordance rates in twins. METHODS: A mailed questionnaire study was conducted. It involved 812 twin pairs living in Fyn County, Denmark, as of Jan. 1, 1987 and born between 1965 and 1979. Zygosity was determined by the similarity method. RESULTS: The response rate was 92%. The cumulative incidence rate (up to 7 years) of atopic dermatitis increased significantly from 0.06 for the birth cohort 1965-1969 to 0.12 for the birth cohort 1975-1979. The pairwise concordance rate was 0.72 in monozygotic and 0.23 in dizygotic twin pairs. CONCLUSION: The frequency of atopic dermatitis is still increasing but not as rapidly as in the 1960s. The magnitude of the concordance rates indicates that genetic factors are decisive in the development of atopic dermatitis. It is suggested that widespread environmental factors are operating in genetically susceptible persons.

Adolescent↗
PubMed1992

Secular change in the occurrence of atopic dermatitis.

Atopic dermatitis is a common disease, and population-based studies indicate that the frequency of atopic dermatitis has increased substantially during recent decades. It has been generally accepted that disease onset occurs before 7 years of age in 80-90% of the cases, and consequently the epidemiology of atopic dermatitis has been studied mostly in children on admission of first grade school. Before 1960 about 2-3% of children suffered from atopic dermatitis. In the 1960s, some 4-8% was recorded in several studies, and for those born after 1970 most researchers found that 9-12% developed atopic dermatitis during childhood. The diagnostic criteria of Hanifin and Rajka are cumbersome for population studies not designed specifically for children. In order to compare epidemiologic data from varying times and locations, a framework for questionnaire studies in atopic dermatitis is proposed.

Child↗
PubMed1989

IgG subclass antibodies to dietary antigens in atopic dermatitis.

The role of IgG subclasses and IgG subclass antibodies in atopic disease is controversial. Serum IgG and IgG subclass (IgG1-4) antibodies to the two dietary antigens ovalbumin (OA) and beta-lactoglobulin (BLG) were measured with ELISA-methods in 16 patients with mild or moderate atopic dermatitis (AD) and healthy controls. The IgG antibodies were measured in 31 patients with previous AD and controls. The IgG subclass antibodies to OA and BLG showed predominance of IgG4 and IgG1 for both patients and controls. The levels of IgG and IgG subclass antibodies to OA did not differ between the groups, but the levels of IgG and IgG4 anti-BLG antibody were higher in patients with active AD than in controls. The antibody levels did not correlate with severity of disease or with a history of food allergy/intolerance. IgG4 antibodies to dietary antigens may be elevated in AD, but the diagnostic significance of IgG subclass antibody measurement is limited.

Animals↗
PubMed1987

Genetic investigations in atopic dermatitis.

In a population based study of 68 individuals with atopic dermatitis and 94 control individuals it was not possible to demonstrate any significant associations between the disease and gene frequencies of HLA-ABC, ABO, MN, Rhesus, Kell, Duffy, Hp, Gc, Gm, Km/Inv, PGM, AcP, GPT, EsD, GLO, AK, PGD, ADA, and GALT/Gt.

Blood Group Antigens↗
PubMed1985

Lymphocyte transformation tests and subpopulations of lymphocytes in a population-based material of atopic dermatitis in twins.

Lymphocyte function and lymphocyte subpopulations in the peripheral blood have been studied in a population-based material of 47 twins with atopic dermatitis (AD) (31 with a history of AD, 10 with mild AD, and 6 with moderate AD) and in 47 age- and sex-matched non-atopic control twins. Lymphocyte transformations to phytohaemagglutinin, concanavalin A (Con A), pokeweed mitogen, and purified protein derivative of tuberculin were investigated. Lymphocyte subpopulations were characterized by EAET rosettes and the monoclonal antibodies OKT3, OKT4, and OKT8. None of these in vitro tests showed any statistically significant differences between patients and controls. In the rather few individuals with moderate AD there was a statistically insignificant tendency to a decreased Con A stimulation in suboptimal concentration and a reduction of the OKT8+ cells. However, there were definitely no alterations in the immunological variables between patients with a history of AD and controls. Our results indicate that the investigated variables could be related to disease activity. We suggest that they represent epiphenomena rather than pathogenetic mechanisms of importance for the development of AD.

Adolescent↗
PubMed1983

Ipratropium treatment for rhinorrhoea in patients with perennial rhinitis. An open follow-up study of efficacy and safety.

The efficacy and safety of intranasal ipratropium therapy for rhinorrhoea were tested in an open follow-up study of 20 adult patients with perennial rhinitis. The reduction of nasal hypersecretion of 40-45% obtained with 80 micrograms four times daily in a placebo-controlled study, was maintained over the next 4 weeks although the mean daily dose was reduced to 180 micrograms. The spray treatment was well tolerated and rhinoscopy, measurements of the sense of smell and the secretory responsiveness of the nose before and 10-48 months after the start of the trial did not reveal any signs of serious local adverse effects. It is concluded that ipratropium nasal spray is effective in the treatment of rhinorrhoea and appears to be safe for long-term use.

Administration, Intranasal↗
PubMed1979

Intranasal ipratropium: a new treatment for perennial rhinitis.

Eighty micrograms of the topically active parasympatholytic ipratropium were applied intranasally 4 times a day to 20 adult patients with perennial rhinitis and severe watery rhinorrhoea in a double-blind placebo controlled cross-over trial. There was a significant reduction in nasal hypersecretion during ipratropium treatment. Fourteen patients preferred the ipratropium period, 3 the placebo period and 3 had no preference. There were no adverse systemic or local effects. Ipratropium was effective also in patients resistant to glucocorticoids, sodium cromoglycate and antihistaminics. As the drug works immediately it can also be used before exposure to known provocating factors. It is concluded that continuous use of this new medication is of value in the management of severe rhinorrhoea in patients with perennial rhinitis, and that the occasional use is helpful in subjects with infrequent attacks of nasal hypersecretion.

Administration, Intranasal↗
PubMedDate not supplied

Genetic influence on the serum levels of naturally occurring human IgG antibodies to dietary antigens. Quantitative assessment from a twin study.

Serum IgG antibodies to ovalbumin (OA) and beta-lactoglobulin (BLG) were quantified by ELISA techniques in 22 monozygotic (MZ) and 24 dizygotic (DZ) healthy twin pairs. Antibody levels were comparable in the MZ and DZ groups both for anti-OA and anti-BLG antibodies. The genetic variance (GWT) was 0.167 for log IgG anti-OA antibodies, and 0.173 for log IgG anti-BLG antibodies, with heritability estimates of 0.44 and 0.37, respectively. No indication was observed of genotype-environmental interaction or differential environmental covariance for the log antibody levels in the MZ and DZ twins. The anti-OA and anti-BLG antibody levels in the same individual correlated only to a low degree. The levels of naturally occurring serum IgG antibodies are significantly influenced by genetic factors.

Adolescent↗