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F Signorelli

Publications and source records attributed to F Signorelli.

29 records · Page 2Linked to original sources
PubMed1995

'De novo' aneurysm formation: report of two cases.

We report 2 cases of 'de novo' aneurysm formation in a vessel which appeared to be normal at a previous angiography. The first patient developed an anterior communicating artery aneurysm nine years after occlusion of the right internal carotid artery by Gianturco coils for the treatment of a giant intracavernous carotid aneurysm. In the second case a 'de novo' aneurysm of the internal angle A1-A2 segment of the left anterior cerebral artery developed 6 years after successful clipping of another aneurysm of the same location. De novo formation of an aneurysm in a vessel which was found to be normal in a previous angiographic study, may occur as result of hemodynamic changes, such as after internal carotid occlusion or in presence of an arteriovenous malformation or variations of the circle of Willis. However, definite hemodynamic changes may also be absent. We conclude that patients operated on for aneurysm clipping must be periodically explored by magnetic resonance angiography to evaluate the possibility of de novo appearance of another aneurysm.

Adult↗
PubMed1994

Post-radiation cerebral lesions in adults.

For many years, the human brain was considered relatively resistant to therapeutic doses of radiation. With the increasing length of survival of patients irradiated for brain tumors, there have been reported long-term effects of radiation therapy due to inappropriate dosage, period of delivery, fractionation or field. Thus, randomized studies are needed both to optimize the radiation therapy technique than to integrate new therapeutic modalities into the management of patients with primary brain tumors.

Brain↗
PubMed1994

Leptomeningeal carcinomatosis: review of the literature.

Metastases from solid tumors that seed the leptomeninges (meningeal carcinomatosis) are an important neurologic complication of systemic cancer. Recently many authors have reported that its incidence is increasing; particularly it has been demonstrated for breast cancer and small cell bronchogenic carcinoma. A cytologic examination of cerebrospinal fluid (CSF) establishes the diagnosis. Gadolinium-enhanced MRI has demonstrated superiority over other imaging with the clinical context and CSF analysis may lead to a rapid diagnosis and treatment of leptomeningeal carcinomatosis. Despite all measures, prognosis remains poor because of the presence of multiple metastases elsewhere.

Carcinoma↗
PubMed1994

Correlation between sex hormone receptors and peritumoral edema in intracranial meningiomas.

Fifty patients with intracranial meningiomas, verified histologically, are retrospectively analyzed to correlate the peritumoral brain edema with the positivity of estrogen receptors and progesterone receptors. The extent of edema was quantified on CT scan and/or MR. Monoclonal antibodies were used to test the estrogen receptors and the dextran-coated charcoal method was used to test the progesterone receptors. Significant levels of both receptors were found in 41 (82%) specimens. 80% of the cases with positive receptors had brain edema, in contrast to only 2 among 9 cases with negative receptors. Thus, the presence of brain edema has resulted to be correlated to the positivity of sex hormone receptors, although we did not find significant correlation between the amount of receptors and the amount of edema. The suggested mechanisms responsible for the brain edema surrounding intracranial meningiomas are discussed. We can suggest that progesterone may induce the secretion of some substances from meningioma cells, such as prostaglandins and biogenic amines, which may result in vagogenic edema.

Adult↗
PubMed1991

[Comparison of mechanical and manual anastomoses in emergency gastric resection].

Hundred and twenty-one patients underwent emergency subtotal gastrectomy for complications related to peptic ulcer (86) and malignant diseases (35). According to the type of anastomosis performed (manual or mechanical) patients were divided into two groups: 81 with hand-sutured anastomoses (double layer) and 40 with stapled anastomoses. The latter were more commonly used in the Roux-en-Y reconstruction and Billroth 1 gastrectomy. Median operating time (192' versus 190'), hospital stay (15.2 versus 13.5 days), postoperative complications (38% versus 32.5%) and anastomotic or duodenal stump leakage (7.4% versus 5%) showed no significant difference between groups. Therefore, in emergency subtotal gastrectomy mechanical anastomoses allow to obtain results comparable to the more used manual ones.

Adult↗
PubMedDate not supplied

Is reoperation for recurrence of glioblastoma justified?

The purpose of the present study was to determine the effect of surgery on the time length and quality of survival in patients with recurrent glioblastoma multiforme. Two groups were compared; the first included 18 patients who underwent surgery at the time of tumour recurrence. The second group included 36 patients who did not undergo surgery at the time of tumour recurrence. Both groups were matched according to the following criteria: gender, age, Karnofsky Performance Scale (KPS) score, at the time of initial surgery and of tumour recurrence, extent of initial surgery, interval between initial surgery and tumour reccurence. Both groups received conventional treatment after initial surgery. There are no statistically significant differences between the two groups as regards to the previously mentioned criteria. After tumour recurrence, the median survival time was 5 months in the group of patients undergoing a second resection and 2 months in the group of patients not undergoing repeat surgery. The difference was statistically significant on univariate analysis. Moreover, the median length of time spent in an acceptable condition (KPS >/=60) from the time of tumour recurrence was found to be significantly longer in patient who underwent a second resection (4 months) compared with patients who did not undergo repeat surgery (1 month). Even in a relatively favorable subgroup of reoperated patients, the survival benefit although significant was only 3 months. It was impossible to completely match the two groups of patients suggesting that the difference might have been even less. Although symptomatic improvement is modestly achieved by repeat surgery, its transient nature necessitates clear discussion with patient and family on an individual basis.

Adult↗
PubMedDate not supplied

Cerebral hemorrhagic complication in polyarteritis nodosa. Case report and review of the literature.

Polyarteritis nodosa (PN) is frequently cause of both central and peripheral neurological disorders. However, involvement of the central nervous system is rare at the beginning of the disease. In this paper we report a case of a 38-year-old woman hospitalized in our Neurosurgical Service because of left hemiparesis in presence of cutaneous arteritis (PN). At computed tomography (CT) an intracerebral hemorrhage was found. No radiographic evidences of vasculitis of the visible arterial branches, at angiography, were seen. Cerebral arteritis should be suspected as a cause for intracranial hemorrhage in patients without hypertension or other risk factors.

Adult↗