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F Sedef Tunaoğlu

Publications and source records attributed to F Sedef Tunaoğlu.

6 recordsLinked to original sources
PubMed2005

Distribution of syncopal episodes in children and adolescents with neurally mediated cardiac syncope through the day.

AIMS: To assess the relation between the timing of syncopal attacks and tilt test positivity. METHOD AND RESULTS: Prospective comparisons of distribution of syncopal attacks in 49 consecutive neurally mediated cardiac syncope (NMCS) patients (19 boys, 30 girls, mean age 13.7+/-0.68) were evaluated. Head-up tilt test (HUT) was positive in 28 patients and negative in 21. A questionnaire was given to every patient about the time and number of the syncopal attacks, presyncopal symptoms or signs before HUT. Although syncopal attacks were found to be concentrated in the morning especially between 10 AM and 12 noon in HUT positive patients (P < 0.001), there was a concentration in the late afternoon and evening period of the day especially between 2 PM and 6 PM in HUT negative patients (P < 0.001). CONCLUSION: It was assumed that diurnal variation in autonomic function may be the factor in the timing of syncopal events during morning hours in the HUT positive NMCS children and adolescents.

Adolescent↗
PubMed2005

Late cardiac evaluation of children with solid tumors after anthracycline chemotherapy.

BACKGROUND: The therapeutic potential of anthracycline antibiotics is limited by their cardiotoxicity. Electrocardiography, exercise testing, and two-dimensional echocardiography are non-invasive techniques used in the follow-up of children for cardiotoxicity. Plasma B-type natriuretic peptide (BNP) levels are thought to be useful markers in the early detection of AC induced cardiomyopathy. PROCEDURE: We evaluated cardiac status of 34 patients with solid tumors treated with anthracycline antibiotics. All of the patients were asymptomatic and had no evidence of residual malignancy. They were evaluated by electrocardiography, exercise testing, echocardiography, and plasma BNP levels measured before and after the exercise testing. RESULTS: Electrocardiography revealed only minor abnormalities of little clinical significance. All of the patients completed the exercise testing without complication, and the duration of the exercise for each patient was between normal limits. Cardiac output (CO) and wall stress (WS) were significantly increased in patients, than in controls in echocardiographic evaluation of systolic functions (P < 0.001). Diastolic filling patterns showed various abnormalities; M-E, M-A, T-E, T-A, AT, and IVRT were significantly higher than those of controls. Mean plasma BNP levels of the patients (10.56 +/- 10.22 pg/ml) were significantly higher than BNP levels of the healthy controls (4.09 +/- 2.26 pg/ml) (P < 0.016), before exercise testing. The mean plasma BNP levels of the patients (15.70 +/- 14.06 pg/ml) were higher than resting state after exercise testing, but it was not statistically significant (P > 0.05). CONCLUSION: Our findings demonstrated that echocardiographic and biochemical abnormalities could be found even at low cumulative doses of AC antibiotics. The use of serial echocardiographic studies and plasma BNP determinations to identify high-risk patients for cardiotoxicity needs to be verified by additional studies.

Adolescent↗
PubMed2004

Effective regurgitant orifice area of rheumatic mitral insufficiency: response to angiotensin converting enzyme inhibitor treatment.

OBJECTIVE: This study was designed for quantification of mitral regurgitation by echocardiographic measurements such as regurgitant volume (RV), regurgitant fraction (RF) and effective regurgitant orifice area (EROA), and to assess the effect of angiotensin converting enzyme inhibitor (ACEI) therapy on these measurements. METHODS: Patients with rheumatic mitral insufficiency were divided into two groups: Study group (SG)-10 females, 2 males, aged 10-18 years, body surface area 1.49+/-0.05 m2, receiving digoxin therapy for at least one year and Control group (CG)-8 females, 4 males, aged 8-17 years, body surface area 1.38+/-0.07 m2, with no treatment. Patients in the two groups had no symptoms of cardiac failure. Angiotensin converting enzyme inhibitor therapy was given to SG patients on admission. Echocardiographic examinations were applied on admission and at the 20th day of therapy with ACEI and digoxin. RESULTS: Study group's left ventricular end-diastolic volume (108.03+/-41.21 ml/m2), mitral stroke volume (510.37+/-321.58 ml/m2) and regurgitant volume (423.48+/-305.00 ml/m2) were significantly higher (p<0.05) on admission than in the CG (81.98+/-21.53 ml/m2, 315.34+/-207.38 ml/m2 and 245.77+/-179.84 ml/m2, respectively). Aortic stroke volume at the 20th day of therapy was significantly higher in SG than in the CG. Therapy with ACEI decreased significantly SG's left ventricular end-diastolic volume. CONCLUSION: Angiotensin converting enzyme inhibitors should be started at an early stage of mitral regurgitation. The effective regurgitant orifice area is a feasible and easy method for the outpatient follow-up of mitral regurgitation.

Administration, Oral↗
PubMedDate not supplied

Noncompaction with arcus aorta anomalies.

An 18-month-old girl with tetralogy of Fallot (TOF), mental retardation and multiple infarcts on brain computerized tomography (CT) is presented. Her sineangiocardiograms showed a thrombus (moving from the left ventricle to ascending and abdominal aorta), TOF, right arcus aorta with anomalous origin of left subclavian artery from the descending aorta, honeycombed appearance of the apex and half of the posterior wall of left ventricle and the apex of right ventricle. Her echocardiography (ECHO) examinations revealed depressed left ventricular systolic function and thrombus in the left ventricle apex, with noncompaction of the left ventricle apex and the middle portion of posterior wall, and in the right ventricular apex.

Brain↗