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Biomedical subjects

F Senegas-Balas

Publications and source records attributed to F Senegas-Balas.

23 records · Page 2Linked to original sources
PubMed1980

Effects of pancreatic duct ligation on the hamster intestinal mucosa. Histological findings.

After pancreatic duct ligation good correlations were observed between degenerative signs of the exocrine pancreas and ultrastructural changes of intestinal epithelial cells: hypertrophy of Paneth and goblet cells; hyperplasia of Paneth cells, mucous cells and 'intermediate granular cells' after the 10th day. On the 7th day, the absorbing area of the intestine (villi area and microvilli area) decrease significantly. These cytological changes partially disappear after the 15th day concomitant to a partial regeneration of the exocrine pancreas. These findings suggest correlations between the epithelial cells of the small intestine and exocrine pancreatic secretion. Different possibilities (direct action of the pancreatic juice or indirect mechanisms) are discussed and proposed to explain the morphological variations of the intestinal mucosa after pancreatic duct ligation.

Animals↗
PubMed1979

A cyto-physiological study of the G-cell secretory cycle in the antrum mucosa of the hamster and of the rat.

The secretory cycle of the antral G cell in the golden hamster and in the Wistar rat has been investigated, using classical techniques of optical and electron microscopy associated with special methods (such as goniometry, densitometry, immunohistology, morphometry) and with radioimmunoassay for gastrin. This paper confirms the secretory cycle of the G cell after refeeding. It clarifies the nature of granule polymorphism and suggests a particular mechanism of emiocytosis with sequential granule fusion. Furthermore, our investigations show some dissociations between the G cell, the parietal cycle, and the seric immunoreactive gastrin in the late phase of the secretory cycle (2 to 6 h after refeeding).

Animals↗
PubMed1979

Comparative effects of CCK-PZ on certain intestinal hydrolases in the mucosa and in the luminal content of the hamster jejuno-ileum.

After isolation of the hamster small intestine, the effects of a continuous infusion of cholecystokinin-pancreozymin (CCK-PZ) are studied. Several enzymic activities are measured in the intestinal lumen and compared with the level found in the intestinal homogenate. During CCK-PZ infusion we observed a direct stimulation of Paneth cells associated with an increase of lysozyme activity. Furthermore this work confirms the stimulating effect of CCK-PZ on alkaline phosphatase and amino-peptidase. Maltase and sucrase levels were unaffected. The liberation of the hydrolase of the brush border in the intestinal lumen is negligible and cannot be considered as a true secretion. Only granule content of Paneth cells is actually secreted. However, biochemical data, corroborated by morphological results, suggest that Paneth cell secretion could in part be absorbed on the outer surface of the brush border.

Alkaline Phosphatase↗
PubMedDate not supplied

Diet supplemented with yoghurt or milk fermented by Lactobacillus casei DN-114 001 stimulates growth and brush-border enzyme activities in mouse small intestine.

The nutritional benefits of lactic acid bacteria in fermented dairy products have been well documented, especially in terms of weight gain and feed efficiency, but not in terms of small intestine adaptation. The effects of a diet supplemented (30% wt/wt) with milk fermented either by Lactobacillus casei DN-114 001 or yoghurt for 3 or 15 days were investigated in the small intestine of mice by morphometry, kinetic analysis and determination of brush-border enzyme activities. Results were compared with those obtained with standard or milk isocaloric diets. Cell proliferation and villous area were significantly increased in the proximal intestine of mice fed the fermented-milk-supplemented diets for 3 days and were associated with hypertrophy and hyperplasia of Paneth and goblet cells. Lactase-specific activity was increased by fermented-milk diets at days 3 and 15, whereas there was no variation in maltase-specific activity. Alkaline phosphatase-specific activity was increased after 3 days of the three tested diets in the whole intestine, and after 15 days in the proximal intestine. Aminopeptidase activity was increased in the distal part of the intestine after 3 days of the 3 diets. Our findings suggest that diets supplemented with fermented milks have a positive effect on the trophicity of the mucosa in the small intestine of mice.

Alkaline Phosphatase↗